Nanostructured Polylactic Acid/Candeia Essential Oil Mats Obtained by Electrospinning

Mori, Cláudia Lopes Selvati de Oliveira; Passos, Nathália Almeida dos; Oliveira, Juliano Elvis de; Altoé, Thiza Falqueto; Mori, Fábio Akira; Mattoso, Luiz H. C.; Scolforo, José Roberto Soares; Tonoli, Gustavo Henrique Denzin

doi:10.1155/2015/439253

Cited by 51 publications

(29 citation statements)

References 41 publications

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“…This indicates that the crystallization of PLA becomes easier due to the increased chain mobility caused by the Plai oil. This similar effect was also observed in candeia oil loaded PLA fiber mat [37] and PLA/essential oil (i.e., bergamot, lemongrass, rosemary, or clove oil) blends [38].…”

Section: Preparation and Characterization Of Oil Loaded Electrospun Fsupporting

confidence: 73%

Electrospun poly(lactic acid) nanofiber mats for controlled transdermal delivery of essential oil from Zingiber cassumunar Roxb

Wongkanya

Teeranachaideekul

Makarasen

et al. 2020

Mater. Res. Express

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A controlled release system of Plai (Zingiber cassumunar Roxb.) oil based on electrospun poly(lactic) acid (PLA) nanofiber mat was successfully developed. The physicochemical properties of the nanofibers loaded with select amounts of oil (15%, 20%, and 30% wt) were characterized using various techniques, including a morphological study using scanning electron microscopy (SEM), structural determination using Fourier transform infrared spectrometry (FTIR) and x-ray diffraction (XRD), as well as thermal properties study using differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). The loading content and the entrapment efficiency of Plai oil within the fiber mats were evaluated and were found to be remarkably high, ensuring that PLA was an appropriate material for Plai oil loading. The ability of the nanofiber mats to release (E)-1-(3,4dimethoxyphenyl) butadiene (DMPBD) was also examined and the fiber mats showed controlled release characteristics. As the nanofiber mats have particularly high specific surface area with fully accessible and interconnected pore structures, a liquid medium with active ingredients will not be trapped in blind pores but can be fully released out of the fiber matrix. Furthermore, in vitro skin permeation of the active compound as well as a skin irritation were assessed using reconstructed human epidermis (EpiSkin TM ). It was found that DMPBD could efficiently penetrate through the skin model. Moreover, the nanofiber mats containing Plai oil also showed no skin irritation, indicating them as promising prototypes for medical applications.

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Section: Preparation and Characterization Of Oil Loaded Electrospun Fsupporting

confidence: 73%

Electrospun poly(lactic acid) nanofiber mats for controlled transdermal delivery of essential oil from Zingiber cassumunar Roxb

Wongkanya

Teeranachaideekul

Makarasen

et al. 2020

Mater. Res. Express

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“…SEM images showed that the bead-free and porous morphology of nanofibre mats are preserved but the collagen nanofibre diameter increased from 342 nm, to 471 nm for collagen nanofibres loaded with thyme essential oil and to 580 nm for collagen nanofibres loaded with oregano essential oil, in agreement with phenol content. The influence of essential oil on nanofibre diameter increase was found also for clove essential oil included in electrospun poly(ε-caprolactone)/gelatin nanofibres [63], fish oil encapsulated in poly(vinyl alcohol) nanofibres [64] and candeia essential oil included in polylactic acid nanofibres [65] and was attributed to electrical conductivity and viscosity changes. EDX analyses confirmed higher concentration of carbon in essential oil loaded nanofibres, with higher values for oregano oil loaded nanofibres.…”

Section: Discussionmentioning

confidence: 68%

Bioactive Properties of Nanofibres Based on Concentrated Collagen Hydrolysate Loaded with Thyme and Oregano Essential Oils

et al. 2020

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This research aimed to obtain biocompatible and antimicrobial nanofibres based on concentrated collagen hydrolysate loaded with thyme or oregano essential oils as a natural alternative to synthesis products. The essential oils were successfully incorporated using electrospinning process into collagen resulting nanofibres with diameter from 471 nm to 580 nm and porous structure. The presence of essential oils in collagen nanofibre mats was confirmed by Attenuated Total Reflectance -Fourier Transform Infrared Spectroscopy (ATR-FTIR), Ultraviolet–visible spectroscopy (UV–VIS) and antimicrobial activity. Scanning Electron Microscopy with Energy Dispersive Spectroscopy analyses allowed evaluating the morphology and constituent elements of the nanofibre networks. Microbiological tests performed against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans showed that the presence of essential oils supplemented the new collagen nanofibres with antimicrobial properties. The biocompatibility of collagen and collagen with essential oils was assessed by in vitro cultivation with NCTC clone 929 of fibroblastic cells and cell viability measurement. The results showed that the collagen and thyme or oregano oil composites have no cytotoxicity up to concentrations of 1000 μg·mL−1 and 500 μg mL−1, respectively. Optimization of electrospinning parameters has led to the obtaining of new collagen electrospun nanofibre mats loaded with essential oils with potential use for wound dressings, tissue engineering or protective clothing.

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“…Data obtained in this study indicated that the average fiber diameter slightly decreased with the addition of PEP from 1.6 ± 0.2 to 0.9 ± 0.2 µm ( Table 1). This could be due to the plasticizer effect of the essential oil (Mori et al, 2015). In this regard, PEP might be acting as a plasticizer, altering the order between single polymer chains and resulting in the decrease of solution viscosity.…”

Section: Discussionmentioning

confidence: 99%

Physical and Antibacterial Properties of Peppermint Essential Oil Loaded Poly (ε-caprolactone) (PCL) Electrospun Fiber Mats for Wound Healing

Ünalan

Slavik

Buettner

et al. 2019

Front. Bioeng. Biotechnol.

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The aim of this study was to fabricate and characterize various concentrations of peppermint essential oil (PEP) loaded on poly(ε-caprolactone) (PCL) electrospun fiber mats for healing applications, where PEP was intended to impart antibacterial activity to the fibers. SEM images illustrated that the morphology of all electrospun fiber mats was smooth, uniform, and bead-free. The average fiber diameter was reduced by the addition of PEP from 1.6 ± 0.1 to 1.0 ± 0.2 µm. Functional groups of the fibers were determined by Raman spectroscopy. Gas chromatography-mass spectroscopy (GC-MS) analysis demonstrated the actual PEP content in the samples. In vitro degradation was determined by measuring weight loss and their morphology change, showing that the electrospun fibers slightly degraded by the addition of PEP. The wettability of PCL and PEP loaded electrospun fiber mats was measured by determining contact angle and it was shown that wettability increased with the incorporation of PEP. The antimicrobial activity results revealed that PEP loaded PCL electrospun fiber mats exhibited inhibition against Staphylococcus aureus (gram-positive) and Escherichia coli (gram-negative) bacteria. In addition, an in-vitro cell viability assay using normal human dermal fibroblast (NHDF) cells revealed improved cell viability on PCL, PCLPEP1.5, PCLPEP3, and PCLGEL6 electrospun fiber mats compared to the control (CNT) after 48 h cell culture. Our findings showed for the first time PEP loaded PCL electrospun fiber mats with antibiotic-free antibacterial activity as promising candidates for wound healing applications.

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Nanostructured Polylactic Acid/Candeia Essential Oil Mats Obtained by Electrospinning

Cited by 51 publications

References 41 publications

Electrospun poly(lactic acid) nanofiber mats for controlled transdermal delivery of essential oil from Zingiber cassumunar Roxb

Electrospun poly(lactic acid) nanofiber mats for controlled transdermal delivery of essential oil from Zingiber cassumunar Roxb

Bioactive Properties of Nanofibres Based on Concentrated Collagen Hydrolysate Loaded with Thyme and Oregano Essential Oils

Physical and Antibacterial Properties of Peppermint Essential Oil Loaded Poly (ε-caprolactone) (PCL) Electrospun Fiber Mats for Wound Healing

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