Nationwide survey of the prevalence of wheeze, rhino-conjunctivitis, and eczema among Japanese children in 2015

Morikawa, Emi; Sasaki, Mari; Yoshida, Koichi; Adachi, Yuichi; Odajima, Hiroshi; Akasawa, Akira

doi:10.1016/j.alit.2019.08.010

Cited by 33 publications

(29 citation statements)

References 26 publications

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“…Allergic conjunctivitis (AC) is an inflammatory disorder of conjunctivae which negatively affects the family and daily activities and is responsible for significant work and school absenteeism [1,2]. e prevalence can vary in intensity, seasonality, gender, country, and region [3][4][5][6]. However, the consensus is that a number of researchers have reported that the incidence of allergic diseases, including various types of allergic conjunctivitis, has increased significantly [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis

Meng

Shi

Zhang

et al. 2020

Journal of Ophthalmology

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Allergic conjunctivitis (AC) is a common allergic disease that is often associated with the onset of rhinitis or asthma. The incidence of AC has increased significantly in recent years possibly due to air pollution and climate warming. AC seriously affects patients’ quality of life and work efficiency. Th (T-helper) 2 immune responses and type I hypersensitivity reactions are generally considered the basis of occurrence of AC. It has been found that new subpopulations of T-helper cells, Th17 cells that produce interleukin-17 (IL-17), play an important role in the Th2-mediated pathogenesis of conjunctivitis. Studies have shown that Th17 cells are involved in a variety of immune inflammation, including psoriasis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, and asthma. However, the role of Th17 and IL-17 in AC is unclear. This paper will focus on how T-helper 17 cells and interleukin-17 are activated in the Th2 immune response of allergic conjunctivitis and how they promote the Th2 immune response of AC.

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Section: Introductionmentioning

confidence: 99%

The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis

Meng

Shi

Zhang

et al. 2020

Journal of Ophthalmology

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“…Many children suffer from allergic diseases that affect their quality of life. In Japan, the national prevalence of asthma and atopic dermatitis has been found to be approximately 10% [ 1 ]. Adult patients who suffer from allergic diseases often experience an economic burden [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of infantile wheezing and eczema in a metropolitan city in Japan: A complete census survey

et al. 2022

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Infantile wheezing and eczema are associated with the subsequent onset of asthma and other atopic diseases. However, there are no large population-based surveys on infantile allergic symptoms in Japan. The objective of the study was to determine the prevalence of wheezing and asthma in infants in Nagoya, Japan. This population-based cross-sectional study was performed in the metropolitan city of Nagoya, Japan. We surveyed parents to ascertain the prevalence of wheezing and eczema in infants who attended group health checkups at 3, 18, and 36 months of age. Their parents completed modified questionnaires from the International Study of Asthma and Allergies in Childhood. More than 90% of the approximately 40,000 children in each study group living in the target area were included in the survey. The prevalence of wheezing was 8%, 17%, and 13% at 3, 18, and 36 months, respectively, and was characterized by birth season. The prevalence of eczema was 24%, 30%, and 31%, at 3, 18, and 36 months, respectively. Participants born in autumn and winter had a higher incidence of eczema in each age group. Three-quarters of the children had a parental history of allergic conditions. Parental allergic diseases and male gender are risk factors for wheezing and eczema in children. This survey had a high response rate and covered almost the entire population of the target age groups in a large city. We believe that the results of this study, therefore, provide a much higher level of confidence regarding the prevalence of allergies in infants in Japan than that in previous studies with limited cohorts.

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“…Furthermore, childhood factors such as smoking environment and childhood viral infections that are reported to have associations with the incidence of childhood asthma [14][15][16] have not been evaluated. Because asthma is common during childhood, with approximately 10% prevalence in Japan, 17,18 parents are concerned about the association between prenatal and postnatal factors and the incidence of childhood asthma; therefore, the association of MRA with childhood asthma should be clarified.…”

Section: Introductionmentioning

confidence: 99%

Association between maternal ritodrine hydrochloride administration during pregnancy and childhood wheezing up to three years of age: The Japan environment and children's study

Murata

Kyozuka

Yasuda

et al. 2021

Pediatric Allergy Immunology

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Background:The effects of maternal ritodrine hydrochloride administration (MRA) during pregnancy on fetuses and offspring are not entirely clear. The present study aimed to evaluate the association between MRA and childhood wheezing using data from a nationwide Japanese birth cohort study.Methods: This study analyzed the data of the participants enrolled in the Japan Environment and Children's Study, a nationwide prospective birth cohort study, between 2011 and 2014. Data of women with singleton live births after 22 weeks of gestation were analyzed. The participants were divided according to MRA status.Considering childhood factors affecting the incidence of wheezing, including smoking environment and childhood viral infections, a logistic regression model was used to calculate odds ratios for "wheezing ever," diagnosis of asthma in the last 12 months, and "asthma ever" in women with MRA, with women who did not receive MRA as the reference. Additionally, participants were stratified by term births, and odds ratios for outcomes were calculated using a logistic regression model.

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Nationwide survey of the prevalence of wheeze, rhino-conjunctivitis, and eczema among Japanese children in 2015

Cited by 33 publications

References 26 publications

The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis

The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis

Prevalence of infantile wheezing and eczema in a metropolitan city in Japan: A complete census survey

Association between maternal ritodrine hydrochloride administration during pregnancy and childhood wheezing up to three years of age: The Japan environment and children's study

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