2021
DOI: 10.1073/pnas.2021970118
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Abstract: The frequency and distribution of meiotic crossovers are tightly controlled; however, variation in this process can be observed both within and between species. Using crosses of two natural Arabidopsis thaliana accessions, Col and Ler, we mapped a crossover modifier locus to semidominant polymorphisms in SUPPRESSOR OF NPR1-1 INDUCIBLE 1 (SNI1), which encodes a component of the SMC5/6 complex. The sni1 mutant exhibits a modified pattern of recombination across the genome with crossovers elevated in chromosome d… Show more

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Cited by 16 publications
(14 citation statements)
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“…This is consistent with previous observations in a few crossover reporter intervals and is probably largely driven by an allelic difference in the pro-CO factor HEI10; the Col allele was shown to increase the number of COs compared to the L er allele in a co-dominant manner 50 . Other trans components, such as the SMC5/6 complex subunit SIN1, probably also contribute to the difference in recombination between Col and L er 75 .…”
Section: Discussionmentioning
confidence: 99%
“…This is consistent with previous observations in a few crossover reporter intervals and is probably largely driven by an allelic difference in the pro-CO factor HEI10; the Col allele was shown to increase the number of COs compared to the L er allele in a co-dominant manner 50 . Other trans components, such as the SMC5/6 complex subunit SIN1, probably also contribute to the difference in recombination between Col and L er 75 .…”
Section: Discussionmentioning
confidence: 99%
“…These transcription factors (aligning with peptides 1 and 2), which contain a conserved amino acid motif beginning with WRKY, can be involved in regulating response to a range of biotic and abiotic stresses in plants, including pathogens [ 36 ]. The negative recombination regulator SNI1, which also serves as a defense gene regulator, appears to interact physically with several WRKY transcription factors in Arabidopsis [ 25 , 27 , 36 , 37 ]. Synthesized peptide #30, which was developed from the transcription factor MYC2, also binds RAD51A1 in vitro .…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, RAD51D interacts physically with the defense gene suppressor SNI1 [ 20 , 24 26 ]. SNI1 itself, although first discovered as a negative regulator of defense, is also involved in meiotic recombination; sni1 mutant Arabidopsis displays increased rates of crossover formation [ 27 ]. Adding a maize RAD51A1 transgene to Arabidopsis, rice, or tobacco increases resistance to selected pathogens [ 21 ].…”
Section: Introductionmentioning
confidence: 99%
“…Specifically, the 420 line was used to assess the reshaping of CO frequency patterns along chromosomes due to DNA methylation deficiency, axis formation, and SC mutants, as well as the positive roles of H2A.Z deposition and regional heterozygosity in CO formation ( Choi et al, 2013 ; France et al, 2021 ; Lambing et al, 2020 ; Yelina et al, 2012 ; Ziolkowski et al, 2015 ). Additionally, use of the 420 line led to the identification of HEI10, TAF4B , and SNI1 as natural modifiers of CO frequency with different Arabidopsis accessions ( Lawrence et al, 2019 ; Zhu et al, 2021 ; Ziolkowski et al, 2017 ). Moreover, the 420 seed FTL high-throughput system enabled the forward genetic screening of low or high crossover rate ( lcr or hcr ) mutants using ethyl methanesulfonate mutagenesis ( Kim et al, 2021 ; Nageswaran et al, 2021 ).…”
Section: High-throughput Measurement Of Crossover Frequencymentioning
confidence: 99%
“…The GBS method involves rapid extraction of F 2 individual genomic DNA, sequencing and indexed library construction, and running trained individual genome reconstruction (TIGER), a bioinformatics pipeline used to reconstruct mosaic genomes of F 2 individuals from sparse sequence coverage. Combining GBS with TIGER enabled a precise comparison of the positioning and number of COs in wild-type hybrids with those of diverse genetic backgrounds such as zyp1, asy1, msh2, hcr1, and HEI10 mutants ( Blackwell et al, 2020 ; Capilla-Pérez et al, 2021 ; Kim et al, 2021 ; Lambing et al, 2020 ; Nageswaran et al, 2021 ; Serra et al, 2018a ; Zhu et al, 2021 ). GBS-based CO maps have provided the DNA sequence and chromatin features of CO hotspots in Arabidopsis ( Shilo et al, 2015 ; Wijnker et al, 2013 ).…”
Section: Genome-wide Mapping Of Crossoversmentioning
confidence: 99%