Natural Killer/T‐cell Lymphomas

Kim, Seok Jin; Suzuki, Ritsuro; Jaccard, Arnaud; Lim, Soon Thye; Kim, Won Seog

doi:10.1002/9781119671336.ch12

Cited by 4 publications

(6 citation statements)

References 93 publications

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“…Photoacoustic imaging provides depth penetration of several centimeters, sub-millimeter spatial resolution, and less than a second temporal resolution. [20][21][22] Photoacoustic imaging is not sensitive toward implanted stem cells alone, but through the use of exogenous contrast agents such as gold nanoparticles, 9,18,[23][24][25] carbon nanotubes, [26][27][28] and Prussian blue nanoparticles, 29 stem cells have been visualized using this technique. Gold nanoparticles in particular have shown low toxicity and good loading into stem cells for long-term cell tracking.…”

mentioning

confidence: 99%

In Vivo Photoacoustic Tracking of Mesenchymal Stem Cell Viability

2019

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Adult stem cell therapy has demonstrated improved outcomes for treating cardiovascular diseases in preclinical trials. The development of imaging tools may increase our understanding of the mechanisms of stem cell therapy, and a variety of imaging tools have been developed to image transplanted stem cells in vivo; however, they lack the ability to interrogate stem cell function longitudinally. Here, we report the use of a nanoparticle-based contrast agent that can track stem cell viability using photoacoustic imaging. The contrast agent consists of inert gold nanorods coated with IR775c, a reactive oxygen species (ROS) sensitive near-infrared dye. Upon cell death, stem cells produce ROS to degrade the cell. Using this feature of stem cells, the viability can be measured by comparing the IR775c signal to the ROS insensitive gold nanorod signal, which can also be used to track stem cell location. The nanoprobe was successfully loaded into mesenchymal stem cells (MSCs), and then, MSCs were transplanted into the lower limb of a mouse and imaged using combined ultrasound and photoacoustic imaging. MSC viability was assessed using the nanoprobe and displayed significant cell death within 24 h and an estimated 5% viability after 10 days. This nanoparticle system allows for longitudinal tracking of MSC viability in vivo with high spatial and temporal resolution which other imaging modalities currently cannot achieve.

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mentioning

confidence: 99%

In Vivo Photoacoustic Tracking of Mesenchymal Stem Cell Viability

2019

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“…The other two members of this sub-group, Set3 and Set4, contain divergent SET domains which contain amino acid alterations that are likely to impede catalytic activity [64]. Indeed, to date, methyltransferase activity has not been detected for either protein, although each protein has been reported to interact with chromatin [32,50,65]. In addition, Set3 is in a complex with two histone deacetylases, Hos2 and Hst1, as well as other factors [50], and has a well-documented role in the regulation of gene expression [32,33].…”

Section: Budding Yeast Lysine Methyltransferasesmentioning

confidence: 99%

“…Indeed, to date, methyltransferase activity has not been detected for either protein, although each protein has been reported to interact with chromatin [32,50,65]. In addition, Set3 is in a complex with two histone deacetylases, Hos2 and Hst1, as well as other factors [50], and has a well-documented role in the regulation of gene expression [32,33].…”

Section: Budding Yeast Lysine Methyltransferasesmentioning

confidence: 99%

Using Yeast to Define the Regulatory Role of Protein Lysine Methylation

Jethmalani

Green

2020

CPPS

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: The post-translational modification (PTM) of proteins are crucial for cells to survive under diverse environmental conditions and to respond to stimuli. PTMS are known to govern a broad array of cellular processes including signal transduction and chromatin regulation. The PTM lysine methylation has been extensively studied within the context of chromatin and the epigenetic regulation of the genome. However, it has also emerged as a critical regulator of non-histone proteins important for signal transduction pathways. While the number of known non-histone protein methylation events is increasing, the molecular functions of many of these modifications are not yet known. Proteomic studies of the model system Saccharomyces cerevisiae suggest lysine methylation may regulate a diversity of pathways including transcription, RNA processing, translation, and signal transduction cascades. However, there has still been relatively little investigation of lysine methylation as a broad cellular regulator beyond chromatin and transcription. Here, we outline our current state of understanding of non-histone protein methylation in yeast and propose ways in which the yeast system can be leveraged to develop a much more complete picture of molecular mechanisms through which lysine methylation regulates cellular functions.

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“…SBA-16 es un sólido poroso con estructura cúbica y que se obtiene empleando medio ácido, tensoactivo Pluronic F127 y TEOS. Existen un método alterno de síntesis donde se combina Pluronic P123 con Pluronic F127 (EO106PO70EO106) o un sistema de butanol y Pluronic F127 [34][35]. SBA-16 generalmente tiene paredes de poros hasta de 6 nm, así que éstas poseen un mayor espesor que las del SBA-15.…”

Section: Sba-16unclassified

“…En este patrón de difracción se aprecian ligeras trazas (no etiquetadas) que se atribuyen a posibles estructuras no ordenadas. Sin embargo, primordialmente se observan los parámetros característicos de una estructura cubica Im3m, atribuida al pico de mayor intensidad, de acuerdo a los indices de Miller (110), requiriendose, además, la presencia de la señal ( 200) para respaldar lo anterior [3] y [78]. Como podemos observar, en el difractograma en cuestión, ambos indices de Miller fueron evidentes y por medio de sus respectivos angulos de las señales caracteristicas de difracción, se obtuvieron las distancias interplanares respectivas, empleando la ley de Bragg reportada aquí como Ecuación 2.6.1.…”

Section: Caracterización De Parámetros Texturales Y Morfológicos De Sba-16unclassified

Síntesis y propiedades texturales de algunos materiales mesoporosos modelo

Juárez

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Natural Killer/T‐cell Lymphomas

Cited by 4 publications

References 93 publications

In Vivo Photoacoustic Tracking of Mesenchymal Stem Cell Viability

In Vivo Photoacoustic Tracking of Mesenchymal Stem Cell Viability

Using Yeast to Define the Regulatory Role of Protein Lysine Methylation

Síntesis y propiedades texturales de algunos materiales mesoporosos modelo

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