1942
DOI: 10.1001/archderm.1942.01500070044004
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Necrobiosis Lipoidica and Granuloma Annulare

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Cited by 29 publications
(8 citation statements)
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“…Epidemiologically, GA and NL share several char acteristics. The female-to-male ratios are 2.5:1 and 3.5:1 in GA and NL, respectively [5,9]. Two thirds of patients with GA will present within the first three decades, com pared with less than one half of patients with NL present ing within the same period [18,19].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Epidemiologically, GA and NL share several char acteristics. The female-to-male ratios are 2.5:1 and 3.5:1 in GA and NL, respectively [5,9]. Two thirds of patients with GA will present within the first three decades, com pared with less than one half of patients with NL present ing within the same period [18,19].…”
Section: Discussionmentioning
confidence: 99%
“…Necrobiosis lipoidica (NL) was described by Oppenheimer [2] under the title dermatitis atrophicans lipoides diabetica 35 years later. In 1934 Ketron (dis cussing Traub [3]) suggested on histologic grounds that NL might be a variant of GA. Bernstein [4], Ellis [5] and Ellis and Kirby-Smith [6] expanded upon the histologic similarities of N L toG A , while questioning the separation of NL and GA into distinct entities. In 1949 Laymon and Fisher [7] recognized subtle microscopic differences between GA and NL, allowing them to be classified as separate disorders.…”
Section: Introductionmentioning
confidence: 99%
“…5 The epithelioid nodule pattern of granuloma annulare is not common. 20 However, all of the biopsies from their study having "small areas with a tuberculoid or sarcoid architecture" were diagnosed as necrobiosis lipoidica. 17 However, in addition to noncaseating granulomas of epitheloid histiocytes containing homogeneous cytoplasm without surrounding inflammation, the absence of asteroid or other giant cell inclusions and the presence of increased mucin between collagen bundles suggest the diagnosis of granuloma annulare.…”
Section: Discussionmentioning
confidence: 94%
“…4 Indeed, the pathologic features are nearly identical to those observed in lesions of cutaneous sarcoidosis. 20 Nearly a quarter century later, in a study of 14 patients with necrobiosis lipoidica, Gray et al 18 Ackerman 17 included a photomicrograph of "granuloma annulare with sarcoidal features" as an "unusual histologic variant of granuloma annulare (that) resembles sarcoidosis by formation of 'naked' epithelioid tubercules" in the first edition of seminal dermatopathology textbook published in 1978. 1,4 One group of investigators found areas of an infiltrative pattern around the epithelioid nodules 4 ; yet, this is not usually observed.…”
Section: Discussionmentioning
confidence: 99%
“…(Goldberg, 1943) to 30 per cent. (Ellis and Kirby Smith, 1942) of patients with this lesion are not diabetic, the distinction, both clinical and pathological, if it is a real one,. may be difficult.…”
Section: Discussionmentioning
confidence: 93%