Natural material-decorated mesoporous silica nanoparticle container for multifunctional membrane-controlled targeted drug delivery

Hu, Yan; Ke, Lei; Chen, Hao; Ma, Zhuo; Yang, Xinzhou; Zhao, Dan; Su-ying, Zeng; Xiao, Xincai

doi:10.2147/ijn.s148438

Cited by 34 publications

(29 citation statements)

References 46 publications

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“…We can, therefore, determine that the %EE of our process is approximately 85%. This high yield is obtained thanks to the difference of solubility of MBT between the two phases and to an in situ encapsulation process, higher than the 45% to 60% that is expected for encapsulation of mesoporous silica particles with drugs or enzymes, for instance. In presence of hydroxide ions, the release is then quickly achieved with approximately 50% of the total MBT content released in the first 5 min, and a slower release for up to 2 hr.…”

Section: Resultsmentioning

confidence: 85%

Incorporation of silica nanocontainers and its impact on a waterborne polyurethane coating

Loison

Denis²,

Groult

et al. 2019

Materials & Corrosion

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In the present work, we describe the development and characterization of a versatile smart coating containing an encapsulated inhibitor. This includes the synthesis and characterization of hollow spherical nanocapsules with diameters ranging from 180 to 200 nm. These particles are able to release their payload when exposed to an alkaline environment, what could be induced by corrosionlinked processes. A corrosion inhibitor, namely 2-mercaptobenzothiazole has been encapsulated, after what the capsules were incorporated in a polyurethane (PU) matrix; optimization of the process led to homogeneous coatings with a good dispersion of silica assessed by micro-fluorescence spectroscopy. Electrochemical impedance spectroscopy highlighted a negative effect of the capsules' addition to the PU network, affecting the coating's barrier properties. However, the release of the inhibitor upon water ingress in the coating and potential short-term protection was seen. Nevertheless, tests conducted on coatings with artificial defects could not lead to a reduction of the corrosion rate, probably due to the large size of the defects. K E Y W O R D Scorrosion protection, electrochemical impedance spectroscopy, silica incorporation, smart coatings

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Section: Resultsmentioning

confidence: 85%

Incorporation of silica nanocontainers and its impact on a waterborne polyurethane coating

Loison

Denis²,

Groult

et al. 2019

Materials & Corrosion

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“…Regarding the drug delivery application, polymers are the most preferred innovative materials as the tendency to improve the fate and performance of any therapeutic molecule is high by changing their delivery pattern in addition to offering structural diversities and different functionalities. [ 40 ] Moreover, these polymers act as controlled delivery vehicles for several guest molecules by prolonging the drug effect by maintaining the levels in the therapeutic window. Considering these significant facts, enormous efforts have been put forward to fabricating the versatile surfaces of MSNs by coating with several polymers.…”

Section: Advanced Fabrication Of Msnsmentioning

confidence: 99%

Nanoarchitectured Structure and Surface Biofunctionality of Mesoporous Silica Nanoparticles

et al. 2020

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Mesoporous silica nanoparticles (MSNs), one of the important porous materials, have garnered interest owing to their highly attractive physicochemical features and advantageous morphological attributes. They are of particular importance for use in diverse fields including, but not limited to, adsorption, catalysis, and medicine. Despite their intrinsic stable siliceous frameworks, excellent mechanical strength, and optimal morphological attributes, pristine MSNs suffer from poor drug loading efficiency, as well as compatibility and degradability issues for therapeutic, diagnostic, and tissue engineering purposes. Collectively, the desirable and beneficial properties of MSNs have been harnessed by modifying the surface of the siliceous frameworks through incorporating supramolecular assemblies and various metal species, and through incorporating supramolecular assemblies and various metal species and their conjugates. Substantial advancements of these innovative colloidal inorganic nanocontainers drive researchers in promoting them toward innovative applications like stimuli (light/ultrasound/magnetic)‐responsive delivery‐associated therapies with exceptional performance in vivo. Here, a brief overview of the fabrication of siliceous frameworks, along with discussions on the significant advances in engineering of MSNs, is provided. The scope of the advancement in terms of structural and physicochemical attributes and their effects on biomedical applications with a particular focus on recent studies is emphasized. Finally, interesting perspectives are recapitulated, along with the scope toward clinical translation.

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“…MSN modification was adapted from literature [98,99] and was described previously by the authors [40]. Approximately, 200 mg of MSNs and 15 mg of chitosan (C) in 40 mL of acetic acid (10 % v/v), and stirred at ambient temperature over 24 h. The CMSNs were then centrifuged, washed with absolute ethanol and thereafter with deionized water, and dried at 60 • C for 24 h. For modification with polyethylene glycol (P) and chitosan (C), 22.5 mg of C and 179 mg or 449 mg of polyethylene glycol 2000 were added separately to dilute acetic acid (30 mL, 2%; pH 4.6), followed by the addition of 7.725 mg of TPP (15 mL in 18 MΩ water).…”

Section: Msn Modification With Chitosan and Polyethyleneglycolmentioning

confidence: 99%

Sterically Stabilised Polymeric Mesoporous Silica Nanoparticles Improve Doxorubicin Efficiency: Tailored Cancer Therapy

Moodley

Singh

2020

Molecules

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The fruition, commercialisation and clinical application combining nano-engineering, nanomedicine and material science for utilisation in drug delivery is becoming a reality. The successful integration of nanomaterial in nanotherapeutics requires their critical development to ensure physiological and biological compatibility. Mesoporous silica nanoparticles (MSNs) are attractive nanocarriers due to their biodegradable, biocompatible, and relative malleable porous frameworks that can be functionalized for enhanced targeting and delivery in a variety of disease models. The optimal formulation of an MSN with polyethylene glycol (2% and 5%) and chitosan was undertaken, to produce sterically stabilized, hydrophilic MSNs, capable of efficient loading and delivery of the hydrophobic anti-neoplastic drug, doxorubicin (DOX). The pH-sensitive release kinetics of DOX, together with the anticancer, apoptosis and cell-cycle activities of DOX-loaded MSNs in selected cancer cell lines were evaluated. MSNs of 36-60 nm in size, with a pore diameter of 9.8 nm, and a cumulative surface area of 710.36 m 2 /g were produced. The 2% pegylated MSN formulation (PCMSN) had the highest DOX loading capacity (0.98 mg dox /mg msn ), and a sustained release profile over 72 h. Pegylated-drug nanoconjugates were effective at a concentration range between 20-50 µg/mL, inducing apoptosis in cancer cells, and affirming their potential as effective drug delivery vehicles.Molecules 2020, 25, 742 2 of 22 MSNs possess a large active surface area which can be selectively polymerised or functionalised for stimuli-responsive purposes [11], tunable pore size and large pore volumes for the loading and controlled release of the cargo, and have shown favourable tolerance levels both in vitro and in vivo [12][13][14].MSNs are being extensively researched as theranostic devices for diseases, especially for cancer therapy [15]. Conventional cancer treatment options such as surgery, radiotherapy and chemotherapy [16], have not been fully effective, resulting in snowballing recurrence rates and depression in the quality of life [17,18]. Unpleasant side-effects are often linked to the anti-neoplastic drugs used, which act by inhibiting cellular mechanisms of DNA replication that are up-regulated in cancer cells. These cytostatic or cytotoxic compounds usually have low bioavailability and are thus administered at high dosages or for prolonged dosing intervals, leading to systemic side effects at non-specific sites [19,20].Doxorubicin (DOX) remains one of the most efficient anthracycline drugs available and is used in the treatment of diverse cancers, including breast, cervical, bone, gastric and leukaemia [21][22][23]. Despite its popularity, its low solubility [24][25][26], coupled with increased dosing frequencies [27][28][29] has resulted in many associated side effects, including cardiotoxicity [30][31][32], myelosuppression [33,34], induced vomiting with nausea [35,36], and alopecia [18,37]. Critical evaluation of these detrimental side-effects that become more...

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Natural material-decorated mesoporous silica nanoparticle container for multifunctional membrane-controlled targeted drug delivery

Cited by 34 publications

References 46 publications

Incorporation of silica nanocontainers and its impact on a waterborne polyurethane coating

Incorporation of silica nanocontainers and its impact on a waterborne polyurethane coating

Nanoarchitectured Structure and Surface Biofunctionality of Mesoporous Silica Nanoparticles

Sterically Stabilised Polymeric Mesoporous Silica Nanoparticles Improve Doxorubicin Efficiency: Tailored Cancer Therapy

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