Natural history of decompensated hepatitis C virus-related cirrhosis. A study of 200 patients

HIV coinfection shortens the survival of patients with hepatitis C virus-related decompensated cirrhosis

“…HE as the first decompensation has also been found previously to have a strong impact on the survival of patients with cirrhosis, 29,30 including those harboring HCV-related cirrhosis. 25 In our study, HE was associated with a poorer outcome independently of the number of simultaneous events patients presented. Moreover, only 4 of 115 (4%) patients with HE as the first hepatic decompensation showed PHGB simultaneously (data not shown).…”

“…In other studies in which the survival of decompensated cirrhosis was assessed, HCC was not in- cluded as a type of decompensation. 25,26 This fact might have led to a reduction in the survival of the patients included in this survey. However, the survival of HIVuninfected patients in this study at 5 years was 44%, a figure close to the 51% reported by Planas et al 25 and the 50% found in the EUROHEP cohort.…”

“…25,26 This fact might have led to a reduction in the survival of the patients included in this survey. However, the survival of HIVuninfected patients in this study at 5 years was 44%, a figure close to the 51% reported by Planas et al 25 and the 50% found in the EUROHEP cohort. 26 Moreover, the presence of HCC did not predict survival-although if HCC had affected mortality, the differences between HIV-infected and HIV-uninfected patients would have been even larger after adjusting for HCC, because it was much more frequent in the latter group.…”

“…These parameters, as well as age, have been found to be prognostic variables in decompensated HCVrelated cirrhosis in patients without HIV infection. [25][26][27] HDV coinfection is associated with a poorer prognosis in decompensated cirrhosis in patients infected with hepatitis B virus. 28 Likewise, hepatitis B virus infection has been proven to be associated with a higher risk of ESLD in HCV-infected patients in other studies.…”

Association of celiac disease and portal hypertension: Cirrhotic or noncirrhotic

“…In this series, the mean age of patients was 28.8 years. Duration of symptoms of cirrhosis was relatively longer (83.7 months) as compared to natural history of cirrhosis and 12 % patients presented with splenomegaly [4]. Eighty percent had cryptogenic cirrhosis (CC) and most of the symptoms of CLD improved significantly on gluten-free diet (GFD).…”