Natural products derived from plants as a source of drugs

Veeresham, Ciddi

doi:10.4103/2231-4040.104709

Cited by 635 publications

(417 citation statements)

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“…Overall, the practice of natural medication employing herbs are globally accepted in respect to the treatment efficiency with minute side effects [11,16,19,20,21,22,23]. The anti-bacterial activities as found in the current investigation both in case of imported and local fruit extracts further demonstrate the therapeutic value of natural products.…”

Section: Discussionmentioning

confidence: 57%

“…The increased nutritional benefits with least side effects of fruits promoted their use for medicinal purposes regarding the regulated management of public health [18][19][20][21][22][23][24][25]. As stated earlier, the incidence of drug resistance has risen in recent times not only due the natural dissemination of resistance genes but also because of excess use and abuse of antimicrobial drugs [14,15,16,17,18].…”

Section: Discussionmentioning

confidence: 99%

“…Such a situation could demand for alternative natural medication approaches with least toxicity and side effects [18][19][20][21][22][23][24][25]. In Bangladesh, an array of medicinal plants have so far been reported with their effectiveness; however, work on fruits is still insignificant [19].…”

Section: Introductionmentioning

confidence: 99%

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Demonstration of Anti-Bacterial Activity of commonly available Fruit Extracts in Dhaka, Bangladesh

Tahera¹,

Feroz²,

Senjuti³

et al. 2014

AJMR

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Present study attempted to determine the antimicrobial activity of extracts from commonly consumed fruits including guava (Psidium guajava), malta (Citrus sinensis), apple (Malus domestica), orange (Citrus reticulate) and dragon fruit (Hylocereus polyrhizus) against Bacillus spp., Pseudomonas spp., Vibrio spp., Escherichia coli, Klebsiella spp., Staphylococcus spp., Listeria spp., Salmonella spp., and Aeromonas spp. Of the fruits examined, malta and orange samples were observed to be most effective against the test organisms, whereas dragon fruit was the least effective one. Among all the bacteria tested, Bacillus spp. seemed to be most susceptible to the antibacterial activity of the fruits, whereas Aeromonas spp. seemed to be the most resistant one. No significant difference in antimicrobial activity was observed among the imported and local fruit extracts.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

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Demonstration of Anti-Bacterial Activity of commonly available Fruit Extracts in Dhaka, Bangladesh

Tahera¹,

Feroz²,

Senjuti³

et al. 2014

AJMR

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“…Although the use of bioactive natural products as herbal drug preparations dates back thousand of years ago, their application as isolated and characterized compounds to modern drug discovery and development started only in the 19th century. 5 Many plant extracts, which are tested for their suggested applications are available as prescription drugs in Europe. …”

Section: Introductionmentioning

confidence: 99%

Effect of ethyl acetate extract of Melothria perpusilla on intestinal absorption of glucose in albino rats

Singh

Usham

Akham

et al. 2017

Int J Basic Clin Pharmacol

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Background: Diabetes mellitus is a spectrum of conditions that includes hyperglycemia. Safety issues limit the optimal use of anti diabetic drugs. The objectives of the study were to evaluate the effect of ethyl acetate extract of Melothria perpusilla (EAEMP) on intestinal absorption of glucose in albino rats.Methods: Twenty four healthy albino rats were divided into four groups (control, standard, test I and test II) of six animals each weighing between 120-150g. Animals in control group were fed with 2% gum acacia, standard group with metformin 150mg/kg, test I with 250mg/kg of EAEMP and test II with 500mg/kg of EAEMP. After treatment for seven days, rats were fasted overnight. Intestinal loop of 10 cm from the pyloric end was prepared, keeping the blood supply intact under anaesthesia. One ml of 250mg% D-glucose in normal saline was injected in the lumen of loop. Rats were sacrificed and the loop was removed after 15minutes. Weight of excised loop was measured and fluid was recovered. The glucose absorbed was calculated by the difference between the amount introduced and recovered after the absorptive period. After dehydrating, the dry weight of the tissue segment was measured. Intestinal glucose absorption was expressed in mg/g dry weight tissue/h.Results: The non parametric data were analysed by Kruskal Wallis test. Ethyl acetate extract of Melothria perpusilla produced a significant reduction in intestinal glucose absorption when compared with control and standard.Conclusions: Treatment with Melothria perpusilla inhibits intestinal glucose absorption probably by inhibition of flavonoids on Na+-K+ATPase.

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“…To combat such problems associated with the antibiotic usage, natural products are being recently explored for their strong anti-bacterial activity without any side effects (11,18,19). Along with proven medicinal plants, fresh fruits are being widely studied now-a-days for medications against pathogenic organisms as they have been reported to possess many of the known phytochemicals capable of performing an array of beneficiary biological functions including anti-bacterial activities (19)(20)(21)(22)(23).…”

mentioning

confidence: 99%

Investigation of microbiological spoilage and demonstration of the anti-bacterial activity of the major imported fruits within Dhaka Metropolis

Noor

2015

S.J. Microbiol.

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1With a previous observation of the in vitro anti-bacterial traits posed by both local and imported fruit alcoholic extracts, present study further endeavored principally to chalk out such properties of the imported fruit blends without alcoholic extraction. Experiments regarding microbiological load demonstrated the prevalence of huge number of total viable bacteria (~10 7 cfu/g) as was also observed in the earlier research while the fungal load was nominal. Among the pathogenic bacteria, Pseudomonas spp. was found to be more prevalent, closely followed by staphylococcal proliferation. The study of anti-bacterial activity revealed that guava, apple and malta samples possessed strong antibacterial traits while the dragon fruit samples exhibited least activity and the orange samples were found with moderate anti-bacterial activity. On the basis of our earlier results, the findings of the current study thus put forward a comparison among the alcoholic extracts and the crude fruit blends.

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Natural products derived from plants as a source of drugs

Cited by 635 publications

References 0 publications

Demonstration of Anti-Bacterial Activity of commonly available Fruit Extracts in Dhaka, Bangladesh

Demonstration of Anti-Bacterial Activity of commonly available Fruit Extracts in Dhaka, Bangladesh

Effect of ethyl acetate extract of Melothria perpusilla on intestinal absorption of glucose in albino rats

Investigation of microbiological spoilage and demonstration of the anti-bacterial activity of the major imported fruits within Dhaka Metropolis

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