Natural product-based design, synthesis and biological evaluation of 2′,3,4,4′-tetrahydrochalcone analogues as antivitiligo agents

Zhong, Hui; Zhou, Jia; An, Xiaohong; Hua, Yingrong; Lai, Yifan; Zhang, Rui; Ahmad, Owais; Zhang, Ye; Shang, Jing

doi:10.1016/j.bioorg.2019.03.054

Cited by 6 publications

(10 citation statements)

References 31 publications

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“…Its analogue, RY3-c, has better melanogenesis and antioxidant activity and lower toxicity. Mechanistic studies have shown that RY3-c can repair cell damage caused by excessive oxidative stress by activating the MAPK pathway [ 99 ]. Further, flumequine can induce an increase in the melanin content of zebrafish larvae and B16F10 cells by activating p38 MAPK and c-Jun N-terminal kinase (JNK), and this has the potential for use as an antivitiligo drug [ 100 ].…”

Section: Oxidative Stress and Vitiligomentioning

confidence: 99%

Research Progress on Targeted Antioxidant Therapy and Vitiligo

Zhang

Wang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Vitiligo is a common acquired depigmenting disease characterized by the loss of functional melanocytes and epidermal melanin. Vitiligo has a long treatment cycle and slow results, which is one of the most difficult challenges for skin diseases. Oxidative stress plays an important role as an initiating and driving factor in the pathogenesis of vitiligo. Antioxidant therapy has recently become a research hotspot in vitiligo treatment. A series of antioxidants has been discovered and applied to the treatment of vitiligo, which has returned satisfactory results. This article briefly reviews the relationship between oxidative stress and vitiligo. We also describe the progress of targeted antioxidant therapy in vitiligo, with the aim of providing a reference for new drug development and treatment options for this condition.

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Section: Oxidative Stress and Vitiligomentioning

confidence: 99%

Research Progress on Targeted Antioxidant Therapy and Vitiligo

Zhang

Wang

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…Tazemetostat has been recently approved for relapsed/refractory after two or more lines of therapy in the presence of an EZH2 mutation or independent of an EZH2 mutation in the absence of other options ( 82 ). Combined tazemetostat and MAPKis enhances the differentiation of papillary thyroid cancer cells harboring BRAFV600E by synergistically decreasing the global trimethylation of H3K27me ( 44 ). UNC1999, a modified inhibitor, improves the specificity of EZH2 and achieves better oral bioavailability ( 83 ).…”

Section: Histone Methylation As An Anticancer Targetmentioning

confidence: 99%

Targeting Epigenetic Regulatory Enzymes for Cancer Therapeutics: Novel Small-Molecule Epidrug Development

et al. 2022

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Dysregulation of the epigenetic enzyme-mediated transcription of oncogenes or tumor suppressor genes is closely associated with the occurrence, progression, and prognosis of tumors. Based on the reversibility of epigenetic mechanisms, small-molecule compounds that target epigenetic regulation have become promising therapeutics. These compounds target epigenetic regulatory enzymes, including DNA methylases, histone modifiers (methylation and acetylation), enzymes that specifically recognize post-translational modifications, chromatin-remodeling enzymes, and post-transcriptional regulators. Few compounds have been used in clinical trials and exhibit certain therapeutic effects. Herein, we summarize the classification and therapeutic roles of compounds that target epigenetic regulatory enzymes in cancer treatment. Finally, we highlight how the natural compounds berberine and ginsenosides can target epigenetic regulatory enzymes to treat cancer.

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“…Antioxidants evaluated in the studies joined in this review comprised curcumin tablet (CWT) (Abuduaini, et al, 2021); 6benzylaminopurine, piperine (pip), chrysin (chr), kaempferol (kaem), scopoletin (sco), vitamin D3 (VitD3), (Heriniaina, et al, 2018); RY3-a, CY3-a-1, CY3-a-15, RY3-b, RY3-c (Zhong, et al, 2019); cold atmospheric plasma (CAP) (Zhai, et al, 2021); butin (Huo, et al, 2017;Lai, et al, 2021); caffeic acid and luteolin (Lai, et al, 2021), and galangin (Huo, et al, 2014). The results of all published works on these antioxidants suggest that at least one of the antioxidants investigated in each article is promising for treating vitiligo.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The studies included in this review used mice (n = 5) or zebrafish (n = 3) as the in vivo models, and one of the articles (Zhong, et al, 2019) used both these in vivo models. For articles that carried out in vitro investigation, the B16F10 cell line was used.…”

Section: Study Characteristicsmentioning

confidence: 99%

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Mechanisms of antioxidants in the treatment of vitiligo in vivo: a systematic review

Almeida

Lopez

Araújo

et al. 2022

RSD

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Vitiligo is characterized by skin discoloration in different body regions, and its prevalence in the world population can reach 1%. Its cause is still undefined but possibly related to biochemical, environmental, immunological, and genetic events. In addition, individuals with vitiligo present electrolyte disturbances in the melanocytes, and it has been one of the targets of studies for treating this pathology. This systematic review aimed to gather and evaluate in vivo studies that described the mechanism of action of antioxidants in vitiligo. PubMed, Web of Science, Embase, Science Direct, LILACS, Open Grey and Google Scholar were used as research sources. The search included all articles up to October 16, 2021, with no start date restrictions. The search yielded 390 articles, and 7 of these were selected according to the inclusion criteria. The compounds studied in the articles selected for this review were curcumin, Cold Atmospheric Plasma, butin, galangin, 2',3,4,4'-tetrahydrochalcone and its derivatives, 6-benzylaminopurine, piperine, chrysin, kaempferol, scopoletin, vitamin D3, caffeic acid, and luteolin. The results showed that the main mechanisms of action of antioxidants in the treatment of vitiligo are the increase in tyrosinase activity by increasing the synthesis of TYR and TRP-1, the positive regulation of the number of epidermal cells, the redox balance, activation and regulation of MITF, and malondialdehyde and cholinesterase/acetylcholinesterase content. Thus, these pathways can be considered targets for evaluating different antioxidant compounds to act in treating vitiligo.

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Natural product-based design, synthesis and biological evaluation of 2′,3,4,4′-tetrahydrochalcone analogues as antivitiligo agents

Cited by 6 publications

References 31 publications

Research Progress on Targeted Antioxidant Therapy and Vitiligo

Research Progress on Targeted Antioxidant Therapy and Vitiligo

Targeting Epigenetic Regulatory Enzymes for Cancer Therapeutics: Novel Small-Molecule Epidrug Development

Mechanisms of antioxidants in the treatment of vitiligo in vivo: a systematic review

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