Nanotubes mediate niche–stem-cell signalling in the Drosophila testis

Inaba, Mayu; Buszczak, Michael; Yamashita, Yukiko

doi:10.1038/nature14602

Cited by 182 publications

(200 citation statements)

References 35 publications

Supporting

Mentioning

189

Contrasting

Order By: Relevance

“…The stem cell niche may provide such an example. Indeed, the formation of a nanotube network to induce a precise local induction of signaling between stem cells and supporting cells has been shown to regulate stem cell behavior (Inaba et al, 2015). A recent study has revealed the importance of the niche architecture as well as of paracrine Wnt signaling, which regulates cell behavior in a wide variety of cell lineages (Wabik and Jones, 2015).…”

Section: Cytonemes In the Stem Cell Nichementioning

confidence: 99%

Role of cytonemes in Wnt transport

Stanganello

Scholpp

2016

Journal of Cell Science

View full text Add to dashboard Cite

Wnt signaling regulates a broad variety of processes during embryonic development and disease. A hallmark of the Wnt signaling pathway is the formation of concentration gradients by Wnt proteins across responsive tissues, which determines cell fate in invertebrates and vertebrates. To fulfill its paracrine function, trafficking of the Wnt morphogen from an origin cell to a recipient cell must be tightly regulated. A variety of models have been proposed to explain the extracellular transport of these lipid-modified signaling proteins in the aqueous extracellular space; however, there is still considerable debate with regard to which mechanisms allow the precise distribution of ligand in order to generate a morphogenetic gradient within growing tissue. Recent evidence suggests that Wnt proteins are distributed along signaling filopodia during vertebrate and invertebrate embryogenesis. Cytoneme-mediated transport has profound impact on our understanding of how Wnt signaling propagates through tissues and allows the formation of a precise ligand distribution in the recipient tissue during embryonic growth. In this Commentary, we review extracellular trafficking mechanisms for Wnt proteins and discuss the growing evidence of cytoneme-based Wnt distribution in development and stem cell biology. We will also discuss their implication for Wnt signaling in the formation of the Wnt morphogenetic gradient during tissue patterning.

show abstract

Section: Cytonemes In the Stem Cell Nichementioning

confidence: 99%

Role of cytonemes in Wnt transport

Stanganello

Scholpp

2016

Journal of Cell Science

View full text Add to dashboard Cite

show abstract

“…Retrograde IFT occurs over a distance of about 209 nm and moves along A-microtubules (Pigino et al, 2009;Stepanek and Pigino, 2016). In addition, IFT proteins also function in other cellular processes, including vesicle exocytosis, cell division and the formation of immunological synapses and microtubule-based nanotubes (Baldari and Rosenbaum, 2010;Borovina and Ciruna, 2013;Griffiths et al, 2010;Inaba et al, 2015;Wood et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Intraflagellar transport protein IFT52 recruits IFT46 to the basal body and flagella

Wan

Täschner

et al. 2017

Journal of Cell Science

View full text Add to dashboard Cite

Cilia are microtubule-based organelles and perform motile, sensing and signaling functions. The assembly and maintenance of cilia depend on intraflagellar transport (IFT). Besides ciliary localization, most IFT proteins accumulate at basal bodies. However, little is known about the molecular mechanism of basal body targeting of IFT proteins. We first identified the possible basal body-targeting sequence in IFT46 by expressing IFT46 truncation constructs in an ift46-1 mutant. The C-terminal sequence between residues 246-321, termed BBTS3, was sufficient to target YFP to basal bodies in the ift46-1 strain. Interestingly, BBTS3 is also responsible for the ciliary targeting of IFT46. BBTS3::YFP moves bidirectionally in flagella and interacts with other IFT complex B (IFT-B) proteins. Using IFT and motor mutants, we show that the basal body localization of IFT46 depends on IFT52, but not on IFT81, IFT88, IFT122, FLA10 or DHC1b. IFT52 interacts with IFT46 through residues L285 and L286 of IFT46 and recruits it to basal bodies. Ectopic expression of the C-terminal domain of IFT52 in the nucleus resulted in accumulation of IFT46 in nuclei. These data suggest that IFT52 and IFT46 can preassemble as a complex in the cytoplasm, which is then targeted to basal bodies.

show abstract

“…Examples include Drosophila male germline stem cells, in which daughter cells require physical contact with the hub (a group of supporting cells) to maintain stemness (Inaba et al, 2015;Yamashita et al, 2005). During stomatal development, EPF1-ERL1/TMM peptide-receptor kinase signaling is required to orient the polarity of the asymmetric spacing divisions .…”

Section: Signal Integration Controlling Upstream Signaling Ligandsmentioning

confidence: 99%

Lineage-specific stem cells, signals and asymmetries during stomatal development

Han

Torii

2016

Development

View full text Add to dashboard Cite

Stomata are dispersed pores found in the epidermis of land plants that facilitate gas exchange for photosynthesis while minimizing water loss. Stomata are formed from progenitor cells, which execute a series of differentiation events and stereotypical cell divisions. The sequential activation of master regulatory basic-helix-loop-helix (bHLH) transcription factors controls the initiation, proliferation and differentiation of stomatal cells. Cell-cell communication mediated by secreted peptides, receptor kinases, and downstream mitogenactivated kinase cascades enforces proper stomatal patterning, and an intrinsic polarity mechanism ensures asymmetric cell divisions. As we review here, recent studies have provided insights into the intrinsic and extrinsic factors that control stomatal development. These findings have also highlighted striking similarities between plants and animals with regards to their mechanisms of specialized cell differentiation.

show abstract

Nanotubes mediate niche–stem-cell signalling in the Drosophila testis

Cited by 182 publications

References 35 publications

Role of cytonemes in Wnt transport

Role of cytonemes in Wnt transport

Intraflagellar transport protein IFT52 recruits IFT46 to the basal body and flagella

Lineage-specific stem cells, signals and asymmetries during stomatal development

Contact Info

Product

Resources

About