Nanotechnology-Based Drug Delivery Systems for Treatment of Tuberculosis—A Review

Silva, Patrícia Bento da; Freitas, Eduardo Sinésio de; Bernegossi, Jéssica; Gonçalez, Maíra Lima; Sato, Mariana Rillo; Leite, Clarice Queico Fujimura; Pavan, Fernando Rogério; Chorilli, Marlus

doi:10.1166/jbn.2016.2149

Cited by 48 publications

(25 citation statements)

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“…Over the last few decades, nanoparticle based drug delivery systems have been explored to achieve sustained and targeted release of drugs . Poly (lactic‐co‐glyocolic) acid (PLGA) nanoparticles have been shown to achieve controlled release of drugs thus increasing their bioavailability in plasma .…”

Section: Introductionmentioning

confidence: 99%

Targeting wild‐type and drug‐resistant mycobacteria in infected macrophages using drug‐coated nanoparticles

Cotta

Padwal

Agarwal

et al. 2018

J of Chemical Tech & Biotech

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BACKGROUND: Tuberculosis therapeutics is facing a crisis because of the emergence of new multi and total drug-resistant strains of Mycobacterium tuberculosis. Increasing intra-bacterial as well as intra-macrophage drug concentrations through nanoparticles is a promising approach to target resistant bacteria. RESULTS:To target both wild-type (WT) and resistant Mycobacterium smegmatis (NOR r ), positively-charged norfloxacin-coated iron oxide nanoparticles (NOR@IONP) were synthesized. While these particles are taken up identically in both WT and NOR r , drug uptake was up to 4-fold higher in cells treated with NOR@IONP compared with the corresponding free drug. This increased intracellular drug accumulation also translated to an enhanced rate of bacterial killing, as is observed in the kill kinetics study. The coated nanoparticles also proved to be effective in reducing the minimum inhibitory concentration (MIC) of NOR towards Mycobacterium bovis BCG strain. Further, the effectiveness of NOR@IONP was also studied against differentiated THP1 cells infected with WT or NOR r M. smegmatis. Intracellular bacterial clearance studies indicated that the NOR concentration required to kill intracellular WT or drug-resistant bacteria is 2-fold lower when treated with NOR@IONP. CONCLUSION: This antibiotic-coated nanoparticle formulation is a novel antimicrobial agent with the potential to target both WT and resistant strains of mycobacteria present intracellularly. Surface interaction of NOR@IONP with WT and NOR r mutantSurface attachment of nanoparticles on bacterial cells was visualized by Cryo-FEG SEM [JSM-7600F equipped with Cryo unit (PP3000T) by Quorum]. Cells were incubated with NOR@IONP for 4 h at 37 ∘ C and then centrifuged at 6500 rpm for 10 min. The pellet J Chem Technol Biotechnol 2019; 94: 768-776

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Section: Introductionmentioning

confidence: 99%

Targeting wild‐type and drug‐resistant mycobacteria in infected macrophages using drug‐coated nanoparticles

Cotta

Padwal

Agarwal

et al. 2018

J of Chemical Tech & Biotech

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“…It demonstrates unique advantages based on its physiological features, such as it has large speci c surface and low thickness for drug absorption and permeability [3]. Compared with traditional oral administration, the reduced metabolic response of the lung decreases the degradation of the drug, avoiding the rst-pass effect of the liver [4]. PDDS also improves patient compliance compared to the injection administration [5].…”

Section: Introductionmentioning

confidence: 99%

Micelles Self-Assembled by 3-O-β-D-Glucopyranosyl Latycodigenin Enhance Cell Membrane Permeability, Promote Antibiotic Pulmonary Targeting and Improve Anti-infective Efficacy

Zhang

Huang

et al. 2020

Preprint

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Background: Nanoparticle-based pulmonary drug delivery systems are commonly developed and applied for drug-targeted delivery. It exhibits significant advantages compared to traditional pulmonary drug delivery systems. However, developing a formulation for each drug is a time-consuming and laborious task. Results: This study designed and constructed a universal lung-targeting nanoparticle. The self-assembled micelles were composed of a platycodon secondary saponin, 3-O-β-D-glucopyranosyl platycodigenin 682 (GP-682), via its specific amphiphilic structure. GP-682 micelles obtained a relatively stable zeta potential with a particle size between 60 to 90 nm, and the critical micelle concentration (CMC) value was approximately 42.3 μg/mL. Pre-incubation of GP-682 micelles markedly enhanced the cell membrane permeability, and improved drug uptake in vitro. The results were visualized using fluorescent dye tracing, transmission electron microscopy (TEM) observation and lactate dehydrogenase (LDH) releasing assay. The benefits enhanced the distribution of levofloxacin (Lev) in mouse lung tissue and reduced the overdosing of antibiotics. The acute lung injury mice model induced by Pseudomonas aeruginosa PA 14 strain demonstrated that pre-injection of GP-682 micelles before antibiotic administration produced a higher survival rate and anti-infective efficacy in vivo. It included a reduction in pulmonary injury, bacterial invasion and cytokines expression compared to treatment with Lev alone. Conclusions: GP-682 micelles are another nanoparticle-based pulmonary drug delivery system and provides a new option for lung-targeting therapy.

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“…A recent review thoroughly describes the considerable potential that nanoparticle‐based drug delivery systems encapsulating for example RF can provide in the treatment of TB. Polymer‐based systems of, for example, polylactic acid (PLA) comprise one category of promising drug delivery systems . Mesoporous silica particles functionalised with polyethyleneimine or with a pH‐responsive nanovalve were used for delivery of RF and isoniazid, respectively .…”

Section: Introductionmentioning

confidence: 99%

“…Polymer-based systems of, for example, polylactic acid (PLA) comprise one category of promising drug delivery systems. [14] Mesoporous silica particles functionalised with polyethyleneimine or with a pHresponsive nanovalve were used for delivery of RF and isoniazid, respectively. [15] Polymeric nano-and microparticles containing RF and other drugs, with or without surface modification, have also shown to be taken up into macrophages.…”

Section: Introductionmentioning

confidence: 99%

Poly(ethylene carbonate)-containing polylactic acid microparticles with rifampicin improve drug delivery to macrophages

Priemel

Wang

Bohr

et al. 2018

Journal of Pharmacy and Pharmacology

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Nanotechnology-Based Drug Delivery Systems for Treatment of Tuberculosis—A Review

Cited by 48 publications

References 0 publications

Targeting wild‐type and drug‐resistant mycobacteria in infected macrophages using drug‐coated nanoparticles

Targeting wild‐type and drug‐resistant mycobacteria in infected macrophages using drug‐coated nanoparticles

Micelles Self-Assembled by 3-O-β-D-Glucopyranosyl Latycodigenin Enhance Cell Membrane Permeability, Promote Antibiotic Pulmonary Targeting and Improve Anti-infective Efficacy

Poly(ethylene carbonate)-containing polylactic acid microparticles with rifampicin improve drug delivery to macrophages

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