Nasal administration of gentamicin using a novel microsphere delivery system

Ilium, Lisbeth; Farraj, Nidal F.; Critchley, Helen; Davis, S.S.

doi:10.1016/0378-5173(88)90087-7

Cited by 118 publications

(26 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4 Bioadhesive excipients such as starch, albumin, and diethyl aminoethyl (DEAE)-sephadex have been successfully used to reduce rapid nasal mucociliary clearance of formulations (eg, gentamicin, insulin). 5,6 Propranolol hydrochloride has been absorbed effectively from solution via the nasal route in human volunteers. 7 However, its short biological half-life and rapid absorption are unfavorable to sustain the drug levels in the systemic circulation.…”

Section: Introductionmentioning

confidence: 99%

Effect of organogel components on in vitro nasal delivery of propranolol hydrochloride

et al. 2004

View full text Add to dashboard Cite

The purpose of this research was to evaluate in vitro transnasal sustained-release ability of sorbitan monostearate (SMS) organogels in isopropyl myristate (IM). Organogels were prepared containing SMS (2.5%-20%) and water (5%-25%) in IM and analyzed microscopically for phase behavior. The effect of Tween surfactants on gel strength and in vitro nasal diffusion of propranolol is reported. The in vitro nasal release retardant effect of SMS and Tween 20 was investigated using factorial design. The microscopic changes in structure of organogel during in vitro nasal diffusion were studied. The water-holding capacity of SMS organogels in IM increased with SMS concentration. The release retardant effect with incorporation of cosurfactant was of the order of Tween 80 > Tween 60 > Tween 20. Gel strengthening and increased viscosity were evident with increased concentration of SMS and Tween 20. The 3-dimensional network of SMS molecules controls the diffusional drug release. The organogel system on nasal mucosa during diffusion is dynamic in nature and changes continuously with the time of diffusion. The water penetration in the organogel network results in percolation and emulsification of organogel, thus affecting the release. Organogels provided an effective barrier for diffusion of propranolol. The surface epithelium lining and the granular cellular structure of treated nasal mucosa were intact.

show abstract

Section: Introductionmentioning

confidence: 99%

Effect of organogel components on in vitro nasal delivery of propranolol hydrochloride

et al. 2004

View full text Add to dashboard Cite

show abstract

“…It would, therefore, be advantageous to have means for providing an intimate contact of the drug delivery system with the absorbing membranes. [5][6][7][8] This can be achieved by coupling bioadhesion characteristics to microspheres and developing bioadhesive microspheres. Bioadhesive microspheres have advantages such as efficient absorption and enhanced bioavailability of drugs owing to a high surface-to-volume ratio, a much more intimate contact with the mucus layer, and specific targeting of drugs to the absorption site.…”

Section: Introductionmentioning

confidence: 99%

Formulation and evaluation of mucoadhesive glipizide microspheres

Patel¹,

Patel²,

Amin

et al. 2005

AAPS PharmSciTech

View full text Add to dashboard Cite

The purpose of this research was to formulate and systematically evaluate in vitro and in vivo performances of mucoadhesive microspheres of glipizide. Glipizide microspheres containing chitosan were prepared by simple emulsification phase separation technique using glutaraldehyde as a cross-linking agent. Results of preliminary trials indicate that volume of cross-linking agent, time for cross-linking, polymer-to-drug ratio, and speed of rotation affected characteristics of microspheres. Microspheres were discrete, spherical, and free flowing. The microspheres exhibited good mucoadhesive property in the in vitro wash-off test and also showed a high percentage drug entrapment efficiency. A 3 2 full factorial design was employed to study the effect of independent variables, polymer-to-drug ratio (X 1 ), and stirring speed (X 2 ) on dependent variables percentage mucoadhesion, t 80 , drug entrapment efficiency, and swelling index. The best batch exhibited a high drug entrapment efficiency of 75% and a swelling index of 1.42; percentage mucoadhesion after 1 hour was 78%. The drug release was also sustained for more than 12 hours. The polymer-to-drug ratio had a more significant effect on the dependent variables. In vivo testing of the mucoadhesive microspheres to albino Wistar rats demonstrated significant hypoglycemic effect of glipizide.

show abstract

“…It was suggested that the biological enhancers such as lysophosphatidylcholine (LPC) increases the extent of drug absorption even further when combined with DSM [41][42][43] . DSM has an added advantage of protecting the proteins wrapped in it against degradation by proteases in the mucosa.…”

Section: Mucoadhesive Polymers Used In Nasal Drug Deliverymentioning

confidence: 99%

Untitled

2017

IJPSR

View full text Add to dashboard Cite

Nasal drug delivery has been recognized as a promising route for delivery of therapeutic compounds including biopharmaceuticals. It has been demonstrated that absorption of drugs can enhanced by using absorption enhancers or increasing the drug residence time in the nasal cavity. Mucoadhesive polymers can serve both functions. The residence time in the nasal cavity is considerably increased for microspheres compared to solutions. However, this is not the only factor to increase the absorption of large hydrophilic drugs. Microspheres also exert a direct effect on the mucosa, resulting in the opening of tight junctions between the epithelial cells. This review focuses on the background of nasal mucoadhesive drug delivery with special references to the biological and pharmaceutical considerations for nasal mucoadhesive drug administration.

show abstract

Nasal administration of gentamicin using a novel microsphere delivery system

Cited by 118 publications

References 14 publications

Effect of organogel components on in vitro nasal delivery of propranolol hydrochloride

Effect of organogel components on in vitro nasal delivery of propranolol hydrochloride

Formulation and evaluation of mucoadhesive glipizide microspheres

Untitled

Contact Info

Product

Resources

About