Natural killer cells in patients with hematologic malignancies, solid tumors and in recipients of hematopoietic stem cell transplantation

Ka, Al-Anazi; Al-Jasser, Asma M.; Wk, Al-Anazi

doi:10.29328/journal.jsctt.1001017

Cited by 2 publications

(1 citation statement)

References 272 publications

(455 reference statements)

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“…Allogeneic or syngeneic NK cells are currently considered as effective agents to fight hematological tumors. The infusion of large numbers of expanded NK cells has been shown to be feasible and safe for enhancing their activity in preclinical studies and also in vivo for patients with different types of hematological tumors [ 13 , 14 , 15 ].…”

Section: Nk Cells In Cancer Pathogenesismentioning

confidence: 99%

The Biological Role and Therapeutic Potential of NK Cells in Hematological and Solid Tumors

Velichinskii

Streltsova

Erokhina

et al. 2021

IJMS

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NK cells are an attractive target for cancer immunotherapy due to their potent antitumor activity. The main advantage of using NK cells as cytotoxic effectors over T cells is a reduced risk of graft versus host disease. At present, several variants of NK-cell-based therapies are undergoing clinical trials and show considerable effectiveness for hematological tumors. In these types of cancers, the immune cells themselves often undergo malignant transformation, which determines the features of the disease. In contrast, the current use of NK cells as therapeutic agents for the treatment of solid tumors is much less promising. Most studies are at the stage of preclinical investigation, but few progress to clinical trials. Low efficiency of NK cell migration and functional activity in the tumor environment are currently considered the major barriers to NK cell anti-tumor therapies. Various therapeutic combinations, genetic engineering methods, alternative sources for obtaining NK cells, and other techniques are aiming at the development of promising NK cell anticancer therapies, regardless of tumorigenesis. In this review, we compare the role of NK cells in the pathogenesis of hematological and solid tumors and discuss current prospects of NK-cell-based therapy for hematological and solid tumors.

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Section: Nk Cells In Cancer Pathogenesismentioning

confidence: 99%

The Biological Role and Therapeutic Potential of NK Cells in Hematological and Solid Tumors

Velichinskii

Streltsova

Erokhina

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

Neutrophils, NETs, NETosis and their paradoxical roles in COVID-19

Ka¹,

Wk²,

Al-Jasser³

2020

J Stem Cell Ther Transplant

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The pandemic of COVID-19 has adversely aff ected the world in many aspects. The health and economic sectors suff er most of the repercussions of this disease. The search for a cure for this rapidly spreading virus which is causing massive life losses worldwide requires clear understanding of the immunopathogenesis of this virus so as to develop pinpointed targeted therapies rather than relying mainly on supportive care measures and drug repurposing to fi ght this life-threatening virus infection.Neutrophils, neutrophil extracellular traps (NETs), and NETosis are not well studied not only in COVID-19, but also in coroviruses in general. The review will shed lights on the functions of neutrophils, NETs, and NETosis in various infectious complications as well as in sepsis and acute lung conditions in an attempt to understand their actual roles and in order to help in designing targeted therapies in the near future.

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Natural killer cells in patients with hematologic malignancies, solid tumors and in recipients of hematopoietic stem cell transplantation

Abstract: How to cite this article: Al-Anazi KA, Al-Jasser AM, Al-Anazi WK. Natural killer cells in patients with hematologic malignancies, solid tumors and in recipients of hematopoietic stem cell transplantation.

Cited by 2 publications

References 272 publications

The Biological Role and Therapeutic Potential of NK Cells in Hematological and Solid Tumors

The Biological Role and Therapeutic Potential of NK Cells in Hematological and Solid Tumors

Neutrophils, NETs, NETosis and their paradoxical roles in COVID-19

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