2017
DOI: 10.1101/gad.295501.116
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: During meiosis, homologous chromosomes undergo crossover recombination, which creates genetic diversity and balances homolog segregation. Despite these critical functions, crossover frequency varies extensively within and between species. Although natural crossover recombination modifier loci have been detected in plants, causal genes have remained elusive. Using natural Arabidopsis thaliana accessions, we identified two major recombination quantitative trait loci (rQTLs) that explain 56.9% of crossover variat… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

9
206
1
1

Year Published

2018
2018
2022
2022

Publication Types

Select...
5
3
1

Relationship

1
8

Authors

Journals

citations
Cited by 142 publications
(217 citation statements)
references
References 62 publications
9
206
1
1
Order By: Relevance
“…These included: a SKP1 orthologue (BAnTr.GP.5HG012508) and three F-box proteins (BAnTr.GP.2HG002834, BAnTr.GP.3HG014344, BAnTr.GP.3HG014348) which form part of the multi-subunit SKP Cullin F-box (SCF) E3 ligase complex; one RING-H2 component of the anaphase promoting complex (BAnTr.GP.1HG006974); and three seven-in-absentia (SINA) E3 ligases (BAnTr.GP.2HG018292, BAnTr.GP.3HG000774, BAnTr.GP.3HG000850). HEI10, a highly conserved E3 ubiquitin ligase which is known to be involved in DSB repair (Ziolkowski et al , 2017), was stably expressed in all tissues and stages, including in germinating embryo tissues. Although no NEDD8 E3 ligases are differentially expressed in any stage or tissue comparison, NEDD8-specific protease activity (GO:0019784; P value = 0.00029) is enriched in pachytene–diplotene compared to leptotene–zygotene in anthers.…”
Section: Resultsmentioning
confidence: 99%
“…These included: a SKP1 orthologue (BAnTr.GP.5HG012508) and three F-box proteins (BAnTr.GP.2HG002834, BAnTr.GP.3HG014344, BAnTr.GP.3HG014348) which form part of the multi-subunit SKP Cullin F-box (SCF) E3 ligase complex; one RING-H2 component of the anaphase promoting complex (BAnTr.GP.1HG006974); and three seven-in-absentia (SINA) E3 ligases (BAnTr.GP.2HG018292, BAnTr.GP.3HG000774, BAnTr.GP.3HG000850). HEI10, a highly conserved E3 ubiquitin ligase which is known to be involved in DSB repair (Ziolkowski et al , 2017), was stably expressed in all tissues and stages, including in germinating embryo tissues. Although no NEDD8 E3 ligases are differentially expressed in any stage or tissue comparison, NEDD8-specific protease activity (GO:0019784; P value = 0.00029) is enriched in pachytene–diplotene compared to leptotene–zygotene in anthers.…”
Section: Resultsmentioning
confidence: 99%
“…Intra‐species variability in the recombination rate observed for plants and animals (Dvorák and McGuire, ; Lynn et al ., ; Esch et al ., ; Pradillo et al ., ; Bauer et al ., ; Dreissig et al ., ; Ziolkowski et al ., ) was shown to be affected by both genes controlling meiotic division and the distribution of local genomic features and/or chromatin structure (Akhunov et al ., ; Yandeau‐Nelson et al ., ; Liu et al ., ; Wijnker et al ., ; Rodgers‐Melnick et al ., ; Shilo et al ., ; Melamed‐bessudo et al ., ). Meiotically induced double‐stranded breaks (DSBs) are repaired through pathways resulting in either crossover (CO) or non‐crossover events, which can be detected when the interaction of the DSB region occurs between non‐sister chromatids (Mercier et al ., ).…”
Section: Introductionmentioning
confidence: 99%
“…In plants over 80 genes have been identified and characterized that are involved in recombination including crossover and gene conversion formation (Mercier et al, 2015;Fernandes et al, 2018;Ziolkowski et al, 2017;Girard et al 2015;Segulea-Arnaud et al, 2015). For example, in Arabidopsis, Ziolkowski et al (2017) found that the HEI10 meiotic E3 ligase could control crossover recombination. Recombination rates can also be variable; between populations, within a population and even within a chromosome of a single organism (Schnable et al, 1998;Esch et al, 2007).…”
mentioning
confidence: 99%