Natural product–based nanomedicine: polymeric nanoparticles as delivery cargoes of food bioactives and nutraceuticals for anticancer purposes

Cadoná, Francine Carla; Machado, Alencar Kolinski; Bodenstein, David; Rossoni, Carina; Favarin, Fernanda Reis; Ourique, Aline Ferreira

doi:10.1016/b978-0-12-819666-3.00002-x

Cited by 5 publications

(3 citation statements)

References 160 publications

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“…Apigenin has been connected to having an antitumor effect against a broad spectrum of cancers. This effect is thought to be achieved through apoptosis and autophagy stimulation, cell cycle arrest, inhibition of cell migration and invasion, and an increase in immunological response 37 , 38 , and it may demonstrated to be capable of preventing, inhibiting, or reversing the effects of chemically induced genotoxicity in vitro cell models, in vivo investigations, and AMES tests employing bacterial models. This anti-mutagenic effect has been demonstrated and proven.…”

Section: Literature Studies and Ligand-receptor Selection Criteriamentioning

confidence: 99%

Novel computational and drug design strategies for inhibition of human papillomavirus-associated cervical cancer and DNA polymerase theta receptor by Apigenin derivatives

Akash,

Bayıl,

Hossain

et al. 2023

Sci Rep

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The present study deals with the advanced in-silico analyses of several Apigenin derivatives to explore human papillomavirus-associated cervical cancer and DNA polymerase theta inhibitor properties by molecular docking, molecular dynamics, QSAR, drug-likeness, PCA, a dynamic cross-correlation matrix and quantum calculation properties. The initial literature study revealed the potent antimicrobial and anticancer properties of Apigenin, prompting the selection of its potential derivatives to investigate their abilities as inhibitors of human papillomavirus-associated cervical cancer and DNA polymerase theta. In silico molecular docking was employed to streamline the findings, revealing promising energy-binding interactions between all Apigenin derivatives and the targeted proteins. Notably, Apigenin 4′-O-Rhamnoside and Apigenin-4′-Alpha-l-Rhamnoside demonstrated higher potency against the HPV45 oncoprotein E7 (PDB ID 2EWL), while Apigenin and Apigenin 5-O-Beta-d-Glucopyranoside exhibited significant binding energy against the L1 protein in humans. Similarly, a binding affinity range of − 7.5 kcal/mol to − 8.8 kcal/mol was achieved against DNA polymerase theta, indicating the potential of Apigenin derivatives to inhibit this enzyme (PDB ID 8E23). This finding was further validated through molecular dynamic simulation for 100 ns, analyzing parameters such as RMSD, RMSF, SASA, H-bond, and RoG profiles. The results demonstrated the stability of the selected compounds during the simulation. After passing the stability testing, the compounds underwent screening for ADMET, pharmacokinetics, and drug-likeness properties, fulfilling all the necessary criteria. QSAR, PCA, dynamic cross-correlation matrix, and quantum calculations were conducted, yielding satisfactory outcomes. Since this study utilized in silico computational approaches and obtained outstanding results, further validation is crucial. Therefore, additional wet-lab experiments should be conducted under in vivo and in vitro conditions to confirm the findings.

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Section: Literature Studies and Ligand-receptor Selection Criteriamentioning

confidence: 99%

Novel computational and drug design strategies for inhibition of human papillomavirus-associated cervical cancer and DNA polymerase theta receptor by Apigenin derivatives

Akash,

Bayıl,

Hossain

et al. 2023

Sci Rep

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“…Theobromine is a distinctive compound found in cocoa plants, including the husk. This compound was only identified in the acetone fraction and is known for its anticancer activity [26]. The methanol fraction contains several potent antioxidants, such as Tetradecanoic acid, Oleic acid, Octadecanoic acid, Stigmasterol, and gamma-sitosterol.…”

Section: Chemical Compounds Analysismentioning

confidence: 99%

Comparative analysis of total flavonoid, total phenolic content, and antioxidant activity of Theobroma cacao Pod Husk extract and its derived fractions

Hartanti,

Iwan Sariyanto

2023

GSC Biol. Pharm. Sci.

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Secondary metabolites from plants are known to be promising sources of raw materials for drugs in terms of safety. This research focuses on cacao pod husk as a candidate for discovering natural antioxidant compounds. The stages in this study include the extraction of cacao pod husk using methanol as a solvent, followed by liquid-liquid fractionation to produce ethyl acetate and acetone fractions. Subsequently, total flavonoid and phenolic content, DPPH antioxidant activity tests, and GCMS metabolite analysis were conducted. The research results indicate that the ethyl acetate fraction has the highest total flavonoid and phenolic content compared to methanol extract and acetone fraction. The methanol extract has the highest antioxidant activity with an IC50 of 0.0736 mg/mL. The identified metabolites belong to the groups of polyphenols, flavonoids, steroids, and their derivatives, as well as some volatile compounds such as hexadecanoic acid methyl ester. Compounds with potential antioxidant properties include Eugenol, Myristicine, Piperine, and Theobromine.

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“…Natural product-based materials are currently considered to be the key ingredients in the preparation and processing of new nanoformulations as they have interesting features such as biodegradability, biocompatibility, availability, renewability and low toxicity [85,86,87]. In addition to the aforementioned properties, biomaterials are largely capable of undergoing chemical modifications, ensuring unique and desirable Nanomedicines: Nano based Drug Delivery Systems Challenges and Opportunities DOI: http://dx.doi.org /10.5772/intechopen.94353 properties for potential nanomedicine uses [88,89].…”

Section: Natural Product Based Drug Delivery Systemmentioning

confidence: 99%

Nanomedicines: Nano based Drug Delivery Systems Challenges and Opportunities

Hamid¹,

Manzoor²

2021

Alternative Medicine - Update

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Nanomedicine and nano delivery systems, although relatively recent but fast-developing technology is one where nanoscale materials are used to function as diagnostic tools or to deliver therapeutic agents to specifically targeted sites in a controlled manner. It also provides many advantages in the management of human diseases. Recently, there has been a range of excellent uses of nanomedicine as chemotherapeutic agents, biological agents, immunotherapeutic agents, etc., for treatment of different diseases. In this chapter we discuss the recent developments and insights obtained in the field of nanomedicine. It provides a review of the numerous nano-based drug delivery systems that enhance the efficacy of new and old drugs. The new opportunities and challenges arising in the area of nanomedicine from therapeutic viewpoint are also addressed.

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Natural product–based nanomedicine: polymeric nanoparticles as delivery cargoes of food bioactives and nutraceuticals for anticancer purposes

Cited by 5 publications

References 160 publications

Novel computational and drug design strategies for inhibition of human papillomavirus-associated cervical cancer and DNA polymerase theta receptor by Apigenin derivatives

Novel computational and drug design strategies for inhibition of human papillomavirus-associated cervical cancer and DNA polymerase theta receptor by Apigenin derivatives

Comparative analysis of total flavonoid, total phenolic content, and antioxidant activity of Theobroma cacao Pod Husk extract and its derived fractions

Nanomedicines: Nano based Drug Delivery Systems Challenges and Opportunities

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