Necrotizing fasciitis in childhood

Murphy, James J.; Granger, Robert; Blair, Geoffrey K.; Miller, Grant G.; Fraser, Graham C.; Magee, J.Fergall

doi:10.1016/0022-3468(95)90004-7

Cited by 57 publications

(39 citation statements)

References 10 publications

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“…Earlier studies have suggested that NF was slightly more common in patients aged above 50 years (10,(20)(21)(22)(23) and that malignancy was a contributing factor for NF due to impaired leucocyte function in such patients. (18,24,25) Contrary to these studies, we found that malignancy and age groups were negatively correlated with the occurrence of NF during the three-year follow-up period. These findings may have been influenced by the fact that patient death was indicated as 'censored' in our study.…”

Section: Discussioncontrasting

confidence: 99%

Liver cirrhosis as a real risk factor for necrotising fasciitis: a three-year population-based follow-up study

Hung¹,

Tsai²,

Tseng³

et al. 2014

smedj

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RESULTSDuring the three-year follow-up period, there were 299 (0.7%) cirrhotic patients with NF and 160 (0.4%) non-cirrhotic patients with NF. Cox regression analysis showed that liver cirrhosis was a risk factor for the occurrence of NF during the study period (hazard ratio 1.982; p < 0.001). Among cirrhotic patients, those with complicated liver cirrhosis had a higher risk for the occurrence of NF than patients with non-complicated liver cirrhosis (hazard ratio 1.320; p = 0.028).CONCLUSION Cirrhotic patients had a higher risk for the occurrence of NF than non-cirrhotic patients, and the risk for NF was especially high among patients with complicated liver cirrhosis.

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Section: Discussioncontrasting

confidence: 99%

Liver cirrhosis as a real risk factor for necrotising fasciitis: a three-year population-based follow-up study

Hung¹,

Tsai²,

Tseng³

et al. 2014

smedj

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“…Life-threatening necrotizing skin and soft-tissue infections can develop in neutropenic patients (29,40). Animal models of neutropenia induced by cyclophosphamide have also demonstrated an increased incidence of bacterial infection (13,59).…”

Section: Discussionmentioning

confidence: 99%

Keratinocyte Production of Cathelicidin Provides Direct Activity against Bacterial Skin Pathogens

Braff¹,

et al. 2005

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Immune defense at an interface with the external environment reflects the functions of physical and chemical barriers provided by epithelial and immune cells. Resident epithelial cells, such as keratinocytes, produce numerous peptides with direct antimicrobial activity but also provide a physical barrier against invading pathogens and signal the recruitment of circulating immune cells, such as neutrophils. Antimicrobial peptides such as cathelicidin are produced constitutively by neutrophils and are inducible in keratinocytes in response to infection. The multiplicity of antimicrobial peptides and their cellular sources has resulted in an incomplete understanding of the role of cathelicidin production by epithelial cells in cutaneous immune defense. Therefore, this study sought to evaluate keratinocyte antimicrobial activity and the potential contribution of keratinocyte cathelicidin to host protection against two leading human skin pathogens. Wild-type mice and those with a targeted deletion of the cathelicidin gene, Cnlp, were rendered neutropenic prior to cutaneous infection. Interestingly, Cnlp-deficient mice remained more susceptible to group A streptococcus infection than mice with Cnlp intact, suggesting the involvement of epithelial cell-derived cathelicidin in host immune defense. Keratinocytes were then isolated in culture and found to inhibit the growth of Staphylococcus aureus, an effect that was partially dependent on their ability to synthesize and activate cathelicidin. Further, lentivirusmediated delivery of activated human cathelicidin enhanced keratinocyte antimicrobial activity. Combined, these data illustrate the potential contribution of keratinocyte cathelicidin to the innate immune defense of skin against bacterial pathogens and highlight the need to consider epithelial antimicrobial function in the diagnosis and therapy of skin infection.

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“…Children with immune deficiency states, neutropenic states following chemotherapy are susceptible to NF as well. 10 In conclusion, NF following a single injection may be initially misinterpreted as localized cellulitis, and initial suspicion may prevent further serious and life threatening complications.…”

Section: Discussionmentioning

confidence: 97%

“…It has been reported following minor trauma, insect bites, local and systemic infections and surgical procedures. 3,[9][10][11][12][13][14] It is also common after varicella infections. 12 The disease can be presented with cellulitis or small abscesses and primary diagnosis of NF can be misinterpreted.…”

Section: Discussionmentioning

confidence: 99%

A Very Uncommon Complication Following Vaccination: Necrotizing Fasciitis and Myonecrosis: Case Report

Şenaran¹,

Karalezli²,

Öğün³

2010

Turkiye Klinikleri J Med Sci

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Necrotizing fasciitis in childhood

Cited by 57 publications

References 10 publications

Liver cirrhosis as a real risk factor for necrotising fasciitis: a three-year population-based follow-up study

Liver cirrhosis as a real risk factor for necrotising fasciitis: a three-year population-based follow-up study

Keratinocyte Production of Cathelicidin Provides Direct Activity against Bacterial Skin Pathogens

A Very Uncommon Complication Following Vaccination: Necrotizing Fasciitis and Myonecrosis: Case Report

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