Narcolepsy

Narcolepsy Type 1: A Remitting Disease? An Unusual Case Report

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Narcolepsy Type 1: A Remitting Disease? An Unusual Case Report

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Reduced Leptin Levels in Human Narcolepsy

“…The sleep of leptin-deficient mice has not been investigated, but hypocretin-deficient mice display increased amounts of REM sleep and sleep-onset REM periods [5]. Therefore, in a simple model, a deficiency of leptin or hypocretin, or both, in narcolepsy could lead to REM sleep disinhibition finally resulting in advanced onset REM periods, increased REM density [15], hypnagogic hallucinations, finally resulting in advanced onset REM periods, increased REM density [15], hypnagogic hallucinations, sleep paralysis and cataplexy [1]. In contrast to the synergistic effects of leptin and hypocretin on REM sleep, non-REM sleep is increased by leptin administration [13], but decreased by hypocretin [14].…”

Hla and Disease

“…As the predicted number of genes within the HLA region increases, it seems likely that similar examples might emerge. This is a particularly attractive hypothesis for diseases that have no apparent immunological basis, such as narcolepsy 24 or haemochromatosis.…”

Narcolepsy Type 1: A Remitting Disease? An Unusual Case Report

“……”

Reduced Leptin Levels in Human Narcolepsy

“…The sleep of leptin-deficient mice has not been investigated, but hypocretin-deficient mice display increased amounts of REM sleep and sleep-onset REM periods [5]. Therefore, in a simple model, a deficiency of leptin or hypocretin, or both, in narcolepsy could lead to REM sleep disinhibition finally resulting in advanced onset REM periods, increased REM density [15], hypnagogic hallucinations, finally resulting in advanced onset REM periods, increased REM density [15], hypnagogic hallucinations, sleep paralysis and cataplexy [1]. In contrast to the synergistic effects of leptin and hypocretin on REM sleep, non-REM sleep is increased by leptin administration [13], but decreased by hypocretin [14].…”

Hla and Disease

“…As the predicted number of genes within the HLA region increases, it seems likely that similar examples might emerge. This is a particularly attractive hypothesis for diseases that have no apparent immunological basis, such as narcolepsy 24 or haemochromatosis.…”

Narcolepsy Type 1: A Remitting Disease? An Unusual Case Report

“……”

Reduced Leptin Levels in Human Narcolepsy

“…The sleep of leptin-deficient mice has not been investigated, but hypocretin-deficient mice display increased amounts of REM sleep and sleep-onset REM periods [5]. Therefore, in a simple model, a deficiency of leptin or hypocretin, or both, in narcolepsy could lead to REM sleep disinhibition finally resulting in advanced onset REM periods, increased REM density [15], hypnagogic hallucinations, finally resulting in advanced onset REM periods, increased REM density [15], hypnagogic hallucinations, sleep paralysis and cataplexy [1]. In contrast to the synergistic effects of leptin and hypocretin on REM sleep, non-REM sleep is increased by leptin administration [13], but decreased by hypocretin [14].…”

Hla and Disease

“…As the predicted number of genes within the HLA region increases, it seems likely that similar examples might emerge. This is a particularly attractive hypothesis for diseases that have no apparent immunological basis, such as narcolepsy 24 or haemochromatosis.…”