Near infrared dye-conjugated oxidative stress amplifying polymer micelles for dual imaging and synergistic anticancer phototherapy

Yang, Wonseok; Noh, Joungyoun; Park, Hoyeon; Gwon, Sian; Singh, Berwin; Song, Chul-Gyu; Lee, Dongwon

doi:10.1016/j.biomaterials.2017.10.043

Cited by 61 publications

(44 citation statements)

References 49 publications

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“…Moreover, irradiation at a single wavelength removes any possible inhomogeneity in the therapeutic stimulus that could arise when using two wavelengths with different penetration depths into biological tissues. Therefore, some composite systems have been designed to deliver PTT/PDT under a single irradiation, including all‐organic nanocomposites, such as ICG‐loaded Prussian Blue NPs, perfluorooctyl bromide (PFOB)‐ICG coloaded micelles (where PFOB can enhance PDT efficiency by modulating tumor hypoxia), and ROS‐generating polymers loaded with dyes, as well as several hybrid organic–inorganic nanostructures. These typically rely on ICG to provide fluorescence contrast and PDT, while the inorganic part of the nanocomposite (Ag, CuS, graphene oxide) enhances the photothermal effect …”

Section: Nanomaterials For Fluorescence‐guided Combination Therapymentioning

confidence: 99%

Beyond Phototherapy: Recent Advances in Multifunctional Fluorescent Nanoparticles for Light‐Triggered Tumor Theranostics

Rosal

Jia

Jaque

2018

Adv Funct Materials

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Nanoparticles (NPs) have attracted great attention for cancer diagnosis and therapy thanks to their unique properties that enable specific tumor uptake, image-guided diagnosis, and tumor suppression triggered by one or more therapeutic modalities. Light-activated NPs have gained particular interest as minimally invasive theranostic agents for fluorescence-guided tumor diagnosis and highly selective phototherapy. The most recent advances in the field focus on shifting their spectral operation range to the second biological window (1000-1400 nm), while improving their efficacy, selectivity, and multifunctionality. In the past few years, multiple systems capable of light-triggered tumor diagnosis through fluorescence imaging (and in many cases, other imaging modalities) and subsequent tumor therapy have been synthesized and evaluated in small animal models. This review summarizes the different approaches for in vivo tumor theranostics, highlighting their advantages and limitations, and provides a critical analysis of the current state of the field.

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Section: Nanomaterials For Fluorescence‐guided Combination Therapymentioning

confidence: 99%

Beyond Phototherapy: Recent Advances in Multifunctional Fluorescent Nanoparticles for Light‐Triggered Tumor Theranostics

Rosal

Jia

Jaque

2018

Adv Funct Materials

View full text Add to dashboard Cite

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“…The combination of chemotherapy with hyperthermia and/or radiotherapy (CHRT) was demonstrated to have an enhanced anticancer effect and long-term survival benefits 7 . However, conventional chemotherapeutic drugs (e.g., doxorubicin) and imaging agents (e.g., indocyanine green) showed poor pharmacokinetic characteristics and tumor selectivity and thus caused significant side effects 8,9 . Therefore, it is necessary and significant to integrate diversified therapeutic and imaging agents into one formulation to realize the goal of (i) multimodal theranostic modality with tumor selectivity and (ii) synergistic imaging/therapeutic outcomes under lower drug dosages.…”

Section: Introductionmentioning

confidence: 99%

Bioinspired tumor-homing nanosystem for precise cancer therapy via reprogramming of tumor-associated macrophages

et al. 2018

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Rational design of smart nanosystems with high biological safety is a critical milestone for realizing precise imagingguided cancer theranostics. Herein, a bioinspired nanosystem was designed by camouflaging SPIO@DOX-ICG nanoparticles with cancer cell membrane (CCM) to realize precise cancer treatment through simultaneous chemotherapy, hyperthermia-therapy, and radiotherapy. CCM surface decoration preserves the cancer adhesion molecules and surface antigens in the nanosystem, endowing the nanosystem with tumor-homing ability and high biocompatibility. Guided by dual-modal imaging, the nanosystem specifically accumulated in the tumor region and achieved synergistic anticancer effects after combined treatment, without causing toxic side effects in major organs. Interestingly, the combined treatment also antagonized tumor hypoxia and reprogrammed the polarization of tumor associated macrophages to the antitumor M1 phenotype. Taken together, this study offers a smart strategy for designing a bioinspired tumor-homing nanosystem for precise cancer therapy.

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“…Near‐infrared (NIR) light‐mediated photothermal therapy (PTT) is a promising clinical cancer treatment that has attracted much attention in recent years . Additionally, gold nanorods (Au NRs) have been broadly applied to PTT, benefiting from its high light‐to‐heat conversion efficiency and good biocompatibility .…”

Section: Introductionmentioning

confidence: 99%

Heterostructures of MOFs and Nanorods for Multimodal Imaging

Zhang

Hao

et al. 2018

Adv Funct Materials

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Multifunctional heterostructures fabricated by assembling individual components are identified as a potential theranostic tool in biological fields, representing a strategy of great significance. Herein, heterodimers of the zeolitic imidazolate framework (ZIF)-8 and gold nanorods (Au NRs) are designed and synthesized for collaborative photothermal treatment and chemotherapy triggered by near-infrared (NIR) light. Furthermore, Ag 2 S, Ag 2 Se, upconversion fluorescent nanoparticles, and doxorubicin hydrochloride loaded into the ZIF-8 are released after intravenous injection. This release is attributed to the pH-responsive system, which simultaneously enabled computed tomography, photoacoustic, and NIR fluorescence imaging for tumors. Under NIR irradiation using an 808 nm laser, the tumor can be completely eliminated in vivo through multimodal imaging-guided chemophotothermal treatment. Overall, the present study makes several noteworthy contributions to the efficient diagnosis and treatment of cancer using the metal-organic frameworkassisted heterodimer as a versatile nanoplatform.

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Near infrared dye-conjugated oxidative stress amplifying polymer micelles for dual imaging and synergistic anticancer phototherapy

Cited by 61 publications

References 49 publications

Beyond Phototherapy: Recent Advances in Multifunctional Fluorescent Nanoparticles for Light‐Triggered Tumor Theranostics

Beyond Phototherapy: Recent Advances in Multifunctional Fluorescent Nanoparticles for Light‐Triggered Tumor Theranostics

Bioinspired tumor-homing nanosystem for precise cancer therapy via reprogramming of tumor-associated macrophages

Heterostructures of MOFs and Nanorods for Multimodal Imaging

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