Nature and Origin of Some Tumors of the Cerebellum

Deregulated expression of PAX5 in medulloblastoma.

“…These precursor cells normally migrate inward during the first 2 years of life to give rise to the differentiated granule neurons of the internal granular layer (4,5). In agreement with the postulated origin in the external granular layer (3), medulloblastomas often display a tendency toward neuronal differentiation in vivo (6, 7).…”

Deregulated expression of PAX5 in medulloblastoma.

“…These precursor cells normally migrate inward during the first 2 years of life to give rise to the differentiated granule neurons of the internal granular layer (4,5). In agreement with the postulated origin in the external granular layer (3), medulloblastomas often display a tendency toward neuronal differentiation in vivo (6, 7).…”

Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants

“…carrot-sha~ed nuclei adult animal, gradually depleting the EGL. The remnants of the fetal EGL have been proposed to be a source of human medulloblastoma progenitors, a hypothesis consistent with the higher frequency of these tumors in children (27).…”

Fetal Cerebellar Tissue Associated with a Primitive Neuro-epithelial Tumor in an Ovarian Teratoma

“…The co-existence of the fetal cerebellar tissue with this medulloblastoma-like tumor might give some indirect support to the external granular cell origin of medulloblastoma hypothesized by several authors. (Kadin et al, 1970;Russel & Rubinstein, 1971;Stevenson & Schlin, 1934).…”

Deregulated expression of PAX5 in medulloblastoma.

“…These precursor cells normally migrate inward during the first 2 years of life to give rise to the differentiated granule neurons of the internal granular layer (4,5). In agreement with the postulated origin in the external granular layer (3), medulloblastomas often display a tendency toward neuronal differentiation in vivo (6, 7).…”

Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants

“…carrot-sha~ed nuclei adult animal, gradually depleting the EGL. The remnants of the fetal EGL have been proposed to be a source of human medulloblastoma progenitors, a hypothesis consistent with the higher frequency of these tumors in children (27).…”

Fetal Cerebellar Tissue Associated with a Primitive Neuro-epithelial Tumor in an Ovarian Teratoma

“…The co-existence of the fetal cerebellar tissue with this medulloblastoma-like tumor might give some indirect support to the external granular cell origin of medulloblastoma hypothesized by several authors. (Kadin et al, 1970;Russel & Rubinstein, 1971;Stevenson & Schlin, 1934).…”

Deregulated expression of PAX5 in medulloblastoma.

“…These precursor cells normally migrate inward during the first 2 years of life to give rise to the differentiated granule neurons of the internal granular layer (4,5). In agreement with the postulated origin in the external granular layer (3), medulloblastomas often display a tendency toward neuronal differentiation in vivo (6, 7).…”

Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants

“…carrot-sha~ed nuclei adult animal, gradually depleting the EGL. The remnants of the fetal EGL have been proposed to be a source of human medulloblastoma progenitors, a hypothesis consistent with the higher frequency of these tumors in children (27).…”

Fetal Cerebellar Tissue Associated with a Primitive Neuro-epithelial Tumor in an Ovarian Teratoma

“…The co-existence of the fetal cerebellar tissue with this medulloblastoma-like tumor might give some indirect support to the external granular cell origin of medulloblastoma hypothesized by several authors. (Kadin et al, 1970;Russel & Rubinstein, 1971;Stevenson & Schlin, 1934).…”