2011
DOI: 10.3892/mmr.2011.483
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Abstract. Tubeimoside I (TBMS I) is a natural compound extracted from Bolbostemma paniculatum (Maxim.) Franquet (Cucurbitaceae), a traditional Chinese herbal medicine widely used for the treatment of inflammation. Recently, it has been suggested that TBMS I may be a potent anticancer agent for a variety of human cancers. However, TBMS I is known to distribute preferentially in the liver, and thus may harm normal liver cells if it is delivered systemically for cancer treatment. This safety concern warrants care… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2014
2014
2022
2022

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 6 publications
(1 citation statement)
references
References 11 publications
0
1
0
Order By: Relevance
“…AMPK and mTOR signaling pathways are two main autophagy-initiating pathways 26 . Considering that TBM could damage the mitochondria and cause the depletion of mitochondrial transmembrane potential (∆Ψm) 27 , 28 , which subsequently decreased the production of energy in the form of adenosine triphosphate (ATP), we hypothesized that AMPK might play a critical role in TBM-induced autophagy. To confirm this, we firstly measured the ATP levels in HeLa and SiHa cells treated with TBM.…”
Section: Resultsmentioning
confidence: 99%
“…AMPK and mTOR signaling pathways are two main autophagy-initiating pathways 26 . Considering that TBM could damage the mitochondria and cause the depletion of mitochondrial transmembrane potential (∆Ψm) 27 , 28 , which subsequently decreased the production of energy in the form of adenosine triphosphate (ATP), we hypothesized that AMPK might play a critical role in TBM-induced autophagy. To confirm this, we firstly measured the ATP levels in HeLa and SiHa cells treated with TBM.…”
Section: Resultsmentioning
confidence: 99%