Natural antioxidants enhance the power of physical and mental activities versus risk factors inducing progression of Alzheimer's disease in rats

Ali, Azza A.; El-Fattah, Abeer I. Abd; Abu-Elfotuh, Karema; Elariny, Hemat A.

doi:10.1016/j.intimp.2021.107729

Cited by 19 publications

(14 citation statements)

References 80 publications

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“…Vitamins are essential elements in maintaining the physiological functions of the brain. Its antioxidant function, which can reduce oxidative stress in dementia pathology (Tadokoro et al, 2020 ; Ali et al, 2021 ), can also react with free radicals, thereby preventing hippocampal neuronal apoptosis caused by reperfusion after ischemia and playing a role in protecting the brain (Tagami et al, 1999 ). Vitamin E has been found in animal studies to reduce the harmful effects of -amyloid and improve cognitive function in rodents (Rota et al, 2005 ; Montiel et al, 2006 ).…”

Section: Discussionmentioning

confidence: 99%

Association of vitamin E intake in diet and supplements with risk of dementia: A meta-analysis

Zhao

Han

Zhang

et al. 2022

Front. Aging Neurosci.

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BackgroundDementia is a chronic progressive neurodegenerative disease that can lead to disability and death in humans, but there is still no effective prevention and treatment. Due to the neuroprotective effects of vitamin E, a large number of researchers have explored whether vitamin E can reduce the risk of dementia. Some researchers believe that vitamin E can reduce the risk of dementia, while others hold the opposite conclusion. We therefore performed a meta-analysis to clarify the relationship between them.MethodsWe searched PubMed, Embase, and Web of Science databases for articles on the connection of dietary and supplementation vitamin E with dementia risk from inception through April 2022 using the main keywords “dementia,” “Alzheimer's disease,” “vitamin E,” and “tocopherol,” and used a random-utility model for pooled effect sizes. Odds ratios (OR) and 95% confidence intervals were derived using lower and higher doses as contrasts. Obtained data were shown and assessed using Stata12.0 free software.ResultsWe included 15 articles in sum. Among them, there were nine articles containing AD. By comparing the highest intake with the lowest intake, Combined ORs for high intake were as follows: dementia (OR = 0.79, 95% CI 0.70–0.88 I2 = 35.0%), Alzheimer's disease (OR = 0.78, 95% CI 0.64–0.94 I2 = 36.9%). Subgroup analyses were also performed by study type, diet and supplementation, and NOS score.ConclusionsHigh vitamin E intake from diet and supplements significantly reduces the risk of dementia and Alzheimer's disease.

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Section: Discussionmentioning

confidence: 99%

Association of vitamin E intake in diet and supplements with risk of dementia: A meta-analysis

Zhao

Han

Zhang

et al. 2022

Front. Aging Neurosci.

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“…Regarding nutritional interventions, more and more evidence arises that combined dietary components show synergistic beneficial actions with respect to AD pathology [ 255 , 256 ]. Multidomain interventions that target preventive, or early stage disease show potential for delaying the onset of dementia [ 259 , 378 , 389 , 390 ]. Dietary modifications combined with aerobic physical activity also led to cognitive improvements in participants with elevated blood pressure [ 413 ].…”

Section: Discussionmentioning

confidence: 99%

“…They reported significant reductions in the decline in cognition, memory, brain atrophy and AD progression. In summary, these findings indicate that the duration of the intervention as well as their starting point regarding the disease stage are crucial for their success [ 259 ].…”

Section: Individual Approachesmentioning

confidence: 99%

Interdisciplinary Approaches to Deal with Alzheimer’s Disease—From Bench to Bedside: What Feasible Options Do Already Exist Today?

Ablinger¹,

Dressel

Rott³

et al. 2022

Biomedicines

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Alzheimer’s disease is one of the most common neurodegenerative diseases in the western population. The incidence of this disease increases with age. Rising life expectancy and the resulting increase in the ratio of elderly in the population are likely to exacerbate socioeconomic problems. Alzheimer’s disease is a multifactorial disease. In addition to amyloidogenic processing leading to plaques, and tau pathology, but also other molecular causes such as oxidative stress or inflammation play a crucial role. We summarize the molecular mechanisms leading to Alzheimer’s disease and which potential interventions are known to interfere with these mechanisms, focusing on nutritional approaches and physical activity but also the beneficial effects of cognition-oriented treatments with a focus on language and communication. Interestingly, recent findings also suggest a causal link between oral conditions, such as periodontitis or edentulism, and Alzheimer’s disease, raising the question of whether dental intervention in Alzheimer’s patients can be beneficial as well. Unfortunately, all previous single-domain interventions have been shown to have limited benefit to patients. However, the latest studies indicate that combining these efforts into multidomain approaches may have increased preventive or therapeutic potential. Therefore, as another emphasis in this review, we provide an overview of current literature dealing with studies combining the above-mentioned approaches and discuss potential advantages compared to monotherapies. Considering current literature and intervention options, we also propose a multidomain interdisciplinary approach for the treatment of Alzheimer’s disease patients that synergistically links the individual approaches. In conclusion, this review highlights the need to combine different approaches in an interdisciplinary manner, to address the future challenges of Alzheimer’s disease.

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“…Cognitive dysfunction is the main expression of AD. d -galactose- and aluminum chloride-induced dementia model, a reliable animal model that resembles human dementia, has been widely used to screen anti-AD agents. , Aluminum chloride could induce neuronal inflammation and Aβ deposition in mice, resulting in learning and memory impairment. , In this study, we used an AD animal model induced with d -galactose and aluminum chloride to explore the effects of GB on AD. Recent studies have indicated that GB could ameliorate the learning and memory ability of vascular dementia rats .…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Ginkgolide B against Cognitive Impairment in Mice via Regulation of Gut Microbiota

Liu

Tao

Zhang

et al. 2021

J. Agric. Food Chem.

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Ginkgolide B (GB) is one of the main bioactive components of Ginkgo biloba leaf extracts with neuroprotective activity. However, the neuroprotective mechanism link between the anti-Alzheimer's disease (AD) efficiency of GB and gut microbiota have remained elusive. Here, we elucidated the effect and possible mechanism of GB against cognitive impairment in mice. Male mice were induced with D-galactose and aluminum chloride to establish an AD animal model, and then intragastrically treated with GB. Cognitive function was assessed by an object recognition test and an open-field test. Amyloid deposition and neuropathological change were detected. The levels of receptor for advanced glycation end products (RAGE), Bcl-2, and Bax were detected. Moreover, microbial compositions were measured by 16s rRNA sequencing. Our results showed that GB significantly alleviated cognitive dysfunction, neurodegeneration, and neuropathological changes in AD model mice. Moreover, GB treatment remarkably reduced the levels of RAGE and Bax and increased the level of Bcl-2 in AD model mice. GB treatment reversed the decreased abundance of Lactobacillus and the increased abundance of Bacteroidales, Muribaculaceae, and Alloprevotella, which led to reconstruction of gut microbiota. These findings demonstrated the neuroprotective effects of GB in AD mice, which were partly mediated by modulating gut dysbiosis, indicating that GB might be a potentially active supplement to alleviate AD.

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Natural antioxidants enhance the power of physical and mental activities versus risk factors inducing progression of Alzheimer's disease in rats

Cited by 19 publications

References 80 publications

Association of vitamin E intake in diet and supplements with risk of dementia: A meta-analysis

Association of vitamin E intake in diet and supplements with risk of dementia: A meta-analysis

Interdisciplinary Approaches to Deal with Alzheimer’s Disease—From Bench to Bedside: What Feasible Options Do Already Exist Today?

Protective Effect of Ginkgolide B against Cognitive Impairment in Mice via Regulation of Gut Microbiota

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