Nanostructured Fibrous Membranes with Rose Spike-Like Architecture

Abstract

Nanoparticles have been used for engineering composite materials to improve the intrinsic properties and/or add functionalities to pristine polymers. The majority of the studies have focused on the incorporation of spherical nanoparticles within the composite fibers. Herein, we incorporate anisotropic branched-shaped zinc oxide (ZnO) nanoparticles into fibrous scaffolds fabricated by electrospinning. The addition of the branched particles resulted in their protrusion from fibers, mimicking the architecture of a rose stem. We demonstrated that the encapsulation of different-shape particles significantly influences the physicochemical and biological activities of the resultant composite scaffolds. In particular, the branched nanoparticles induced heterogeneous crystallization of the polymeric matrix and enhance the ultimate mechanical strain and strength. Moreover, the three-dimensional (3D) nature of the branched ZnO nanoparticles enhanced adhesion properties of the composite scaffolds to the tissues. In addition, the rose stem-like constructs offered excellent antibacterial activity, while supporting the growth of eukaryote cells.

The role of microRNAs and nanoparticles in ovarian cancer: a review

“…These miRNAs were over-expressed even in patients with early stages of ovarian cancer. The miRNA signatures from exosomes were equivalent from the originating tumour cells, indicating that circulating miRNA profiles precisely reflected the tumour profiles [67]. Following this study, a variety of reports have confirmed the diagnostic potential of circulating miRNAs in body fluids such as serum, plasma, whole blood and urine [68][69][70] as summarized in Table 1.…”

Antimicrobial and Osseointegration Properties of Nanostructured Titanium Orthopaedic Implants

“…The branched nanoparticles (spikes length: 1–5 μm; diameter: 50–200 nm) induced heterogeneous crystallization of the polymeric matrix. This three-dimensional composite enhances the mechanical strain and strength and offers excellent antibacterial activity, while supporting the growth of eukaryote cells [ 170 ]. Bounded to Ti surfaces these structures might improve osteocondutivity and inhibit proliferation of prokaryotes.…”

Current developments in green synthesis of metallic nanoparticles using plant extracts: a review

“…Furtherore, ZnO NPs are inexpensive and safe; US FDA has enlisted ZnO as GRAS (generally recognized as safe) metal oxide [36]. ZnO NPs have been used in cancer therapy, drug delivery and they posses antibacterial properties [37,38].…”