Necrobiosis Lipoidica with Sarcoid Reaction

Mehregan, Amir H.

doi:10.1001/archderm.1961.01580070149017

Cited by 31 publications

(15 citation statements)

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“…In up to 85% of the cases, the skin lesions are character istically found on the lateral and anterior surfaces of the lower legs ¡7, 8], even though other locations have been reported such as: upper limbs [ 1,9]; face and scalp [9][10][11][12], abdomen [13] or disseminated [14], The most reported atypical locations arc usually in nondiabetic patients, as in our patient [15]. Lecroq ct al.…”

Section: Case Reportmentioning

confidence: 83%

Chronic Balanitis with Palisading Granuloma: An Atypical Genital Localization of Necrobiosis lipoidica Responsive to Pentoxifylline

España

Sánchez-Yus²,

Serna

et al. 1994

Dermatology

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Section: Case Reportmentioning

confidence: 83%

Chronic Balanitis with Palisading Granuloma: An Atypical Genital Localization of Necrobiosis lipoidica Responsive to Pentoxifylline

España

Sánchez-Yus²,

Serna

et al. 1994

Dermatology

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“…This is an uncommon histological pattern. [12] The clue to diagnosis was the associated necrobiosis which is absent in sarcoidosis.…”

Section: Discussionmentioning

confidence: 99%

Necrobiosis lipoidica: A clinicopathological study in the Indian scenario

Thomas

Khopkar

2013

Indian Dermatol Online J

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Context:Necrobiosis lipoidica (NL) is a chronic granulomatous dermatitis that is commonly associated with diabetes mellitus. Most of the current knowledge about this entity is from western literature.Aims:This study evaluates the clinicohistological features of NL in an Indian scenario.Materials and Methods:We retrospectively reviewed clinical features, associated comorbidities, and biopsies of all patients with NL over a period of one year.Results:Five cases of NL were seen during the duration of the study. The preliminary clinical diagnosis ranged from sarcoidosis to tinea incognito. The commonest clinical presentation in the Indian scenario was of asymptomatic erythematous to skin-colored plaques and nodules on the shins with or without central atrophy. The most common site of involvement was the shin (3 of 5 patients). NL was associated with Diabetes mellitus in only two cases, both of whom were male patients. On histology, various patterns of inflammation were seen including the palisading, interstitial, and mixed granulomatous infiltrates. One patient had sarcoidal granulomas in association with an interstitial pattern. Features seen consistently in all cases include perivascular lymphoplasmacytic infiltrates, interstitial lymphocytic infiltrates, and fibroplasia. Interstitial mucin deposition was not observed in any of the biopsies.Conclusion:The diagnosis of NL was missed in most cases due to the rarity of the disease, absence of concomitant diabetes, and atypical presentations. Histology was a useful tool in clinching the diagnosis.

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“…NL can also be of the tuberculoid type, in which case granulomatous lesions may develop. In contrast, sarcoidosis is defined by well-formed epithelioid cell granulomas; however, necrobiotic changes can occur within the lesions in some patients with sarcoidosis10. In such cases, making a distinction between NL and sarcoidosis becomes a challenge.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Sarcoidosis Clinically Mimicking Necrobiosis Lipoidica in a Patient with Systemic Sarcoidosis

et al. 2012

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A 70-year-old woman with an 8-year history of systemic sarcoidosis developed round, red-brown eruptions, with central atrophic lesions on her lower legs. The features of the biopsy specimen resembled those of necrobiosis lipoidica (NL), but although necrobiosis was present there were well-formed non-necrotizing granulomas in the dermis. The histological diagnosis was cutaneous sarcoidosis. Systemic sarcoidosis presenting with NL has rarely been reported. The histological features of cutaneous sarcoidosis sometimes mimic those of other granulomatous diseases, including NL and granuloma annulare, which are difficult to distinguish. We discuss the novel association between sarcoidosis and other granulomatous diseases.

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Necrobiosis Lipoidica with Sarcoid Reaction

Cited by 31 publications

References 1 publication

Chronic Balanitis with Palisading Granuloma: An Atypical Genital Localization of Necrobiosis lipoidica Responsive to Pentoxifylline

Chronic Balanitis with Palisading Granuloma: An Atypical Genital Localization of Necrobiosis lipoidica Responsive to Pentoxifylline

Necrobiosis lipoidica: A clinicopathological study in the Indian scenario

Cutaneous Sarcoidosis Clinically Mimicking Necrobiosis Lipoidica in a Patient with Systemic Sarcoidosis

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