Nasal Tumors of Olfactory Origin

Olfactory esthesioneuroblastoma

“…X-rays show in characteristic cases unilateral blurring of the maxillary antrum and ethmoid cell, whereas bone destruction is said to be rare (Friihling and Wild, 1954;Becker and Jacox, 1964;Lewis et al, 1965;Joachims et al, 1975). All our cases exhibited bone destruction.…”

Neuroblastomas and neuroendocrine carcinomas of the nasal cavity. A proposed new classification

“…In addition, there are published reports of nasal neuroblastomas that did not respond to radiotherapy. 15952- 55 From our study, it is clear that distant metastases, excluding brain and spine extension, are very rare in neuroblastomas and neuroendocrine carcinomas: we found only one case of neuroendocrine carcinoma with distant metastases. Although we do not deny the possibility that distant metastases might have occurred, we believe that the 20% figure for distant metastases reported in the literature is in part due to the lack of strict Most articles dealing with olfactory neuroblastoma report a 50% survival rate.6.7.50 In Bailey and Barton'sso series, the survival rate varies from 45% to 67%, depending on the treatment given.…”

Expression of human telomerase reverse transcriptase and cyclin‐D1 in olfactory neuroblastoma

“…Olfactory neuroblastoma is an uncommon malignant neuroendocrine neoplasm that arises from the olfactory mucosa. The division of olfactory neuroblastomas into subtypes, based on morphologic features, particularly the degree of epithelial versus neuronal differentiation, has been of prognostic value in some studies (3–4), but most have been unable to correlate morphology and prognosis (5–7). The Kadish staging system is applied to these tumors as follows: stage A, disease confined to the nasal cavity; stage B, disease confined to the nasal cavity and paranasal cavity; stage C, local or distant spread beyond the nasal cavity or sinuses (8).…”