Natural Product Modulators to Overcome Multidrug Resistance In Cancer

Çört, Ayşegül; Özben, Tomris

doi:10.1080/01635581.2015.1002624

Cited by 49 publications

(39 citation statements)

References 137 publications

(133 reference statements)

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“…The beneficial activity of natural modulators on ABC transporters is mainly associated with synergism with other anti-tumor drugs. Natural compounds can act as competitors of active sites of efflux pumps, reducing the chemotherapeutic efflux [61]. Among the class of secondary metabolites, flavonoids stand out as efflux pump inhibitors particularly because they inhibit P-gp ATP-ase activity by interacting with the ATP-binding sites [62, 63].…”

Section: Phytometabolites Targeting Cscs Modulate Abc Transporters Kmentioning

confidence: 99%

Anti-Cancer Phytometabolites Targeting Cancer Stem Cells

Torquato

Goettert²,

Justo³

et al. 2017

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Medicinal plants are a plentiful source of bioactive molecules with much structural diversity. In cancer treatment, molecules obtained from plants represent an attractive alternative to other treatments because several plant-derived compounds have exhibited lower toxicity and higher selectivity against cancer cells. In this review, we focus on the possible application of bioactive molecules obtained from plants against more primitive cell populations in cancers, cancer stem cells. Cancer stem cells are present in several kinds of tumors and are responsible for recurrences and metastases. Common anti-cancer drugs exhibit lower effectiveness against cancer stem cells because of their biological features. However, recently discovered natural phytometabolites exert cytotoxic effects on this rare population of cells in cancers. Therefore, this review presents the latest research on promising compounds from plants that can act as antitumor drugs and that mainly affect stem cell populations in cancers.

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Section: Phytometabolites Targeting Cscs Modulate Abc Transporters Kmentioning

confidence: 99%

Anti-Cancer Phytometabolites Targeting Cancer Stem Cells

Torquato

Goettert²,

Justo³

et al. 2017

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“…presented within the cancer cell membrane is associate with MDR 113–115 . In many cancer types, nearly 40–50% of the patients diagnosed with cancer have ABCs overexpression in the malignant tissue 116, 117 .…”

Section: Use Peg-based Amphiphilic Nanostructures To Overcome Chemmentioning

confidence: 99%

Targeting tumor microenvironment with PEG-based amphiphilic nanoparticles to overcome chemoresistance

Chen

Yang

Tuguntaev

et al. 2016

Nanomedicine: Nanotechnology, Biology and Medicine

104

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Multidrug resistance is one of the biggest obstacles in the treatment of cancer. Several factors involves in drug resistance including enhanced repair mechanisms of drug induced DNA damage, lowered tumor extracellular pH, alteration of cell cycle check points, blockage of apoptosis pathway, poor tumor vasculature and over expression of drug efflux pumps. Recent research studies highlight that tumor microenvironment plays a predominant role in tumor cell proliferation and metastasis. Hence, targeting the tumor microenvironment provides a novel strategy for the evolution of cancer nanomedicine. The blooming knowledge about the tumor microenvironment merging with the design of PEG-based amphiphilic nanoparticles can provide an effective and promising platform to address the multidrug resistant tumor cells. This review describes the characteristic features of tumor microenvironment and their targeting mechanisms with the aid of PEG-based amphiphilic nanoparticles for the development of newer drug delivery systems to overcome multidrug resistance in cancer cells.

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“…These authors further report that tumor microenvironment‐induced selection pressure leads to the development of intrinsic MDR, while acquired resistance is a consequence of chronic chemotherapy administrations. Cort and Ozben as well as Dinic et al . state that natural product‐based drugs are important in overcoming or reversing MDR in cancer therapy.…”

Section: Introductionmentioning

confidence: 88%

Marine Mollusk‐Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance

Ciavatta

Lefranc

Carbone

et al. 2016

Medicinal Research Reviews

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The chemical investigation of marine mollusks has led to the isolation of a wide variety of bioactive metabolites, which evolved in marine organisms as favorable adaptations to survive in different environments. Most of them are derived from food sources, but they can be also biosynthesized de novo by the mollusks themselves, or produced by symbionts. Consequently, the isolated compounds cannot be strictly considered as “chemotaxonomic markers” for the different molluscan species. However, the chemical investigation of this phylum has provided many compounds of interest as potential anticancer drugs that assume particular importance in the light of the growing literature on cancer biology and chemotherapy. The current review highlights the diversity of chemical structures, mechanisms of action, and, most importantly, the potential of mollusk‐derived metabolites as anticancer agents, including those biosynthesized by mollusks and those of dietary origin. After the discussion of dolastatins and kahalalides, compounds previously studied in clinical trials, the review covers potentially promising anticancer agents, which are grouped based on their structural type and include terpenes, steroids, peptides, polyketides and nitrogen‐containing compounds. The “promise” of a mollusk‐derived natural product as an anticancer agent is evaluated on the basis of its ability to target biological characteristics of cancer cells responsible for poor treatment outcomes. These characteristics include high antiproliferative potency against cancer cells in vitro, preferential inhibition of the proliferation of cancer cells over normal ones, mechanism of action via nonapoptotic signaling pathways, circumvention of multidrug resistance phenotype, and high activity in vivo, among others. The review also includes sections on the targeted delivery of mollusk‐derived anticancer agents and solutions to their procurement in quantity.

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Natural Product Modulators to Overcome Multidrug Resistance In Cancer

Cited by 49 publications

References 137 publications

Anti-Cancer Phytometabolites Targeting Cancer Stem Cells

Anti-Cancer Phytometabolites Targeting Cancer Stem Cells

Targeting tumor microenvironment with PEG-based amphiphilic nanoparticles to overcome chemoresistance

Marine Mollusk‐Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance

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