Near IR Heptamethine Cyanine Dye–Mediated Cancer Imaging

Yang, Xinggang; Chen, Shi; Tong, Rong; Qian, Weiping; Zhau, Haiyen E.; Wang, Ruoxiang; Zhu, Guodong; Cheng, Jianjun; Yang, Vincent W.; Cheng, Tianmin; Henary, Maged; Strękowski, Lucjan; Chung, Leland W.K.

doi:10.1158/1078-0432.ccr-10-0059

Cited by 247 publications

(313 citation statements)

References 51 publications

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“…Shi and Chung et al identified a class of NIR fluorescence heptamethine cyanines (1-3) for tumor imaging. 60,61 These small molecular dyes could be taken up and accumulated in tumor cells without requiring chemical conjugation with tumorspecific targeting ligands. The recognition mechanism was mediated by hypoxia-induced HIF-1a and specific organic anion transporting polypeptides (OATPs).…”

Section: Nir Imaging Fluorophoresmentioning

confidence: 99%

Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

et al. 2017

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Surgical resection of solid tumors is currently the gold standard and preferred therapeutic strategy for cancer. Chemotherapy drugs also make a significant contribution by inhibiting the rapid growth of tumor cells and these two approaches are often combined to enhance treatment efficacy. However, surgery and chemotherapy inevitably lead to severe side effects and high systemic toxicity, which in turn results in poor prognosis. Precision medicine has promoted the development of treatment modalities that are developed to specifically target and kill tumor cells. Advances in in vivo medical imaging for visualizing tumor lesions can aid diagnosis, facilitate surgical resection, investigate therapeutic efficacy, and improve prognosis. In particular, the modality of fluorescence imaging has high specificity and sensitivity and has been utilized for medical imaging. Therefore, there are great opportunities for chemists and physicians to conceive, synthesize, and exploit new chemical probes that can image tumors and release chemotherapy drugs in vivo. This review focuses on small molecular ligand-targeted fluorescent imaging probes and fluorescent theranostics, including their design strategies and applications in clinical tumor treatment. The progress in chemical probes described here suggests that fluorescence imaging is a vital and rapidly developing field for interventional surgical imaging, as well as tumor diagnosis and therapy.

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Section: Nir Imaging Fluorophoresmentioning

confidence: 99%

Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

et al. 2017

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“…Currently, heptamethine indocyanine dyes such as IR-780 iodide, IR-783 (Figure 3), MHI-148, and porphyrin derivatives Pz 247, are identified with preferential accumulation in cancer tissues, displaying great advantages over the common fluorescent dyes, like ICG. 104 Although the mechanism accounting for the specific accumulation and retention of these dyes remains unclear, the implications of mitochondrial membrane potential, organic-anion transporting polypeptides (OATPs), and EPR effect in this process have been illustrated. These natively multifunctional NIRF dyes extend our understanding in tumor-targeted imaging.…”

Section: Native Nirf Dyes With Tumor-targeting Abilitymentioning

confidence: 99%

Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

Yi¹,

Wang²,

Qin³

et al. 2014

IJN

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209

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Near-infrared fluorescence (NIRF) imaging is an attractive modality for early cancer detection with high sensitivity and multi-detection capability. Due to convenient modification by conjugating with moieties of interests, NIRF probes are ideal candidates for cancer targeted imaging. Additionally, the combinatory application of NIRF imaging and other imaging modalities that can delineate anatomical structures extends fluorometric determination of biomedical information. Moreover, nanoparticles loaded with NIRF dyes and anticancer agents contribute to the synergistic management of cancer, which integrates the advantage of imaging and therapeutic functions to achieve the ultimate goal of simultaneous diagnosis and treatment. Appropriate probe design with targeting moieties can retain the original properties of NIRF and pharmacokinetics. In recent years, great efforts have been made to develop new NIRF probes with better photostability and strong fluorescence emission, leading to the discovery of numerous novel NIRF probes with fine photophysical properties. Some of these probes exhibit tumoricidal activities upon light radiation, which holds great promise in photothermal therapy, photodynamic therapy, and photoimmunotherapy. This review aims to provide a timely and concise update on emerging NIRF dyes and multifunctional agents. Their potential uses as agents for cancer specific imaging, lymph node mapping, and therapeutics are included. Recent advances of NIRF dyes in clinical use are also summarized.

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“…They show low autofluorescence, but when combined with biological molecules, they induce strong fluorescence after being chemically modified to improve the stability of the molecules. 19 Importantly, these dyes do not cause cytotoxicity or systemic toxicity in mice when administered in a dose range appropriate for imaging.…”

Section: Introductionmentioning

confidence: 99%

Review on near-infrared heptamethine cyanine dyes as theranostic agents for tumor imaging, targeting, and photodynamic therapy

2016

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Review on near-infrared heptamethine cyanine dyes as theranostic agents for tumor imaging, targeting, and photodynamic therapy," J. Biomed. Opt. 21(5), 050901 (2016), doi: 10.1117/1.JBO.21.5.050901. Abstract. A class of near-infrared fluorescence (NIRF) heptamethine cyanine dyes that are taken up and accumulated specifically in cancer cells without chemical conjugation have recently emerged as promising tools for tumor imaging and targeting. In addition to their fluorescence and nuclear imagingbased tumor-imaging properties, these dyes can be developed as drug carriers to safely deliver chemotherapy drugs to tumors. They can also be used as effective agents for photodynamic therapy with remarkable tumoricidal activity via photodependent cytotoxic activity. The preferential uptake of dyes into cancer but not normal cells is co-operatively mediated by the prevailing activation of a group of organic aniontransporting polypeptides on cancer cell membranes, as well as tumor hypoxia and increased mitochondrial membrane potential in cancer cells. Such mechanistic explorations have greatly advanced the current application and future development of NIRF dyes and their derivatives as anticancer theranostic agents. This review summarizes current knowledge and emerging advances in NIRF dyes, including molecular characterization, photophysical properties, multimodal development and uptake mechanisms, and their growing potential for preclinical and clinical use.

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Near IR Heptamethine Cyanine Dye–Mediated Cancer Imaging

Cited by 247 publications

References 51 publications

Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

Review on near-infrared heptamethine cyanine dyes as theranostic agents for tumor imaging, targeting, and photodynamic therapy

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