Nanotechnological Interventions for Drug Delivery in Eye Diseases

Ingle, Avinash P.; Paralikar, Priti; Grupenmacher, Alex Treiger; Padovani, Felipe Hering; Ferrer, Marilia Trindade; Rai, Mahendra; Alves, Mônica

doi:10.1007/978-3-319-70299-5_12

Cited by 4 publications

(7 citation statements)

References 127 publications

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“…The detailed anatomical structure of the eye and its routes of administration are presented in Figure 1. The anatomical structure of the eye is composed of two parts, i.e., anterior segment and posterior segment [15][16][17][18][19]. Paracellular and transcellular are the two routes for penetration of drugs into the corneal epithelium.…”

Section: Anatomical Structure Of Eyementioning

confidence: 99%

“…Depending on the particle charge, surface characteristics and relative hydrophobicity, nanoparticles can be designed to overcome the retinal barriers, including the blood-retinal barrier. Additionally, nanosystems can provide protection to the drug from degradation and are able to release the encapsulated drug in a controlled and sustained fashion [15,16].…”

Section: Nanotechnology In Overcoming the Barriers Of Topical Delivermentioning

confidence: 99%

“…Polymers that are commonly used for preparing nanoparticles are poly-ε-caprolactone (PCL), chitosan, poly-(lactic-co-glycolic acid) (PLGA), carbopol, gelatin, Eudragit ® (RS100 and RL100), hyaluronic acid and so forth [4]. Gold, silver, silica and cerium oxide nanoparticles are also used as drug carriers for ocular delivery [15]. Nanocapsules and nanospheres are the two main types of nanoparticles with distinct structures.…”

Section: Nanoparticlesmentioning

confidence: 99%

“…Their ability to bind with cellular barriers and improve penetration of drugs through the cornea may be attributed to their similarity in size range to the membrane proteins, scleral pores (cornea), and other biomolecules. Polymeric micelles are a potential carrier to deliver hydrophobic drugs and proteins through biological membranes, to increase the chemical stability of unstable compounds, and to control the release of drugs [15,45].…”

Section: Polymeric Micellesmentioning

confidence: 99%

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Evolution of Nanotechnology in Delivering Drugs to Eyes, Skin and Wounds via Topical Route

et al. 2020

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The topical route is the most preferred one for administering drugs to eyes, skin and wounds for reaching enhanced efficacy and to improve patient compliance. Topical administration of drugs via conventional dosage forms such as solutions, creams and so forth to the eyes is associated with very low bioavailability (less than 5%) and hence, we cannot rely on these for delivering drugs to eyes more efficiently. An intravitreal injection is another popular drug delivery regime but is associated with complications like intravitreal hemorrhage, retinal detachment, endophthalmitis, and cataracts. The skin has a complex structure that serves as numerous physiological barriers to the entry of exogenous substances. Drug localization is an important aspect of some dermal diseases and requires directed delivery of the active substance to the diseased cells, which is challenging with current approaches. Existing therapies used for wound healing are costly, and they involve long-lasting treatments with 70% chance of recurrence of ulcers. Nanotechnology is a novel and highly potential technology for designing formulations that would improve the efficiency of delivering drugs via the topical route. This review involves a discussion about how nanotechnology-driven drug delivery systems have evolved, and their potential in overcoming the natural barriers for delivering drugs to eyes, skin and wounds.

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Section: Anatomical Structure Of Eyementioning

confidence: 99%

Section: Nanotechnology In Overcoming the Barriers Of Topical Delivermentioning

confidence: 99%

Section: Nanoparticlesmentioning

confidence: 99%

Section: Polymeric Micellesmentioning

confidence: 99%

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Evolution of Nanotechnology in Delivering Drugs to Eyes, Skin and Wounds via Topical Route

et al. 2020

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“…corneal stroma) for a long time. Nanotechnology is a promising technology, which has an enormous potential to solve a wide range of problems in various fields including biomedical area [25]. As far as the mycotic keratitis is concerned, nanotechnology can provide effective treatment solution for it.…”

Section: Nanotechnology As a Tool For Treatment Of Mycotic Keratitismentioning

confidence: 99%

Evolving nanotechnological trends in the management of mycotic keratitis

Rai

Grupenmacher

Ingle

et al. 2019

IET nanobiotechnol.

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The alarming increase in global burden of various corneal diseases in general and mycotic keratitis in particular has raised up a major concern for its treatment. Mycotic keratitis is one of the most serious infections among the various ocular diseases. The proper diagnosis and effective treatment strategies remain a great challenge for ophthalmologists. The inefficacy and failure of conventional treatments have generated need to develop alternative approaches for the treatment of mycotic keratitis. Considering the promising applications of nanotechnology in biomedical area, it is believed that various nanomaterials can be effectively used in the management of mycotic keratitis. This review focuses on worldwide burden of various corneal diseases including mycotic keratitis and the role of nanotechnology in its treatment. In addition, safety and toxicological issues are also discussed.

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