Narrow-bore liquid chromatography coupled to chemiluminescence detection for the analysis of pharmaceutical preparations containing hydrochlorothiazide and captopril

Principles and recent analytical applications of chemiluminescence

“…Analytical use of TCPO in LC has been reported [96]. Recent use of HPLC-coupled CL-flow injection analysis has been applied to the analysis of thiolic drugs based on CL produced by a Ce(IV) oxidation system sensitised by quinine and rhodamine B, such as hydrochlorothiazide and captopril [97,98] and the determination of tiopronin and its metabolite 2-mercaptopropionic acid in human urine [99].…”

FI-chemiluminometric study of thiazides by on-line photochemical reaction

“…However, a complicated instrumental set-up is necessary for the electro-generation of CL, and the system shows important interferences from organic amines. A second CL system developed by Ouyang et al [23][24][25][26], was based on the reaction of HCT with Ce(IV) in sulphuric acid, sensitized by Rhodamine 6G.…”