Near infrared (NIR) spectroscopy for in-line monitoring of polymer extrusion processes

Rohe, Thomas; Becker, Wolfgang; Kölle, Sabine; Eisenreich, N.; Eyerer, Peter

doi:10.1016/s0039-9140(99)00035-1

Cited by 69 publications

(40 citation statements)

References 3 publications

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“…NIR spectroscopy has been applied in-line and in the transmission mode during single screw hot-melt extrusion to monitor the HDPE/PP [16,17] and LDPE/PP [18] polymer melt composition in the extrusion die. Further, NIR spectroscopy has been used to monitor the ethylene vinylacetate copolymer composition in the extrusion die during single screw extrusion [19][20][21] , and for the quantification of the copolymer composition in a polypropylene and ethylene vinyl acetate blend [22] during twin screw extrusion.…”

Section: Introductionmentioning

confidence: 99%

In-line NIR spectroscopy for the understanding of polymer–drug interaction during pharmaceutical hot-melt extrusion

Saerens

Dierickx

Quinten

et al. 2012

European Journal of Pharmaceutics and Biopharmaceutics

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The aim was to evaluate near-infrared spectroscopy for the in-line determination of the drug concentration, the polymer-drug solid-state behaviour and molecular interactions during hot-melt extrusion.Kollidon ® SR was extruded with varying metoprolol tartrate (MPT) concentrations (20, 30, and 40%) and monitored using NIR spectroscopy. A PLS model allowed drug concentration determination. The correlation between predicted and real MPT concentrations was good (R²=0.97). The predictive performance of the model was evaluated by the root mean square error of prediction, which was 1.54%. Kollidon®SR with 40% MPT was extruded at 105°C and 135°C to evaluate NIR spectroscopy for in-line polymer-drug solid state characterization.NIR spectra indicated the presence of amorphous MPT and hydrogen bonds between drug and polymer in the extrudates. More amorphous MPT and interactions could be found in the extrudates produced at 135°C than at 105°C. Raman spectroscopy, DSC and ATR FT-IR were used to confirm the NIR observations. Due to the instability of the formulation, only in-line Raman spectroscopy was an adequate confirmation tool. NIR spectroscopy is a potential PAT-tool for the in-line determination of API-concentration and for the polymer-drug solid state behaviour monitoring during pharmaceutical hot-melt extrusion.

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Section: Introductionmentioning

confidence: 99%

In-line NIR spectroscopy for the understanding of polymer–drug interaction during pharmaceutical hot-melt extrusion

Saerens

Dierickx

Quinten

et al. 2012

European Journal of Pharmaceutics and Biopharmaceutics

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“…Partial least squares (PLS) as a popular chemometrics algorithm has been used in NIR research and application for decades (Peussa et al 2000;Rohe et al 1999). Our process of building a PLS calibration model was carried out in the conventional leave-one-out cross-validation way.…”

Section: Chemometrics Modelmentioning

confidence: 99%

Studying the uptake of aniline vapor by active alumina through in-line monitoring a differential adsorption bed with near-infrared diffuse reflectance spectroscopy

et al. 2008

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Through non-invasive monitoring the uptake of aniline vapor by active alumina in a differential adsorption bed (DAB) with near-infrared diffuse reflectance spectroscopy (NIR-DRS), we have studied several features of the adsorption, including isotherm, kinetics and the chemical state of aniline molecules in aniline-alumina system. What is perhaps more important, since the information above is obtained synchronously, the proposed methodology could provide information about the type of adsorption (chemical or physical adsorption), the change of chemical state of aniline in the system during the adsorption process, whether the chemical adsorption and physical adsorption took place simultaneously, the rate of the chemical and physical adsorption, and so on.

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“…NIR spectroscopy has been successfully applied in the past to investigate material properties during in-line injection moulding and extrusion [3][4][5][6][7][8]. Relying on the sensitivity of the NIR system to detect material chemical and physical changes, NIR spectroscopy has also been used to assess the dispersion of fillers and nanoparticles in polymers during compounding [9,10].…”

Section: Introductionmentioning

confidence: 99%

Quantification of PLA contamination in PET during injection moulding by in-line NIR spectroscopy

2014

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In-line spectroscopy is a useful tool for monitoring processing conditions and polymer quality in the melt state in processes such as extrusion and injection moulding. This study extends the scope of this technique to the quantitative detection of poly(lactic acid) (PLA), which is a contaminant of concern in recycled poly(ethylene terephthalate) (PET). The near-infrared spectra of thermally treated PLA were studied for evidence of spectral changes which could be used as markers for PLA in PET, and these are discussed in detail. Several chemometric models for quantifying PLA in PET were developed and the influence of chemical or physical changes on the performance of the models is discussed. The selection of the final model was based on criteria aimed at eliminating interference due to spectral changes resulting from physical processes to give a robust model based specifically on the chemistry of the polymers studied. Finally, the models were tested against a new test mixture of known composition and the outputs are discussed.

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Near infrared (NIR) spectroscopy for in-line monitoring of polymer extrusion processes

Cited by 69 publications

References 3 publications

In-line NIR spectroscopy for the understanding of polymer–drug interaction during pharmaceutical hot-melt extrusion

In-line NIR spectroscopy for the understanding of polymer–drug interaction during pharmaceutical hot-melt extrusion

Studying the uptake of aniline vapor by active alumina through in-line monitoring a differential adsorption bed with near-infrared diffuse reflectance spectroscopy

Quantification of PLA contamination in PET during injection moulding by in-line NIR spectroscopy

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