volume 191, issue 4, P1536-1546 2013
DOI: 10.4049/jimmunol.1203571
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Natalia Ramos-Hernández, Hilda E. Ramon, Allison M. Beal, Ami Laroche, Erin A. Dekleva, Paula M. Oliver

Abstract: While the pathways that permit IL-2 production and the full activation of T cells upon antigen encounter are fairly well defined, the negative regulatory circuits that limit these pathways are poorly understood. Here we show that the E3 ubiquitin ligase adaptor Ndfip1 directs one such negative regulatory circuit. T cells lacking Ndfip1 produce IL-2, upregulate IL-2 receptor alpha (IL-2Rα), and proliferate, in the absence of CD28 co-stimulation. Furthermore, T cells in mice lacking both Ndfip1 and CD28 become …

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