Navigated single-capture 3D and cross-sectional wide-field OCT of the mid and peripheral retina and vitreoretinal interface

Abstract

Purpose: Assess the mid and peripheral neuroretina and vitreoretinal interface using a novel Navigated Single-Capture 3D and Cross-Sectional Wide-Field Swept-Source Optical Coherence Tomography (WF SS-OCT) technology with correlation to Multi-Wavelength Ultra-Widefield Imaging (MW UWFI) and Histopathology reference. Methods: Retrospective observational study. A total of 74 patients (148 eyes) were imaged using WF SS-OCT and Navigated Single-Capture twelve 23 mm cross-sectional radial scan pattern at 15° intervals. Image diagnosis included: congenital hypertrophy of the retinal pigment epithelium, choroidal nevus, ora serrata pearls, retinal tuft, lattice, snail track, cobblestone degeneration, retinal hole, retinal tear, degenerative retinoschisis, peripheral laser retinopexy, white without pressure, vitreous floaters, subclinical peripheral rhegmatogenous retinal detachment (RD), and tractional RD in proliferative diabetic retinopathy. WF SS-OCT images were correlated with MW UWFI and histopathological references where available. Results: WF SS-OCT successfully imaged structural features in all diagnoses with significant improvement in diagnostic capability and increased the diagnosis of specific features such as vitreoretinal attachment, full thickness hole or tear and subretinal fluid. Histopathological correlation was available for five (5) different peripheral retinal pathologies imaged by both WF SS-OCT and MW UWFI and good anatomical correlation was observed in all diagnosis. Conclusions: Navigated Single-Capture 3D and Cross-Sectional WF SS-OCT provides detailed anatomic information of the mid and peripheral neuroretina and vitreoretinal interface, allowing early recognition of vision-threatening features that may influence clinical management, particularly in an era of telemedicine or when there is limited or no access to Indirect Ophthalmoscopy with 360° Scleral Indentation.

Advantages of the Utilization of Wide-Field OCT and Wide-Field OCT Angiography in Clinical Practice

“…Vitreoretinal traction (VRT) was present in 10 of 27 eyes without a history of PPV. Similar imaging with WF-OCT scans of 23 mm in width was performed by Stanga et al [47]. Both Kurobe and Stanga emphasized the ease of the implementation and reliability of WF-OCT imaging for peripheral retinal disorders.…”

Advantages of the Utilization of Wide-Field OCT and Wide-Field OCT Angiography in Clinical Practice

“…Vitreoretinal traction (VRT) was present in 10 of 27 eyes without a history of PPV. Similar imaging with WF-OCT scans of 23 mm in width was performed by Stanga et al [47]. Both Kurobe and Stanga emphasized the ease of the implementation and reliability of WF-OCT imaging for peripheral retinal disorders.…”

The role of ultra-widefield imaging with navigated central and peripheral cross-sectional and three-dimensional swept source optical coherence tomography in ophthalmology: Clinical applications

“…[ 3 ] Peripheral and navigated SS-OCT has emerged as a pivotal tool in the detection of peripheral retinal lesions, providing clinicians a noninvasive, fast scanning, high-resolution imaging modality that can visualize the retina layers. [ 3 26 ]…”

Effects of blood pressure and arterial stiffness on retinal neurodegeneration: Cross-sectional and longitudinal evidence from UK Biobank and Chinese cohorts

“…20 OCT, a noninvasive and rapid retinal examination, can capture three-dimensional cross-sectional images of the retina and accurately measure the thicknesses of various parts of the retina. 21 Thinning of the RNFL and GCIPL leads to an increased risk of dementia as well as Alzheimer’s disease, and retinal neurodegeneration can be used as a preclinical biomarker for dementia.…”

Advantages of the Utilization of Wide-Field OCT and Wide-Field OCT Angiography in Clinical Practice

“…Vitreoretinal traction (VRT) was present in 10 of 27 eyes without a history of PPV. Similar imaging with WF-OCT scans of 23 mm in width was performed by Stanga et al [47]. Both Kurobe and Stanga emphasized the ease of the implementation and reliability of WF-OCT imaging for peripheral retinal disorders.…”

The role of ultra-widefield imaging with navigated central and peripheral cross-sectional and three-dimensional swept source optical coherence tomography in ophthalmology: Clinical applications

“…[ 3 ] Peripheral and navigated SS-OCT has emerged as a pivotal tool in the detection of peripheral retinal lesions, providing clinicians a noninvasive, fast scanning, high-resolution imaging modality that can visualize the retina layers. [ 3 26 ]…”

Effects of blood pressure and arterial stiffness on retinal neurodegeneration: Cross-sectional and longitudinal evidence from UK Biobank and Chinese cohorts

“…20 OCT, a noninvasive and rapid retinal examination, can capture three-dimensional cross-sectional images of the retina and accurately measure the thicknesses of various parts of the retina. 21 Thinning of the RNFL and GCIPL leads to an increased risk of dementia as well as Alzheimer’s disease, and retinal neurodegeneration can be used as a preclinical biomarker for dementia.…”

Advantages of the Utilization of Wide-Field OCT and Wide-Field OCT Angiography in Clinical Practice

“…Vitreoretinal traction (VRT) was present in 10 of 27 eyes without a history of PPV. Similar imaging with WF-OCT scans of 23 mm in width was performed by Stanga et al [47]. Both Kurobe and Stanga emphasized the ease of the implementation and reliability of WF-OCT imaging for peripheral retinal disorders.…”

The role of ultra-widefield imaging with navigated central and peripheral cross-sectional and three-dimensional swept source optical coherence tomography in ophthalmology: Clinical applications

“…[ 3 ] Peripheral and navigated SS-OCT has emerged as a pivotal tool in the detection of peripheral retinal lesions, providing clinicians a noninvasive, fast scanning, high-resolution imaging modality that can visualize the retina layers. [ 3 26 ]…”

Effects of blood pressure and arterial stiffness on retinal neurodegeneration: Cross-sectional and longitudinal evidence from UK Biobank and Chinese cohorts

“…20 OCT, a noninvasive and rapid retinal examination, can capture three-dimensional cross-sectional images of the retina and accurately measure the thicknesses of various parts of the retina. 21 Thinning of the RNFL and GCIPL leads to an increased risk of dementia as well as Alzheimer’s disease, and retinal neurodegeneration can be used as a preclinical biomarker for dementia.…”