Near‐Infrared Fluorescence Imaging of miRNA Using a Transmembrane Polypeptide‐Based Genetic Reporter
Wen‐Jie Shu,
Zhe Ma,
Xiaojie Tian
et al.
Abstract:MicroRNAs (miRNAs) are small noncoding RNAs that play important regulatory roles in multiple biological processes. Many miRNAs exhibit unique expression patterns and are considered as theranostic biomarkers in a variety of human diseases. A reporter system that is capable of imaging miRNA in vivo is crucial for investigating miRNA biology. In the present study, an organic anion‐transporting polypeptide 1B3 (OATP1B3)‐based genetic switch system is designed and optimized to achieve near‐infrared fluorescent imag… Show more
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