Nanosilver: new ageless and versatile biomedical therapeutic scaffold

Abstract

Silver nanotechnology has received tremendous attention in recent years, owing to its wide range of applications in various fields and its intrinsic therapeutic properties. In this review, an attempt is made to critically evaluate the chemical, physical, and biological synthesis of silver nanoparticles (AgNPs) as well as their efficacy in the field of theranostics including microbiology and parasitology. Moreover, an outlook is also provided regarding the performance of AgNPs against different biological systems such as bacteria, fungi, viruses, and parasites (leishmanial and malarial parasites) in curing certain fatal human diseases, with a special focus on cancer. The mechanism of action of AgNPs in different biological systems still remains enigmatic. Here, due to limited available literature, we only focused on AgNPs mechanism in biological systems including human (wound healing and apoptosis), bacteria, and viruses which may open new windows for future research to ensure the versatile application of AgNPs in cosmetics, electronics, and medical fields.

Comprehensive Evaluation of the Biological Properties of Surface-Modified Titanium Alloy Implants

“…In contrast, TNT15 and TNT15/AgNPs enhanced production of these mediators. Moreover, presence of AgNPs on the surface of nanotubes potentiated the anti-inflammatory activities of all tested specimens According to previous reports, silver nanoparticles show the potent anti-inflammatory effect and accelerate wound healing, however the possible cytotoxic effect on mammalian cells was also observed [49,61]. These results indicate that TNT5 coatings are good candidates for manufacture of implants with anti-inflammatory properties, since inflammation has been associated with both delayed bone healing and pathogenic bone loss [62].…”

Flacourtia indica based biogenic nanoparticles: development, characterization, and bioactivity against wound associated pathogens

“…Many studies have been made to fabricate the AgNPs using plant leaves, stem, roots, and fruit such as Dalbergia spinosa, Sapindus emarginatus, Ficus hispida, Diospyros paniculata, and Berberis vulgaris [26][27][28][29][30]. These plant extracts are used as reducing as well as a capping agent for the AgNPs fabrication.…”

Drug repurposing for new, efficient, broad spectrum antivirals

“…AgNPs can be prepared by several techniques, including physical, chemical and biological methods. Depending on the size and the technique used to prepare the nanoparticles their properties and toxicity can vary (Thorley and Tetley, 2013;Ullah Khan et al, 2018).…”