Natural and Synthetic Coumarins with Effects on Inflammation

Kirsch, Gilbert; Abdelwahab, Ahmed B.; Chaimbault, Patrick

doi:10.3390/molecules21101322

Cited by 107 publications

(88 citation statements)

References 50 publications

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“…Thus, the use of antioxidant drugs as a scavenger of free radicals may reduce the extent of myocardial damage [34]. Recently, several coumarins based [14,35,36]. Hence, our study investigated the effects of precotreatment with (E)-N ′ -(1-(7hydroxy-2-oxo-2H-chromen-3-yl) ethylidene) benzohydrazide, a potent synthesized hydrazone coumarin, on the changes in oxidative parameters and cardiac biomarkers levels, myocardial proapoptotic and antiapoptotic factors, and the modification on histopathological parameters and heart function, during ISO-induced MI in rats.…”

Section: Discussionmentioning

confidence: 99%

“…Coumarins are found in several plant families and essential oils and are used as fragrant additives in food and cosmetics [12]. Many reports have suggested that the coumarins possess a huge array of biological roles, such as antithrombotic, neuroprotective, antidiabetic, anticoagulant, anti-inflammatory, antioxidant, and antiplasmodial activities [13][14][15][16][17][18][19]. Due to technical advancement, the coumarins and its derivatives are becoming a potential source for new drug discovery [20].…”

Section: Introductionmentioning

confidence: 99%

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(E)-N′-(1-(7-Hydroxy-2-Oxo-2H-Chromen-3-Yl) Ethylidene) Benzohydrazide, a Novel Synthesized Coumarin, Ameliorates Isoproterenol-Induced Myocardial Infarction in Rats through Attenuating Oxidative Stress, Inflammation, and Apoptosis

Feriani

Khdhiri

Tir

et al. 2020

Oxidative Medicine and Cellular Longevity

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The present study was directed to investigate the effect of precotreatment with (E)-N′-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl) ethylidene) benzohydrazide (7-hyd.HC), a novel potent synthesized coumarin, on isoproterenol- (ISO-) induced myocardial infarction (MI) in rats. The hydrazone compound was characterized by IR, 1D, and 2D NMR analyses. Experimental induction of MI in rats was established by ISO (85 mg/kg/day, s.c) for two consecutive days (6th and 7th days). 7-hyd.HC or sintrom was given for 7 days prior and simultaneous to ISO injection. 7-hyd.HC offered a cardiopreventive effect by preventing heart injury marker leakage (LDH, ALT, AST, CK-MB, and cTn-I) from cardiomyocytes and normalizing cardiac function and ECG pattern, as well as improving lipid profile (TC, TG, LDL-C, and HDL-C), which were altered by ISO administration. Moreover, 7-hyd.HC precotreatment significantly mitigated the oxidative stress biomarkers, as evidenced by the decrease of lipid peroxidation and the increased level of the myocardial GSH level together with the SOD, GSH-Px, and catalase activities. 7-hyd.HC inhibited the cardiac apoptosis by upregulating the expression of Bcl-2 and downregulating the expression of Bax and caspase-3 genes. In addition, 7-hyd.HC reduced the elevated fibrinogen rate and better prevented the myocardial necrosis and improved the interstitial edema and neutrophil infiltration than sintrom. Overall, 7-hyd.HC ameliorated the severity of ISO-induced myocardial infarction through improving the oxidative status, attenuating apoptosis, and reducing fibrinogen production. The 7-hyd.HC actions could be mediated by its antioxidant, antiapoptotic, and anti-inflammatory capacities.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

(E)-N′-(1-(7-Hydroxy-2-Oxo-2H-Chromen-3-Yl) Ethylidene) Benzohydrazide, a Novel Synthesized Coumarin, Ameliorates Isoproterenol-Induced Myocardial Infarction in Rats through Attenuating Oxidative Stress, Inflammation, and Apoptosis

Feriani

Khdhiri

Tir

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…[9] Moreover, various coumarin-related derivatives serve as inhibitors of the lipoxygenase and cyclooxygenase pathways of arachidonate metabolism. [10,11] Given its favorable antiinflammatory activity, a coumarin framework has been used for chemical modification for identifying novel derivatives with improved pharmacological or pharmacokinetic profiles.…”

Section: Introductionmentioning

confidence: 99%

Anti‐Inflammatory Effect of Novel 7‐Substituted Coumarin Derivatives through Inhibition of NF‐κB Signaling Pathway

2019

Chemistry & Biodiversity

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A series of novel 7‐substituted coumarin derivatives were synthesized and evaluated. Biological screening results obtained by the evaluation of the compounds’ inhibition against LPS‐induced IL‐6 and TNF‐α release in RAW 264.7 cells indicated that most compounds exhibited potent anti‐inflammatory activity. Among them, N‐(3‐methoxybenzyl)‐2‐[(2‐oxo‐2H‐chromen‐7‐yl)oxy]acetamide (2d) showed the best activity. The potential targets of title compound 2d were reversely screened with the molecular modeling software, Discovery Studio 2017 R2. Screening and molecule docking results showed that 2d could bind to the active site (NLS Polypeptide) of NF‐κB p65, and this binding affinity was confirmed by surface plasmon resonance (SPR) analysis. Furthermore, Western blot assay showed that 2d remarkably blocked the NF‐κB signaling pathway in vitro. Collectively, all these findings suggested that compound 2d might be a promising lead compound worthy of further pursuit.

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“…In other studies, extracts used externally have been shown to reduce skin inflammation and edema (Kwon et al, 2011). Derivatives such as esculetin, fraxetin and daphnetin exhibit antioxidant activity, acting as inhibitors of the lipoxygenase and cyclooxygenase enzyme pathways (Kirsch et al, 2016). In vitro studies on coumarin compounds have served to demonstrate their antimicrobial and antifungal activity.…”

Section: Introductionmentioning

confidence: 99%

Coumarins as potential supportive medication for the treatment of epilepsy

Bryda¹,

Zagaja²,

Szewczyk³

et al. 2019

Acta Neurobiologiae Experimentalis

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Epilepsy, one of the most common neurological disorders, is a chronic disease of the brain manifested by seizures due to sudden, spontaneous bioelectrical discharges in nerve cells. An estimated 50 million people worldwide suffer from epilepsy.Antiepileptic drugs are the mainstream treatment for epilepsy; however, the drug resistance occurring in 20-30% of patients and side effects of available medications have resulted in a search for natural remedies that can support disease therapy. Coumarins may be a promising option. They are a group of natural plant-derived substances of great interest due to their broad spectrum of biological activities, including potent pharmacological properties. Recent data from experimental models demonstrates the possibility for coumarin use as a supporting treatment of epileptic seizures. This article focuses on the most recent research reports available in the literature relating to the use of several selected coumarins in different experimental models of epilepsy.

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Natural and Synthetic Coumarins with Effects on Inflammation

Cited by 107 publications

References 50 publications

(E)-N′-(1-(7-Hydroxy-2-Oxo-2H-Chromen-3-Yl) Ethylidene) Benzohydrazide, a Novel Synthesized Coumarin, Ameliorates Isoproterenol-Induced Myocardial Infarction in Rats through Attenuating Oxidative Stress, Inflammation, and Apoptosis

(E)-N′-(1-(7-Hydroxy-2-Oxo-2H-Chromen-3-Yl) Ethylidene) Benzohydrazide, a Novel Synthesized Coumarin, Ameliorates Isoproterenol-Induced Myocardial Infarction in Rats through Attenuating Oxidative Stress, Inflammation, and Apoptosis

Anti‐Inflammatory Effect of Novel 7‐Substituted Coumarin Derivatives through Inhibition of NF‐κB Signaling Pathway

Coumarins as potential supportive medication for the treatment of epilepsy

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