Narrative Review of Biological Markers in Chronic Limb-Threatening Ischemia
Alexandra Ioana Popescu,
Andreea Luciana Rata,
Sorin Barac
et al.
Abstract:Background: Chronic limb-threatening ischemia (CLTI), the advanced stage of peripheral arterial disease, is diagnosed in the presence of ischemic rest pain, non-healing ulcers, or gangrene. Several studies have demonstrated that inflammation and endothelial dysfunction are some of the main substrates of CLTI. Methods: A narrative review was conducted and reported according to PRISMA guidelines. Three databases were searched—Web of Science, Medline, and EMBASE—for the studies assessing CLTI and the biological m… Show more
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