Nanosilver inhibits the progression of pancreatic cancer by inducing a paraptosis-like mixed type of cell death

Liu, Li; An, Xuefeng; Schaefer, Michael; Yan, Bin; Torre, Carolina De La; Hillmer, Stefan; Gladkich, Jury; Herr, Ingrid

doi:10.1016/j.biopha.2022.113511

Cited by 5 publications

(5 citation statements)

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“…The influence of p62 and LC3-II proteins also indicates the involvement of autophagy, and the increase in MLKL phosphorylation is a marker of necroptosis. DNA fragmentation and caspase-3 activation were not significant; therefore, the authors assume that apoptosis was not the main cell death mechanism of tumor pancreatic cells [ 127 ].…”

Section: The Potential Of Agnps In Nano-oncologymentioning

confidence: 99%

The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future?

Takáč

Michalková

Čižmáriková

et al. 2023

Life

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Cancer is a fatal disease with a complex pathophysiology. Lack of specificity and cytotoxicity, as well as the multidrug resistance of traditional cancer chemotherapy, are the most common limitations that often cause treatment failure. Thus, in recent years, significant efforts have concentrated on the development of a modernistic field called nano-oncology, which provides the possibility of using nanoparticles (NPs) with the aim to detect, target, and treat cancer diseases. In comparison with conventional anticancer strategies, NPs provide a targeted approach, preventing undesirable side effects. What is more, nanoparticle-based drug delivery systems have shown good pharmacokinetics and precise targeting, as well as reduced multidrug resistance. It has been documented that, in cancer cells, NPs promote reactive oxygen species (ROS) production, induce cell cycle arrest and apoptosis, activate ER (endoplasmic reticulum) stress, modulate various signaling pathways, etc. Furthermore, their ability to inhibit tumor growth in vivo has also been documented. In this paper, we have reviewed the role of silver NPs (AgNPs) in cancer nanomedicine, discussing numerous mechanisms by which they render anticancer properties under both in vitro and in vivo conditions, as well as their potential in the diagnosis of cancer.

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Section: The Potential Of Agnps In Nano-oncologymentioning

confidence: 99%

The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future?

Takáč

Michalková

Čižmáriková

et al. 2023

Life

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“…A non-antibiotic tetracycline, tetracycline-3 (4-dedimethylamino sancycline, COL-3), causes cell death in chronic myeloid leukemia cell line through DNA damage and initiates paraptosis characterized by mitochondrial and ER stress ( Fares et al, 2022 ). High concentrations of DHW-221, a dual PI3K/mTOR inhibitor, induce a paraptotic effect in non-small lung cancer cells due to the activation of MAP kinase pathways and ER stress induction ( Liu et al, 2022b ). A polyphenolic flavonoid, Glabridin exhibits anti-tumour activity in breast cancer cell lines by inducing paraptosis in many human malignancies by elevating the expression of different ER stress markers like Bip, XBPIs, CHOP and by inducing ROS production and mitochondrial dysfunction ( Cui and Cui, 2022 ).…”

Section: Mechanism Of Paraptosismentioning

confidence: 99%

Paraptosis: a unique cell death mode for targeting cancer

Hanson,

Dharan,

P. V.

et al. 2023

Front. Pharmacol.

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Programmed cell death (PCD) is the universal process that maintains cellular homeostasis and regulates all living systems’ development, health and disease. Out of all, apoptosis is one of the major PCDs that was found to play a crucial role in many disease conditions, including cancer. The cancer cells acquire the ability to escape apoptotic cell death, thereby increasing their resistance towards current therapies. This issue has led to the need to search for alternate forms of programmed cell death mechanisms. Paraptosis is an alternative cell death pathway characterized by vacuolation and damage to the endoplasmic reticulum and mitochondria. Many natural compounds and metallic complexes have been reported to induce paraptosis in cancer cell lines. Since the morphological and biochemical features of paraptosis are much different from apoptosis and other alternate PCDs, it is crucial to understand the different modulators governing it. In this review, we have highlighted the factors that trigger paraptosis and the role of specific modulators in mediating this alternative cell death pathway. Recent findings include the role of paraptosis in inducing anti-tumour T-cell immunity and other immunogenic responses against cancer. A significant role played by paraptosis in cancer has also scaled its importance in knowing its mechanism. The study of paraptosis in xenograft mice, zebrafish model, 3D cultures, and novel paraptosis-based prognostic model for low-grade glioma patients have led to the broad aspect and its potential involvement in the field of cancer therapy. The co-occurrence of different modes of cell death with photodynamic therapy and other combinatorial treatments in the tumour microenvironment are also summarized here. Finally, the growth, challenges, and future perspectives of paraptosis research in cancer are discussed in this review. Understanding this unique PCD pathway would help to develop potential therapy and combat chemo-resistance in various cancer.

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“…Silver nanoparticles (AgNPs) trigger mixed cell death in PDAC, including apoptosis, autophagy, necrosis, necroptosis, and mitotic catastrophe. They achieve this by altering cell or organelle features, signaling pathways, and protein expression [165,166]. AgNPs also disrupt the antioxidant (SOD1, SOD2, GPX-4, CAT, and SOD3) system in PDAC cells and induce oxidative and nitro-oxidative mechanisms [167].…”

Section: Drugs That Modulate Necroptosis Signaling Pathwaysmentioning

confidence: 99%

“…Pancreatic cancer cells are more susceptible to AgNPs-induced cytotoxicity than non-tumor cells. Furthermore, AgNPs' cytotoxic effects on pancreatic cancer cells are sizeand concentration-dependent [165,166].…”

Section: Drugs That Modulate Necroptosis Signaling Pathwaysmentioning

confidence: 99%

“…Metallodrugs showed the potential to improve pancreatic cancer treatment in various ways, including the ability to pass the dense TME, improve photosensitivity, and induce the co-occurrence of different cell death pathways [165][166][167]. An innovative platinum-based metallodrug complex, SEP (quinone derivative seratrodast (STD) plus cisplatin (CDDP)), was developed to eliminate apoptosis-resistant PDAC.…”

Section: Combination Therapymentioning

confidence: 99%

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Genome, Metabolism, or Immunity: Which Is the Primary Decider of Pancreatic Cancer Fate through Non-Apoptotic Cell Death?

Barar,

Shi

2023

Biomedicines

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Pancreatic ductal adenocarcinoma (PDAC) is a solid tumor characterized by poor prognosis and resistance to treatment. Resistance to apoptosis, a cell death process, and anti-apoptotic mechanisms, are some of the hallmarks of cancer. Exploring non-apoptotic cell death mechanisms provides an opportunity to overcome apoptosis resistance in PDAC. Several recent studies evaluated ferroptosis, necroptosis, and pyroptosis as the non-apoptotic cell death processes in PDAC that play a crucial role in the prognosis and treatment of this disease. Ferroptosis, necroptosis, and pyroptosis play a crucial role in PDAC development via several signaling pathways, gene expression, and immunity regulation. This review summarizes the current understanding of how ferroptosis, necroptosis, and pyroptosis interact with signaling pathways, the genome, the immune system, the metabolism, and other factors in the prognosis and treatment of PDAC.

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Nanosilver inhibits the progression of pancreatic cancer by inducing a paraptosis-like mixed type of cell death

Cited by 5 publications

References 80 publications

The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future?

The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future?

Paraptosis: a unique cell death mode for targeting cancer

Genome, Metabolism, or Immunity: Which Is the Primary Decider of Pancreatic Cancer Fate through Non-Apoptotic Cell Death?

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