Natural history of psoriasis in 61 twin pairs

Farber, Eugene M.

doi:10.1001/archderm.109.2.207

Cited by 94 publications

(68 citation statements)

References 2 publications

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“…The illness develops in as many as half of the siblings of persons with psoriasis when both parents are affected, but prevalence falls to 16% when only one parent has psoriasis and to 8% when neither parent is affected (Watson et al, 1972). The concordance rate for monozygotic twins is around 70%, as compared with some 20% for dizygotic twins, which further supports the concept of genetic predisposition (Farber et al, 1974;Brandrup et al, 1982). Within the past decade, a number of psoriasis susceptibility loci have been mapped using linkage methods.…”

Section: Introductionmentioning

confidence: 65%

Association between HLA-Cw*0602 polymorphism and psoriasis risk: a meta-analysis

Wu¹,

Wu²,

Liu³

et al. 2011

Genet. Mol. Res.

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ABSTRACT. Numerous studies have evaluated the association between human leukocyte antigen (HLA) Cw*0602 polymorphism and psoriasis risk. However, the results have been inconsistent. We made a metaanalysis of the association between HLA-Cw*0602 polymorphism and psoriasis risk. Eighteen studies were retrieved, reporting a total of 3419 psoriasis patients and 3297 healthy controls. The associations between HLA-Cw*0602 polymorphism and psoriasis risk were estimated by pooled odds ratio (OR) and 95% confidence interval (95%CI). We found significant associations between HLA-Cw*0602 polymorphism and psoriasis risk in the comparisons of positive versus negative alleles (OR = 4.55, 95%CI = 3.65-5.67, P < 0.00001); positive homozygote versus negative homozygote combined with heterozygote (OR = 14.00, 95%CI = 8.47-23.15, P < 0.00001); positive homozygote combined with heterozygote versus negative homozygote (OR = 5.11, 95%CI = 3.86-6.76, P < 0.00001); positive homozygote versus negative homozygote (OR = 23.03, 95%CI = 13.95-38.00, P < 0.00001), and positive homozygote versus heterozygote (OR = 4.21, 95%CI = 2.35-7.00, P < 0.00001). In conclusion, the positive allele of HLA-Cw*0602 polymorphism appears to be a risk factor for psoriasis.

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Section: Introductionmentioning

confidence: 65%

Association between HLA-Cw*0602 polymorphism and psoriasis risk: a meta-analysis

Wu¹,

Wu²,

Liu³

et al. 2011

Genet. Mol. Res.

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“…Farber and colleagues (30) first demonstrated this with the finding that among 61 pairs of twins, the risk of psoriasis was 2-3 times higher in monozygotic siblings, compared with dizygotic siblings. At least, nine chromosomal loci with a significant linkage to disease development have since been identified and have been named psoriasis susceptibility (PSORS) 1-9 (31).…”

Section: The Pathophysiology Of Psoriasismentioning

confidence: 97%

Early intervention in psoriasis and immune-mediated inflammatory diseases: A hypothesis paper

Girolomoni

Griffiths

Krueger

et al. 2014

Journal of Dermatological Treatment

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Psoriasis is an immune-mediated inflammatory disease (IMID) which may have a major impact on a patient's life, especially when the disease is moderate to severe. There is evidence that treatment of psoriasis during the first years is conservative and frequently based on topical agents which rarely clear lesions. Treatment with systemic agents including biologics is often undertaken only when topical agents have proved unsuitable, even in patients with moderate to severe disease. However, there is evidence that in other IMIDs (rheumatoid arthritis and Crohn's disease), targeted systemic treatment given early in the treatment pathway may improve long-term patient outcomes. We hypothesize that a patient-centered therapeutic approach, undertaken early in the psoriasis treatment pathway (''early intervention'') with the goal of complete clearance, may improve control of cutaneous symptoms and may also modify disease course and burden. Critical points to address when designing an early intervention study would include: the definition of psoriasis disease activity; patient selection; intervention selection; and dosing strategies.

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“…Several family-based studies have shown marked increases in psoriasis risk as relatedness increases; most notably psoriasis risk rises from 20% in dizygotic twins to 70% in monozygotic twins. 5 For decades both association and linkage results have pointed to a strong predisposing effect from the MHC region, and recent association-based evidence has highlighted HLA-Cw*0602 as a likely primary candidate responsible for this effect. 6 Broadly speaking, the smaller susceptibility effects of non-MHC loci have taken longer to identify at high resolution.…”

Section: Introductionmentioning

confidence: 99%

Detailed genetic characterization of the interleukin-23 receptor in psoriasis

García¹,

Chang²,

Brandon³

et al. 2008

Genes Immun

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Using a multi-tiered, case-control association design, scanning 25 215 gene-centric SNPs, we previously identified two psoriasis susceptibility genes: IL12B and IL23R. These results have recently been confirmed. To better characterize the IL23R psoriasis-association, we used a fine mapping strategy to identify 59 additional IL23R-linked SNPs, which were genotyped in our three independent, white North American sample sets (42800 individuals in toto). A sliding window of haplotype association demonstrates colocalization of psoriasis susceptibility effects within the boundaries of IL23R across all sample sets, thereby decreasing the likelihood that neighboring genes, particularly IL12RB2, are driving the association at this region. Additional haplotype work identified two 5-SNP haplotypes with strong protective effects, consistent across our three sample sets (OR common ¼ 0.67; P comb ¼ 4.32E-07). Importantly, heterogeneity of effect was extremely low between sample sets for these haplotypes (P Het ¼ 0.961). Together, these protective haplotypes attain a frequency of 16% in controls, declining to 11% in cases. The characterization of association patterns within IL23R to specific predisposing/protective variants will play an important role in the elucidation of psoriasis etiology and other related phenotypes. Further, this work is essential to lay the foundation for the role of IL23R genetics in response to pharmaceutical therapy and dosage.

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Natural history of psoriasis in 61 twin pairs

Cited by 94 publications

References 2 publications

Association between HLA-Cw*0602 polymorphism and psoriasis risk: a meta-analysis

Association between HLA-Cw*0602 polymorphism and psoriasis risk: a meta-analysis

Early intervention in psoriasis and immune-mediated inflammatory diseases: A hypothesis paper

Detailed genetic characterization of the interleukin-23 receptor in psoriasis

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