1973
DOI: 10.1038/icb.1973.2
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Abstract: Summary Trigeminal afferents in the nasopharynx of unanaesthetized rabbits detect substances in the inspired air potentially damaging to the respiratory tree, and initiate reflex apnoea in expiration, bradycardia, a rise in mean arterial pressure and widespread reduction in blood flow and peripheral conductance. The apnoea is due to direct suppression of respiratory neurones by trigeminal activity activity maninly in bulbospinal regions, and the cardiovascular changes to direct trigeminal effects, to trigminal… Show more

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Cited by 74 publications
(28 citation statements)
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“…Similarly, Nakamura and Hayashida (45) demonstrated that bradycardia evoked by smoke inhalation was completely abolished by either pentobarbital or chloralose, whereas White and McRitchie (69) showed that pentobarbital attenuated this reflex substantially. There are, to our knowledge, no studies comparing the effects of anesthetics on capsaicin-or AITC-evoked cardiovascular reflexes.…”
Section: Discussionmentioning
confidence: 99%
“…Similarly, Nakamura and Hayashida (45) demonstrated that bradycardia evoked by smoke inhalation was completely abolished by either pentobarbital or chloralose, whereas White and McRitchie (69) showed that pentobarbital attenuated this reflex substantially. There are, to our knowledge, no studies comparing the effects of anesthetics on capsaicin-or AITC-evoked cardiovascular reflexes.…”
Section: Discussionmentioning
confidence: 99%
“…The agent seems to cause a "catch" in the inhalation even before the agent can reach the lungs. Various experiments have implicated the trigeminal nerve in irritant-induced disruption of breathing [4,6,31]. This nerve also mediates the sensations of pungency triggered by irritants [11].…”
Section: Introductionmentioning
confidence: 99%
“…For example, in Figure 2 (25) one cannot determine the extent to which the hypertension and tachycardia are influenced by the respiratory changes, cough, and tachycardia, or are primary reflex actions. The hypertensions seen in anesthetized cats with mechanical stimulation of the respiratory tract from nose to trachea are much larger in spontaneously breathing animals than in those paralyzed and artificially ventilated (23). The whole-body mechanisms are very complex.…”
Section: Sensitization Inhibition and Interactionsmentioning
confidence: 99%
“…Since Kratschmer's work, an extensive literature has documented that irritants inhaled into the upper respiratory tract cause cardiovascular reflex changes that are predominantly bradycardiac and include either hyperor hypotension (8-10) ( Table 2). Nasal inhalation of cigarette smoke in rabbits causes hypertension and bradycardia (23) (Figure 1). Because the bradycardia is prevented by administration of atropine (5,8) it is mainly vagally mediated, but studies are limited on the possible additional involvement of the sympathetic innervation of the heart.…”
Section: Cardiovascular Reflex Responses To Pollutantsmentioning
confidence: 99%