Nanoparticles in Combination With Amino Acids Change Productive and Immunological Indicators of Broiler Chicken

Abstract

A b s t r a c tThe prospects of using metal nanoparticles to stimulate productivity of farm animals are widely discussed. However, nano-sized materials exhibit various negative properties, such as prooxidant effects, and can provoke apoptosis and kidney damage. A possible approach is the use of ultrafine materials in combination with agents leveling adverse effects of nanoparticles. For the first time we studied the prospects of joint use of iron and arginine nanoparticles, the mechanism of their interaction and influence on the productivity of poultry and demonstrated that their simultaneous application promote live weight gain. We formed 6 groups (n = 30) of 11-day old broilers of the cross Smena 8. The poultry was injected twice (after 2 week intervals) with iron nanoparticles and fed either with dietary arginine (the amino acid which is known to influence metabolism and immune response and considered as conditionally essential for inflammatory and oxidative stress), or the mixture of arginine, lysine and methionine. Our experiments showed that the joint use of iron nanoparticles and arginine increased the weight gain up to 9.2 % as compared to the control, and moreover, the iron nanoparticles together with a mixture of amino acids provided an increase up to 20 %. Withal, the nanoparticles and amino acids when applied separately resulted in lower weight gain, and at the end of the experiment the body weight of broilers fed with dietary arginine (group II) and those injected with iron nanoparticles (group III) increased by 6.1 and 5.9 % (P  0.05), respectively. Intramuscular administration of iron nanoparticles (the poultry groups III, IV and VI) promoted the immune response that was manifested in enhanced level of leukocytes -by 8.12; 10.50 and 3.88 % (P  0.05), respectively, on the day 1, and by 7.3; 8.19 and 4.00 % (P  0.05), respectively, in a week. The study of NO-metabolites showed an increased level in blood and liver (by 3-4 %) only in groups III, IV and VI. Singly injected iron nanoparticles (group III) changed metabolism of arginine and increased its level by 3.83 % (P  0.05). Thus the joint use of iron nanoparticles and the complex of arginine with other amino acids is most likely to be helpful in the poultry meat production.Keywords: nanoparticles cooper, broiler chicks, growth intensity, chemical elements, biochemical and morphological parameters of bloodThe search for substances with growth-stimulating action is one of the current trends in agricultural biology. A number of studies indicate the prospects of using metal nanoparticles as preparations to increase productivity of farm animals [1,2]. Essential metal-based nanoparticles have been reported to significantly exceed the analogues in the form of mineral salts in their bioavailability [3], are characterized by less pronounced toxic effect (4), with which the promise of their use as sources of microelements is associated [5].However, nanoparticles have a number of disadvantages. They stimulate

Applications of Nanomaterials in the Meat and Seafood Processing Industry

“…Animal feeding is closely related to the meat/fish processing industry. Yausheva et al (2016) showed that the joint utilization of iron nanoparticles and arginine raised weight gain by up to 9.2% in poultry as compared to the control, and, moreover, iron nanoparticles together with a mixture of amino acids (arginine, lysine, and methionine) provided an increase of up to 20%.…”

Study of the effect of ultrafine particles of copper and iron on mineral metabolism in the body of broiler chickens on a semisynthetic diet

“…При этом большое значение придается наноматериалам как перспективным компонентам рациона животных [5]. Препараты металлических наночастиц находят все более широкое применение в качестве источников микроэлементов [6] и различных добавок [7], для повышения иммунитета животных [8], а также в качестве стимулирующих рост антибиотиков [9]. Это определяет необходимость изучения косвенного воздействия наноматериалов на гомеостаз сельскохозяйственных животных и птицы и кишечную микробиоту [10].…”

Biological effects of iodine, selenium, sulfur citrates in broiler chickens

“…The results of earlier studies indicate the pronounced biological effect of these compounds in low concentrations without manifestations of toxic reaction in the body of rats (Dolaychuk et al, 2015;Fedoruk at al., 2018) and cows, pigs, rabbits, bees (Iskra et al, 2017;Malavolta & Mocchegiani, 2018). Studies by other authors (Mohapatra et al, 2014;Yausheva et al, 2016;Landry et al, 2017) stipulate a stimulating metabolic effect of nanosized compounds of biotic mineral elements. Adequate physiological ratios of I, Se, Cr, Ge citrates, for their combined use in laboratory animals were experimentally determined (Dolaychuk et al, 2015;Iskra et al, 2017).…”

“…Feeding mature, 4-8-month-old, rats (feeding started at 4 months and lasted till the end of the 8 th month) and young, 0-4-monthold, rats (feeding started at birth and lasted for 4 months) with "nanoaquacitrates" of germanium, chromium, and selenium causes an increase of physiological reactivity in their bodies (Dolaychuk et al, 2015). The study of the biological activity of new derivatives of organic compounds I, Se, S, including those obtained on the basis of nanotechnology, indicates their high physiological activity (Yausheva et al, 2016;Iskra et al, 2017;Stoika et al, 2017). Environmental considerations and regulations limiting trace mineral supply and improvements in analytical methods to detect putative contaminants in mineral sources have led to a need for a re-examination of trace mineral requirements.…”