Natural Terpenoids as Neuroinflammatory Inhibitors in LPS-stimulated BV-2 Microglia

Xu, Yuanzhen; Wei, Hongbo; Gao, Jin‐Ming

doi:10.2174/1389557519666190611124539

Cited by 12 publications

(11 citation statements)

References 118 publications

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“…Experimental and clinical studies have suggested the beneficial effects of herbal medicine in neurodegenerative conditions. − Previous studies have indicated that plant-derived terpenoids positively affect neurodegeneration . BAs are triterpenoid and hydrophobic compounds extracted from the resin of Boswellia plant species and they possess anti-inflammatory, antioxidant, and antiedema properties. − It has been shown that BA can ameliorate memory deficit in animal AD models .…”

Section: Introductionmentioning

confidence: 99%

Inhibition Of Tau Protein Aggregation By a Chaperone-like β-Boswellic Acid Conjugated To Gold Nanoparticles

Gharb

Nouralishahi

Riazi³

et al. 2022

ACS Omega

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A potential therapeutic strategy to inhibit tau protein aggregation in neurons has substantial effects on preventing or controlling Alzheimer’s disease (AD). In this work, we designed a covalent and noncovalent conjugation of β-boswellic acid (BA) to gold nanoparticles (GNPs). We provided the opportunity to investigate the effect of the surface composition of BA-GNPs on the aggregation of the tau protein 1N/4R isoform in vitro. HR-TEM and FESEM micrographs revealed that GNPs were spherical and uniform, smaller than 25 nm. According to UV–visible and FTIR data, BA was successfully conjugated to GNPs. The finding illustrates the effect of the surface charge, size, and hydrophobicity of BA-GNPs on the kinetics of tau protein aggregation. The size and surface area of U-G-BA demonstrated that inhibited tau aggregation more effectively than covalently linked BA. The proposed method for preventing tau aggregation was monomer reduction. At the same time, a chaperone-like feature of GNP-BA while sustaining a tau native structure prevented the additional formation of fibrils. Overall, this study provides insight into the interaction of GNP-BAs with a monomer of tau protein and may suggest novel future therapies for AD.

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Section: Introductionmentioning

confidence: 99%

Inhibition Of Tau Protein Aggregation By a Chaperone-like β-Boswellic Acid Conjugated To Gold Nanoparticles

Gharb

Nouralishahi

Riazi³

et al. 2022

ACS Omega

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“…Though PD is a subject of great concern, its exact etiology remains unclear. Researchers have postulated that oxidative stress, mitochondrial dysfunction, neuroinflammation, and apoptosis lead to DA neuronal damage. − In PD, progressive loss of DA neurons occurs in the substantia nigra pars compacta. Human monoamine oxidase (hMAO) is a flavoenzyme that catalyzes the oxidative deamination of various bioamines; its inhibitors were the first developed antidepressants.…”

Section: Introductionmentioning

confidence: 99%

In Vitro and in Silico Human Monoamine Oxidase Inhibitory Potential of Anthraquinones, Naphthopyrones, and Naphthalenic Lactones from Cassia obtusifolia Linn Seeds

et al. 2019

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In recent years, Cassia seed extract has been reported as a neuroprotective agent in various models of neurodegeneration, mainly via an antioxidant mechanism. However, no one has previously reported the effects of Cassia seed extract and its phytochemicals on human monoamine oxidase (hMAO) enzyme activity. The seed methanol extract, the solvent-soluble fractions, and almost all isolated compounds displayed selective inhibition of hMAO-A isozyme activity. Interestingly, compounds obtusin (3), alaternin (8), aloe-emodin (9), questin (12), rubrofusarin (13), cassiaside (15), toralactone 9-O-β-gentiobioside (26), and (3S)-9,10-dihydroxy-7-methoxy-3-methyl-1-oxo-3,4-dihydro-1H-benzo[g]isochromene-3-carboxylic acid 9-O-β-d-glucopyranoside (38) showed the most promising inhibition of the hMAO-A isozyme with IC50 values of 0.17–11 μM. The kinetic study characterized their mode of inhibition and molecular docking simulation predicted interactions with Ile-335 and Tyr-326 in support of the substrate/inhibitor selectivity in respective isozymes. These results demonstrate that Cassia seed extract and its constituents inhibit hMAO-A enzyme activity with high selectivity and suggest that they could play a preventive role in neurodegenerative diseases, especially anxiety and depression.

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“…Three distinct methods have been employed to induce parkinsonism using LPS injection: intraperitoneal (i.p), intranasal, and intrastriatal (Bai et al, 2023;Deng et al, 2020;García-Revilla et al, 2022). All these techniques resulted in the degeneration of nigrostriatal dopaminergic neurons, motor dysfunction, and α-synuclein aggregation (Deng et al, 2020;Martins, 2015;Xu et al, 2021). However, from our observations, the intrastriatal injection of LPS exhibited a higher success rate and faster induction of parkinsonism.…”

Section: Discussionmentioning

confidence: 77%

GM3 Ganglioside’s Efficacy in LPS-Induced Parkinsonism: Neuroprotection and Gliosis Mitigation

Liu,

Fann,

et al. 2023

Preprint

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Background: Parkinson’s disease (PD) continues to be a neurological challenge with limited therapeutic options. This study aimed to investigate the potential therapeutic effects of GM3 ganglioside, focusing on its role in mitigating LPS-induced parkinsonism behaviors, gliosis, and neurotoxicity. Methods: We employed a range of in vivo tests, including rotarod and beam-walking, to assess motor function improvements in LPS-induced parkinsonism following GM3 ganglioside pre-treatment. Dopaminergic neurotoxicity was examined using [18F]FE-PE2I PET imaging and TH staining of the striatum. Further, we investigated the impact of GM3 ganglioside on LPS-induced gliosis by observing changes in microglial activation and astrocytic proliferation. Results: Pre-treatment with GM3 ganglioside significantly improved motor functions, as evidenced by enhanced performance in rotarod and beam-walking tests. Our findings also showcased GM3 ganglioside’s efficacy in countering LPS-induced dopaminergic neurotoxicity, with [18F]FE-PE2I PET imaging and TH staining supporting its neuroprotective potential. Importantly, GM3 ganglioside pre-treatment notably reduced LPS-induced gliosis, demonstrating a significant decrease in both microglial activation and astrocytic proliferation. Conclusions: GM3 ganglioside presents promising neuroprotective capabilities, effectively mitigating LPS-induced parkinsonism behaviors and gliosis. These findings underscore GM3 ganglioside’s potential as a valuable therapeutic avenue for future Parkinson’s disease interventions.

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Natural Terpenoids as Neuroinflammatory Inhibitors in LPS-stimulated BV-2 Microglia

Cited by 12 publications

References 118 publications

Inhibition Of Tau Protein Aggregation By a Chaperone-like β-Boswellic Acid Conjugated To Gold Nanoparticles

Inhibition Of Tau Protein Aggregation By a Chaperone-like β-Boswellic Acid Conjugated To Gold Nanoparticles

In Vitro and in Silico Human Monoamine Oxidase Inhibitory Potential of Anthraquinones, Naphthopyrones, and Naphthalenic Lactones from Cassia obtusifolia Linn Seeds

GM3 Ganglioside’s Efficacy in LPS-Induced Parkinsonism: Neuroprotection and Gliosis Mitigation

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