Natural polysaccharides as targeting tools of drugs to the human colon

Local Prevention of Oxidative Stress in the Intestinal Epithelium of the Rat by Adhesive Liposomes of Superoxide Dismutase and Tempamine

“…The uniqueness of our hypothesis is the topical administration of the liposomal antioxidants to the mucosa of the injured epithelium. Supporting colonic delivery systems previously developed in our laboratory could be used for the local delivery of these liposomal borne remedies …”

Local Prevention of Oxidative Stress in the Intestinal Epithelium of the Rat by Adhesive Liposomes of Superoxide Dismutase and Tempamine

“…The uniqueness of our hypothesis is the topical administration of the liposomal antioxidants to the mucosa of the injured epithelium. Supporting colonic delivery systems previously developed in our laboratory could be used for the local delivery of these liposomal borne remedies …”

A pH‐sensitive nano drug delivery system derived from pullulan/doxorubicin conjugate

“…For the IR spectrum of carboxymethylated pullulan, the peak at 1735 cm 21 could be assigned to C¼ ¼O group of carboxymethylation and it indicated the embarking of carboxymethyl onto the pullulan. After the amidation of the carboxylic group, this peak shifted to 1636 cm 21 . When the DOX was bound to the AMP, the peak shifted to 1607 cm 21 , perhaps due to the attraction of the electrons by the conjugated DOX.…”

Advances in Oral Drug Delivery for Regional Targeting in the Gastrointestinal Tract - Influence of Physiological, Pathophysiological and Pharmaceutical Factors

“…The consistently high levels of resident bacteria in the colon have been exploited for colon-specific drug delivery and is considered a much more reliable factor (McConnell et al, 2008). Numerous enzymes are produced by the colonic bacterial flora, such as polysaccharidases, azoreductases, and glycosidases (Scheline, 1973;Cummings and Macfarlane, 1991;Rubinstein, 2000), and have been utilized in drug delivery approaches. For example, biodegradable polymers in coatings and/or matrix formulations have been used for regional drug targeting in the colon.…”

“…For example, biodegradable polymers in coatings and/or matrix formulations have been used for regional drug targeting in the colon. In particular, polysaccharide-based systems have shown promising results, with non-starch polysaccharides being commonly used (Hovgaard and Brondsted, 1996;Rubinstein, 2000;Shah et al, 2011). Non-starch polysaccharides are more resistant to digestion and absorption in the small intestine but are metabolized in the large intestine.…”

Local Prevention of Oxidative Stress in the Intestinal Epithelium of the Rat by Adhesive Liposomes of Superoxide Dismutase and Tempamine

“…The uniqueness of our hypothesis is the topical administration of the liposomal antioxidants to the mucosa of the injured epithelium. Supporting colonic delivery systems previously developed in our laboratory could be used for the local delivery of these liposomal borne remedies …”

A pH‐sensitive nano drug delivery system derived from pullulan/doxorubicin conjugate

“…For the IR spectrum of carboxymethylated pullulan, the peak at 1735 cm 21 could be assigned to C¼ ¼O group of carboxymethylation and it indicated the embarking of carboxymethyl onto the pullulan. After the amidation of the carboxylic group, this peak shifted to 1636 cm 21 . When the DOX was bound to the AMP, the peak shifted to 1607 cm 21 , perhaps due to the attraction of the electrons by the conjugated DOX.…”

Advances in Oral Drug Delivery for Regional Targeting in the Gastrointestinal Tract - Influence of Physiological, Pathophysiological and Pharmaceutical Factors

“…The consistently high levels of resident bacteria in the colon have been exploited for colon-specific drug delivery and is considered a much more reliable factor (McConnell et al, 2008). Numerous enzymes are produced by the colonic bacterial flora, such as polysaccharidases, azoreductases, and glycosidases (Scheline, 1973;Cummings and Macfarlane, 1991;Rubinstein, 2000), and have been utilized in drug delivery approaches. For example, biodegradable polymers in coatings and/or matrix formulations have been used for regional drug targeting in the colon.…”

“…For example, biodegradable polymers in coatings and/or matrix formulations have been used for regional drug targeting in the colon. In particular, polysaccharide-based systems have shown promising results, with non-starch polysaccharides being commonly used (Hovgaard and Brondsted, 1996;Rubinstein, 2000;Shah et al, 2011). Non-starch polysaccharides are more resistant to digestion and absorption in the small intestine but are metabolized in the large intestine.…”

Local Prevention of Oxidative Stress in the Intestinal Epithelium of the Rat by Adhesive Liposomes of Superoxide Dismutase and Tempamine

“…The uniqueness of our hypothesis is the topical administration of the liposomal antioxidants to the mucosa of the injured epithelium. Supporting colonic delivery systems previously developed in our laboratory could be used for the local delivery of these liposomal borne remedies …”

A pH‐sensitive nano drug delivery system derived from pullulan/doxorubicin conjugate

“…For the IR spectrum of carboxymethylated pullulan, the peak at 1735 cm 21 could be assigned to C¼ ¼O group of carboxymethylation and it indicated the embarking of carboxymethyl onto the pullulan. After the amidation of the carboxylic group, this peak shifted to 1636 cm 21 . When the DOX was bound to the AMP, the peak shifted to 1607 cm 21 , perhaps due to the attraction of the electrons by the conjugated DOX.…”

Advances in Oral Drug Delivery for Regional Targeting in the Gastrointestinal Tract - Influence of Physiological, Pathophysiological and Pharmaceutical Factors

“…The consistently high levels of resident bacteria in the colon have been exploited for colon-specific drug delivery and is considered a much more reliable factor (McConnell et al, 2008). Numerous enzymes are produced by the colonic bacterial flora, such as polysaccharidases, azoreductases, and glycosidases (Scheline, 1973;Cummings and Macfarlane, 1991;Rubinstein, 2000), and have been utilized in drug delivery approaches. For example, biodegradable polymers in coatings and/or matrix formulations have been used for regional drug targeting in the colon.…”

“…For example, biodegradable polymers in coatings and/or matrix formulations have been used for regional drug targeting in the colon. In particular, polysaccharide-based systems have shown promising results, with non-starch polysaccharides being commonly used (Hovgaard and Brondsted, 1996;Rubinstein, 2000;Shah et al, 2011). Non-starch polysaccharides are more resistant to digestion and absorption in the small intestine but are metabolized in the large intestine.…”