Nanoparticles/thermosensitive hydrogel reinforced with chitin whiskers as a wound dressing for treating chronic wounds

Xia, Guixue; Liu, Ya; Tian, Meiping; Gao, Ping; Bao, Zixian; Bai, Xiaoyu; Yu, Xiaoping; Lang, Xuqian; Hu, Shihao; Chen, Xiguang

doi:10.1039/c7tb00479f

Cited by 83 publications

(35 citation statements)

References 62 publications

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“…Then, the positively charged amino group can directly attack the negatively charged bacterial cell membrane via electrostatic attraction to disrupt the cell membrane to achieve a good antibacterial effect, which differs from target-specific interactions of conventional antibiotics and prevents drug resistance of bacteria from occurring to some extent [15][16][17]. By now, some CS-based wound dressing products have been developed in dosage forms of hydrogel [18,19], film [9], and sponge [20], among which hydrogel or hydrogel film is able to provide a moist environment to the wound, effectively preventing tissue dehydration and cell death, enhancing the migration of inflammatory cells and growth factors, facilitating air exchange and angiogenesis, serving as a microbial barrier, removing excessive exudate, and accelerating wound healing, among other merits, and thus has good application prospect [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Chitosan-Gentamicin Conjugate Hydrogel Promoting Skin Scald Repair

et al. 2020

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Our earlier research indicated that chitosan-gentamicin conjugate (CS-GT) possesses superior antimicrobial activity and good water solubility. To develop CS-GT-based scald dressings, the antibacterial properties of CS-GT were further studied, and the biosafety of CS-GT and the healing mechanism of CS-GT hydrogel was systematically explored in this article. It was found that cell viability shows a declined inclination with the prolonged culture time and the increased concentration of CS-GT. After three day’s culture, the cell viability could still remain at 79.72% when CS-GT concentration was as high as 1000 μg/mL. On the other hand, the hemolysis rate of CS-GT was lower than 5% when its concentration is 800 μg/mL. Therefore CS-GT has good cytocompatibility and hemocompatibility. A wound-healing experiment has shown that the skin healing rate of CS-GT hydrogel was the highest at 99.61%, followed by the positive control (wet burn ointment) 94.98%, GT hydrogel 87.50%, and matrix 77.39%. The blank control group, however, possessed the lowest healing rate of 75.45%. Further analysis indicated that CS-GT hydrogel could promote the synthesis of total protein (TP) in skin granulation tissue, resulting in the enhanced hydroxyproline (HYP) content, which facilitated collagen fibrogenesis, reduced cytokine expression in an inflammatory response, and, ultimately, accelerated wound healing. To sum up, CS-GT hydrogel is a promising scald dressing.

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Section: Introductionmentioning

confidence: 99%

Chitosan-Gentamicin Conjugate Hydrogel Promoting Skin Scald Repair

et al. 2020

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“…In this way, the drug loading of BSA in hydrogels could be completed with high efficiency. The thermosensitive HBC hydrogels have been developed and applied in the delivery of many kinds of drugs, such as 5‐FU (0.13 kDa), dexamethasone sodium phosphate (0.39 kDa), doxorubicine hydrochloride (0.58 kDa), linezolid (0.33 kDa), insulin (5.80 kDa), and bovine serum albumin (66.43 kDa). These reports indicated that the thermosensitive HBC‐based hydrogels could load soluble drugs easily and high‐efficiently with a wide range of molecular weights ranging from 0.13 to 66.43 kDa, which could be a potential drug delivery platform.…”

Section: Resultsmentioning

confidence: 99%

Chitosan‐Based Thermo/pH Double Sensitive Hydrogel for Controlled Drug Delivery

Bai

Bao

et al. 2018

Macromolecular Bioscience

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A series of thermo/pH sensitive N-succinyl hydroxybutyl chitosan (NSHBC) hydrogels with different substitution degrees of succinyl are prepared for drug delivery. Rheology analysis shows that the gelation temperature of NSHBC hydrogels is 3.8 °C higher than that of hydroxybutyl chitosan (HBC) hydrogels. A model drug bovine serum albumin (BSA) is successfully loaded and released. NSHBC hydrogels show excellent pH sensitivity drug release behaviors. After incubation for 24 h, 93.7% of BSA is released from NSHBC hydrogels in phosphate buffer saline (PBS) (pH 7.4), which is significantly greater than that of 24.6% at pH 3.0. In contrast, the release rate of BSA from HBC is about 70.0% at pH 3.0 and 7.4. Thus, these novel hydrogels have the prominent merits of high adaptability to soluble drugs and pH sensitivity triggered release, indicating that NSHBC hydrogels have promising applications in oral drug delivery.

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“…Cellular and immunological entrapment into the wound is commonly categorized into three main phases for wound restoration 1 (inflammation, proliferation and remodelling). Chronic wounds are recognized by the deterioration in their wound healing process leading to putrefaction, infection or even resection 2 . The typical properties of the wound treating material includes having an anti-infective effect 3 , therefore, it is intended to use antimicrobial agents loaded onto nanomaterials for enhancing the wound recovery rate with controlled release and high penetration power.…”

Section: Introductionmentioning

confidence: 99%

New Approach in Ulcer Prevention and Wound Healing Treatment using Doxycycline and Amoxicillin/LDH Nanocomposites

El-Ela

Farghali

Mahmoud

et al. 2019

Sci Rep

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Doxycycline (DOX) and amoxicillin (AMOX) are important Broad-spectrum antibiotics used in treating multiple human and animal diseases. For the sake of exploring novel medical applications, both antibiotics were loaded into magnesium aluminium layer double hydroxide (Mg-Al)/LDH nanocomposite through the co-precipitation method. The synthesized materials were characterized by XRD, FT-IR, particle size analysis, FESEM and HRTEM. Acute toxicological studies were conducted using median lethal dose LD 50 , where a total number of 98 rats (200–150 gm) of both sexes were used. An experimental wound was aseptically incised on the anterior-dorsal side of each rat, while 98% of pure medical ethanol was used for ulcer induction. Acute toxicity, wound closure rate, healing percentages, ulcer index, protective rate and histopathological studies were investigated. Antibiotic Nanocomposites has significantly prevented ulcer formation and improved wound healing process to take shorter time than that of the typical processes, when compared with that of same drugs in microscale systems or commercial standard drugs. These results were confirmed by the histopathological findings. By converting it into the Nanoform, which is extremely important, especially with commonly used antibiotics, novel pharmacological properties were acquired from the antibiotics. The safe uses of DOX/LDH and AMOX/LDH Nanocomposites in this study were approved for biomedical applications.

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Nanoparticles/thermosensitive hydrogel reinforced with chitin whiskers as a wound dressing for treating chronic wounds

Abstract: Nanoparticles/thermosensitive hydrogel reinforced with chitin whiskers as a wound dressing for treating chronic wounds.

Cited by 83 publications

References 62 publications

Chitosan-Gentamicin Conjugate Hydrogel Promoting Skin Scald Repair

Chitosan-Gentamicin Conjugate Hydrogel Promoting Skin Scald Repair

Chitosan‐Based Thermo/pH Double Sensitive Hydrogel for Controlled Drug Delivery

New Approach in Ulcer Prevention and Wound Healing Treatment using Doxycycline and Amoxicillin/LDH Nanocomposites

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