Nasal application of kisspeptin-54 mitigates motor deficits by reducing nigrostriatal dopamine loss in hemiparkinsonian rats

Sinen, Osman; Sinen, Ayşegül Gemici; Derin, Narin; Aslan, Mutay Aydın

doi:10.1016/j.bbr.2024.115035

Cited by 1 publication

(1 citation statement)

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“…Microglia are proposed to play an important role in establishing aberrant neuronal circuitry in response to abnormal sex steroid exposure ( 18 ), and, thus, potentially also in the increased kisspeptin neuronal activity key to the pathogenesis of PCOS ( 19 ). Moreover, there is increasing recognition of potential roles of GnRH and kisspeptin beyond their more archetypal functions in the reproductive axis, including in Parkinson’s disease ( 20 ), cognition ( 21 ), and mood ( 22 ). Thus, it is likely that further uncovering the roles of nonneuronal cells, both in the reproductive axis and beyond, will continue to be an important focus of study.…”

Section: Discussionmentioning

confidence: 99%

Astrocytes: a star emerges in the control of reproductive hormones

Abbara,

Dhillo

2024

Journal of Clinical Investigation

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Kisspeptin is an essential neuropeptide sitting at the apex of the hypothalamo-pituitary-gonadal (HPG) endocrine axis to regulate gonadotropin-releasing hormone (GnRH) neurons and downstream reproductive hormones. Kisspeptin neurons integrate feedback from sex steroids facilitating regulation of the menstrual cycle and mediate the effects of metabolic stressors on the reproductive axis. In this issue of the JCI , Torres and colleagues describe another pathway for kisspeptin signaling in astrocytes to influence GnRH neuronal output. Astrocytes had kisspeptin receptors that activated canonical intracellular signaling pathways to constrain the magnitude of kisspeptin-induced GnRH neuronal stimulation. Additionally, the appositions between kisspeptin and GnRH neurons were dynamic during the ovarian cycle, with astrocyte kisspeptin signaling proposed as a putative modulator of this neuroplasticity. Importantly, astrocyte kisspeptin signaling also mediated susceptibility to metabolic stressors and the development of obesity-induced hypogonadism, underscoring the physiological and pathological importance of this pathway and revealing the importance of nonneuronal signaling in reproductive health.

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