Near-infrared laser light mediated cancer therapy by photothermal effect of Fe3O4 magnetic nanoparticles

Chu, Maoquan; Shao, Yuxiang; Peng, Jinliang; Dai, Xiangyun; Li, Haikuo; Wu, Qingsheng; Shi, Donglu

doi:10.1016/j.biomaterials.2013.01.086

Cited by 388 publications

(306 citation statements)

References 25 publications

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“…For this reason, a variety of nanoparticle systems are currently being explored for cancer therapeutics (Haley and Frenkel 2008), which include dendrimers (Zhao et al 2014), liposome (Allison 2007;Bovis et al 2012), micelles (Lee et al 2003), carbon nanotubes (Huang et al 2010), and polymeric nanoparticles (Kumari et al 2010;Li and Liu 2014). Several nanoparticles based on organic and inorganic chromophores, which show strong absorption in the near-infrared (NIR) tissuetransparency window, such as gold and carbon nanomaterials, have displayed encouraging photothermal therapeutic efficacy in preclinical animal experiments (Yuan et al 2012;Chu et al 2013). However, the major issue with these types of nanomaterials is their low biocompatibility, particularly their long-term toxicity, which limits their clinical application (Balasubramanian et al 2010;Zhang et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Polyaniline nanoparticles for near-infrared photothermal destruction of cancer cells

et al. 2015

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Polyaniline nanoparticles (PANI-Nps) have been used in several applications; however, there are few publications related to the use in the photothermal therapy. PANI-Nps have high optical absorbance in the near-infrared region and in this wavelength range, biological systems are relatively transparent. For this reason, these materials can be used to absorb energy and to generate heat that destroys cancer cells selectively. PANI-Nps with average size of ca. 200 nm and neutral zeta potential were synthesized and characterized by DLS, SEM, and zeta potential. The kinetics of incorporation of PANINps into LM2 cell line was monitored using UV-Vis spectrophotometry. The analysis of cell viability after PANI-Nps exposure shows that these nanoparticles are not cytotoxic even at high concentration and show no change in cell morphology and metabolic activity. Furthermore, we found that nanoparticle cell uptake reaches the maximum value c.a. 3 h after incubation. Cells were targeted by Pani-Nps and irradiated, resulting in significant elevation of intracellular ROS and heat production. One of the mechanisms of PANINps-mediated photothermal killing of cancer cells apparently involved oxidative stress resulting in apoptotic cell death.

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Section: Introductionmentioning

confidence: 99%

Polyaniline nanoparticles for near-infrared photothermal destruction of cancer cells

et al. 2015

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“…The photothermal effects of the magnetic Fe 3 O 4 NPs on cell and tumor tissue structures of esophageal cancer were further investigated ( Figure 7b). 73 The surface of Fe 3 O 4 NPs modified with carboxyterminated PEG-phospholipids enhanced their uptake by esophageal cancer cells and efficiently damaged the cellular organelles and inhibited esophageal tumor growth in mice. In addition to the surface reaction for improving the dispersion, different modifications of polymer 74 and inorganic 47 absorbers have been developed and have contributed to the strong absorbance in the NIR wavelengths.…”

Section: Fe 3 O 4 Nanostructuresmentioning

confidence: 99%

Revisiting the classification of NIR-absorbing/emitting nanomaterials for in vivo bioapplications

et al. 2016

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With the development of nonlinear optics and new imaging methods, near-infrared (NIR) light can excite contrast agents to probe biological specimens both functionally and structurally with a deeper imaging depth and a higher spatial resolution than linear optical approaches. There is considerable and growing interest in how biological specimens respond to NIR light. Moreover, the visible absorption band of most functional nanomaterials becomes NIR-excitable through multiphoton processes, thus allowing multifunctional imaging and combined therapy with noble metal and magnetic nanoparticles both in vitro and in vivo. A groundbreaking example is the use of different laser techniques to excite single-type NIR-absorbing/emitting nanomaterials to produce multiphoton emission by femtosecond lasers using either a remote control system for photodynamic therapy or photo-induced chemical bond dissociation. These techniques provided superior anatomical resolution and detection sensitivity for in vivo tumor-targeted imaging than those offered by conventional methods. Here we summarize the most recent progress in the development of smart NIR-absorbing/emitting nanomaterials for in vivo bioapplications.

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“…Superparamagnetic iron oxide nanoparticles (SPIONs), which possess unique properties including non-toxicity, magnetic properties, chemical stability, and biocompatibility, [9][10][11] have also been recently discovered to have photothermal effect and therefore could be used as an alternative PTT material. 9,[12][13][14][15] Chen et al 14 reported that the highly crystallized iron oxide nanoparticles administered through the tail vein for PTT as effective and biodegradable mediators.…”

Section: Introductionmentioning

confidence: 99%

“…9,[12][13][14][15] Chen et al 14 reported that the highly crystallized iron oxide nanoparticles administered through the tail vein for PTT as effective and biodegradable mediators. These injected nanoparticles are likely to be applied for PTT as a result of the enhanced permeability and retention (EPR) effect and is cleared from the body through urinary excretion without long-term toxicity.…”

Section: Introductionmentioning

confidence: 99%

Hyaluronan-modified superparamagnetic iron oxide nanoparticles for bimodal breast cancer imaging and photothermal therapy

Yang¹,

Fu²,

Fang³

et al. 2016

IJN

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Near-infrared laser light mediated cancer therapy by photothermal effect of Fe3O4 magnetic nanoparticles

Cited by 388 publications

References 25 publications

Polyaniline nanoparticles for near-infrared photothermal destruction of cancer cells

Polyaniline nanoparticles for near-infrared photothermal destruction of cancer cells

Revisiting the classification of NIR-absorbing/emitting nanomaterials for in vivo bioapplications

Hyaluronan-modified superparamagnetic iron oxide nanoparticles for bimodal breast cancer imaging and photothermal therapy

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