Nanostructure, porosity and tensile strength of PVA/Hydroxyapatite composite nanofiber for bone tissue engineering

Hartatiek,; Yudyanto, Yudyanto; Wuriantika, Maulia Ingganis; Utomo, Joko; Nurhuda, Muhammad; Masruroh, Masruroh; Santjojo, Dionysius Joseph Djoko Herry

doi:10.1016/j.matpr.2020.11.438

Cited by 17 publications

(7 citation statements)

References 22 publications

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“…The successful incorporation of HA was seen in the form of aggregation mass inside the fibre in the case of CNF-HA, and the average diameter was 150.5 ± 24.337 nm. The addition of HA also makes the surface of the fibre rougher, and this result is consistent with those of previous work ( Hartatiek et al, 2021 ). It should be remembered that the embedded HA produces a rough nanofiber surface, which is expected to increase surface wettability and encourage the attachment of bone cells and the formation of new bone differentiation ( Bodhak et al, 2009 ; Hartatiek et al, 2021 ).…”

Section: Resultssupporting

confidence: 93%

“…The addition of HA also makes the surface of the fibre rougher, and this result is consistent with those of previous work ( Hartatiek et al, 2021 ). It should be remembered that the embedded HA produces a rough nanofiber surface, which is expected to increase surface wettability and encourage the attachment of bone cells and the formation of new bone differentiation ( Bodhak et al, 2009 ; Hartatiek et al, 2021 ). Additionally, for CNF-SBG and CNF-BBG, respectively, the fiber diameter increased to (167.5 ± 6.9) nm and (123.5 ± 7.99) nm after silicate and borosilicate bioactive glass doping.…”

Section: Resultssupporting

confidence: 93%

“…The C=C bond is represented by the small peaks at 1961 cm −1 , 2033 cm −1 , and 2,222 cm −1 . Following HA reinforcement, peaks appear in the spectra at 1,030 cm −1 , 870 cm −1 , and 3,400 cm −1 corresponding to PO 4 3− , CO 3 2− , and OH of HA, respectively ( Manoj et al, 2015 ; Hartatiek et al, 2021 ). The CNF-SBG spectra demonstrate the silicate bioactive glass SBG’s distinctive absorption bands.…”

Section: Resultsmentioning

confidence: 99%

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Hydrothermally reinforcing hydroxyaptatite and bioactive glass on carbon nanofiber scafold for bone tissue engineering

El-Aziz

Serag

Kenawy

et al. 2023

Front. Bioeng. Biotechnol.

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As a bone tissue engineering scaffold, the objective of this study was to design hierarchical bioceramics based on an electrospun composite of carbon nanofibers (CNF) reinforced with hydroxyapatite (HA) and bioactive glasses (BGs) nanoparticles. The performance of the nanofiber as a scaffold for bone tissue engineering was enhanced by reinforcing it with hydroxyapatite and bioactive glass nanoparticles through a hydrothermal process. The influence of HA and BGs on the morphology and biological properties of carbon nanofibers was examined. The prepared materials were evaluated for cytotoxicity in vitro using the water-soluble tetrazolium salt assay (WST-assay) on Osteoblast-like (MG-63) cells, and oste-ocalcin (OCN), alkaline phosphatase (ALP) activity, total calcium, total protein, and tar-trate-resistant acid phosphatase (TRAcP) were measured. The WST-1, OCN, TRAcP, total calcium, total protein, and ALP activity tests demonstrated that scaffolds reinforced with HA and BGs had excellent in vitro biocompatibility (cell viability and proliferation) and were suitable for repairing damaged bone by stimulating bioactivity and biomarkers of bone cell formation.

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Section: Resultssupporting

confidence: 93%

Section: Resultssupporting

confidence: 93%

Section: Resultsmentioning

confidence: 99%

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Hydrothermally reinforcing hydroxyaptatite and bioactive glass on carbon nanofiber scafold for bone tissue engineering

El-Aziz

Serag

Kenawy

et al. 2023

Front. Bioeng. Biotechnol.

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“…The hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 ) was synthesized from limestone [27] The synthesis of PVA/Chitosan/PEG/HAp begins with the preparation of a PVA/Chitosan/PEG solution. First, 1% of chitosan was mixed with 2% of acetic acid and stirred using a magnetic stirrer at a speed of 700 rpm for 2 h at room temperature.…”

Section: Methodsmentioning

confidence: 99%

Surface modification of PVA/Chitosan/PEG/HAp nanofiber scaffolds by plasma treatment and studies of their morphology, wettability, and biodegradation rate

Hartatiek¹,

Wuriantika²,

Amalia³

et al. 2023

Adv. Nat. Sci: Nanosci. Nanotechnol.

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Nanofiber scaffold has been widely developed as a tissue engineering material because it can imitate the ECM of bones. In this study, nanofiber scaffold is composed of polyvinyl alcohol (PVA), chitosan, polyethylene glycol (PEG), and hydroxyapatite (HAp) which have superior characteristics for tissue engineering applications. The nanofiber scaffold is synthesized using electrospinning. Experimental results show that dielectric barrier discharge (DBD) plasma treatment causes increased surface roughness, contributing to the improvement of surface wettability. This is indicated by a decrease in this contact angle from 9.92° to 1.74°. In addition, DBD plasma treatment also increased biodegradation as well as increased treatment time.

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“…Pemilihan rasio perbandingan PVA:HAp sebesar 5:5, 6:4, 7:3, 8:2, dan 9:1 didasarkan pada penelitian oleh Hartatiek et.al, pada tahun 2021 mengenai komposit PVA/Hidroksiapatit menggunakan variabel serupa dengan hasil terbaik didapatkan pada variabel 7:3 [22]. Selain itu kekuatan mekanik, morfologi dari komposit juga dapat dimanipulasikan menggunakan variabel tersebut, dikarenakan ikatan silang kimia dari polimer PVA yang juga memberikan pengaruh kepada kekuatan mekanik komposit [23].…”

Section: Sifat Mekanik Kompositunclassified

Pembuatan Biokompatibel Komposit dari Nano Hidroksiapatit Berbahan Dasar Cangkang Keong Sawah (Pila ampullacea) dengan Kombinasi Biopolimer PVA (Polyvinyl Alcohol) sebagai Bahan Dasar Pembuatan Suture Anchor

Inayah,

Anggraeni,

Karisma

2023

JTek

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AbstrakPerbaikan robekan tendon suprasinatus pada rotator cuff dilakukan dengan menggunakan suture anchor. Baru-baru ini, suture anchor berbahan biodegradable mulai dikembangkan untuk mengatasi permasalahan akibat penggunaan bahan logam. Hidroksiapatit [Ca10(PO4)6(OH)2] atau HAp merupakan biokeramik kalsium fosfat yang memiliki kemiripan dengan mineral tulang. Sintesis HAp dengan metode presipitasi menggunakan prekursor kalsium dan fosfat, seperti kalsium hidroksida [Ca(OH)2] dan asam fosfat [H3PO4]. Kalsium hidroksida dapat diperoleh dari cangkang keong sawah dikarenakan hampir seluruh komposisinya merupakan kalsium karbonat. HAp biasanya dikombinasikan dengan polimer seperti Poly(vinyl Alcohol) (PVA) sebagai komposit untuk mengatasi keterbatasan sifat mekaniknya. Penelitian ini bertujuan untuk mengetahui pengaruh dari kombinasi pencampuran HAp dan PVA terhadap komposit yang dihasilkan sebagai bahan dasar pembuatan suture anchor. Variabel yang digunakan dalam penelitian ini yaitu rasio pencampuran PVA:HAP dengan rasio pencampuran, yaitu 5:5, 6:4, 7:3, 8:2, dan 9:1. Hasil karakterisasi sintesis Hap menunjukkan cangkang keong sawah dapat digunakan sebagai bahan baku sintesis HAp. Hasil uji mekanik menunjukan semakin meningkatnya konsentrasi PVA maka sifat mekanik komposit semakin tinggi. Hasil yang paling optimal pada variabel 9:1 dengan Tensile Strength 10,06 N/mm2, Max Force 107,6 N, dan Elongation 128,08%. Kata kunci: Composite, Hydroxyapatite, Poly Vinyl Alcohol, Rice Snail Shell, Suture Ancho

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Nanostructure, porosity and tensile strength of PVA/Hydroxyapatite composite nanofiber for bone tissue engineering

Cited by 17 publications

References 22 publications

Hydrothermally reinforcing hydroxyaptatite and bioactive glass on carbon nanofiber scafold for bone tissue engineering

Hydrothermally reinforcing hydroxyaptatite and bioactive glass on carbon nanofiber scafold for bone tissue engineering

Surface modification of PVA/Chitosan/PEG/HAp nanofiber scaffolds by plasma treatment and studies of their morphology, wettability, and biodegradation rate

Pembuatan Biokompatibel Komposit dari Nano Hidroksiapatit Berbahan Dasar Cangkang Keong Sawah (Pila ampullacea) dengan Kombinasi Biopolimer PVA (Polyvinyl Alcohol) sebagai Bahan Dasar Pembuatan Suture Anchor

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