Natural products modulating interleukins and other inflammatory mediators in tumor-bearing animals: A systematic review

Gandhi, Gopalsamy Rajiv; Antony, Poovathumkal James; Lana, Maria Júlia Miranda de Paula; Silva, Brenda Fernandes Xavier da; Oliveira, Roberta Vieira; Jothi, Gnanasekaran; Hariharan, Govindasamy; Mohana, Thiruchenduran; Gan, Ren‐You; Gurgel, Ricardo Queiróz; Cipolotti, Rosana; Quintans‐Júnior, Lucindo José

doi:10.1016/j.phymed.2022.154038

Cited by 10 publications

(14 citation statements)

References 78 publications

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“…are non-specific immune mechanisms that can become chronic and are linked to specific conditions such as cardiovascular disease, cancer, arthritis or allergy. Within this context, a plethora of vegetal matrices have been investigated, searching for compounds that exert immune-modulatory or anti-inflammatory properties [ 90 ].…”

Section: Anti-inflammatory/immune-modulatory Activitymentioning

confidence: 99%

Use of Strawberry Tree (Arbutus unedo) as a Source of Functional Fractions with Biological Activities

Morales

2022

Foods

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Arbutus unedo, commonly named ‘strawberry tree’ (ST), is a Mediterranean native plant that represents a relevant source of biologically active fractions and compounds. ST fruits, traditionally used with culinary and medicinal purposes, along with other components (leaves, roots, honeys, etc.), have been subjected to varied extraction procedures to obtain enriched and bioactive products. This work reviewed the scientific literature, searching for studies that evaluated the potential health implications of ST fractions and attending to the tested biological activities (antioxidant, antiproliferative, hypoglycemic, immune-modulatory, antihypertensive, antimicrobial, etc.), the part of the tree, the experimental model, the specific bioactive compounds and the selected extraction protocol. Furthermore, the strengths and weaknesses of the current state of the published evidence were critically analysed. Although in vitro results demonstrated the potential of ST fractions, further research is encouraged in order to obtain in vivo evidence (animal and clinical studies), assess additional activities (hypocholesterolemic, microbiome-modulatory), maximize the use of advanced extraction technologies, purify and isolate specific bioactive compounds and broaden the analysis investigating phenolic and non-phenolic molecules and their bioavailability.

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Section: Anti-inflammatory/immune-modulatory Activitymentioning

confidence: 99%

Use of Strawberry Tree (Arbutus unedo) as a Source of Functional Fractions with Biological Activities

Morales

2022

Foods

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“…The most-used drugs in clinical practice for inflammation are synthetic non-steroidal anti-inflammatory drugs (NSAIDs); however, they have multiple side effects and complications, which weaken the overall potential of this anti-inflammatory treatment [6,7]. Natural plant extracts are sources of high-quality phytochemicals and novel bioactive molecules with important antioxidant and anti-inflammatory effects and could be used in the development of new drugs for the treatment and prevention of inflammatory diseases [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Anti-Neuroinflammatory Potential of a Nectandra angustifolia (Laurel Amarillo) Ethanolic Extract

et al. 2023

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Microglia, the resident macrophage-like population in the CNS, plays an important role in the pathogenesis of many neurodegenerative disorders. Nectandra genus is known to produce different metabolites with anti-inflammatory, anti-oxidant and analgesic properties. Although the species Nectandra angustifolia is popularly used for the treatment of different types of inflammatory processes, its biological effects on neuroinflammation have not yet been addressed. In this study, we have investigated the role of a Nectandra angustifolia ethanolic extract (NaE) in lipopolysaccharide (LPS)-induced neuroinflammation in vitro and in vivo. In LPS-activated BV2 microglial cells, NaE significantly reduced the induced proinflammatory mediators TNF-α, IL-1β, IL-6, COX-2 and iNOS, as well as NO accumulation, while it promoted IL-10 secretion and YM-1 expression. Likewise, reduced CD14 expression levels were detected in microglial cells in the NaE+LPS group. NaE also attenuated LPS-induced ROS and lipid peroxidation build-up in BV2 cells. Mechanistically, NaE prevented NF-κB and MAPKs phosphorylation, as well as NLRP3 upregulation when added before LPS stimulation, although it did not affect the level of some proteins related to antioxidant defense such as Keap-1 and HO-1. Additionally, we observed that NaE modulated some activated microglia functions, decreasing cell migration, without affecting their phagocytic capabilities. In LPS-injected mice, NaE pre-treatment markedly suppressed the up-regulated TNF-α, IL-6 and IL-1β mRNA expression induced by LPS in brain. Our findings indicate that NaE is beneficial in preventing the neuroinflammatory response both in vivo and in vitro. NaE may regulate microglia homeostasis, not only restraining activation of LPS towards the M1 phenotype but promoting an M2 phenotype.

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“…It has been reported that cells or mice Nutrients 2022, 14, 5281 2 of 13 exposed to MNNG promote the EMT process. Cancer is also characterized by abnormal cell proliferation [12,13]. Studies indicate that exposure to MNNG induces cell proliferation [14,15].…”

Section: Introductionmentioning

confidence: 99%

Hesperidin Reversed Long-Term N-methyl-N-nitro-N-Nitroguanidine Exposure Induced EMT and Cell Proliferation by Activating Autophagy in Gastric Tissues of Rats

Liang

Song

et al. 2022

Nutrients

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Gastric cancer is a common malignant tumor worldwide. N-methyl-N-nitro-N-nitroguanidine (MNNG) is one of the most important inducing factors of gastric cancer. Autophagy can affect the occurrence and development of gastric cancer, but the mechanism is not clear. Chemoprevention has been shown to be a rational and very promising approach to the prevention of gastric cancer. Hesperidin is a citrus flavone, an abundant polyphenol in citrus fruits and traditional Chinese medicine. It has an excellent phytochemistry that plays an intervention role in gastric cancer. However, it is unclear whether long-term exposure to MNNG will affect the occurrence of gastric cancer by regulating autophagy and whether hesperidin can play an intervention role in this process. In the present study, we demonstrated that long-term MNNG exposure inhibits autophagy in stomach tissues of rats, promotes the epithelial–mesenchymal transition (EMT) process and cell proliferation and suppresses the activity of the PI3K/AKT pathway. We further found that after rapamycin-activated autophagy, long-term MNNG exposure promoted cell proliferation and EMT were inhibited. In addition, hesperidin promotes autophagy and the activity of the PI3K/AKT pathway, as well as the suppression of proliferation and EMT in the stomach tissues of rats. Our findings indicate that hesperidin reverses MNNG-induced gastric cancer by activating autophagy and the PI3K/AKT pathway, which may provide a new basis for the early prevention and treatment of MNNG-induced gastric cancer.

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Natural products modulating interleukins and other inflammatory mediators in tumor-bearing animals: A systematic review

Cited by 10 publications

References 78 publications

Use of Strawberry Tree (Arbutus unedo) as a Source of Functional Fractions with Biological Activities

Use of Strawberry Tree (Arbutus unedo) as a Source of Functional Fractions with Biological Activities

Anti-Neuroinflammatory Potential of a Nectandra angustifolia (Laurel Amarillo) Ethanolic Extract

Hesperidin Reversed Long-Term N-methyl-N-nitro-N-Nitroguanidine Exposure Induced EMT and Cell Proliferation by Activating Autophagy in Gastric Tissues of Rats

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