Nanoparticles: Antimicrobial Applications and Its Prospects

Varier, Krishnapriya M.; Gudeppu, Mounika; Chinnasamy, Arulvasu; Sumathi, Thangarajan; Balasubramanian, Jesudas; Li, Yanmei; Gajendran, Babu

doi:10.1007/978-3-030-04477-0_12

Cited by 44 publications

(26 citation statements)

References 144 publications

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“…In this context, NPs are used as antimicrobial agents either for combatting resistance against antimicrobial drugs themselves or for the delivery of conventional antimicrobials. Their efficiency is generally related to the potential of NPs to penetrate and disrupt the membrane of the microbial cells via membrane-damaging abrasiveness; to decrease the permeability of the cell; to induce antimicrobial effects within the cells, e.g., reactive oxygen species (ROS) production, nucleic acids and protein interactions, enzyme inactivation, and the overexpression of efflux pumps; to release metal ions; and to hinder the formation of biofilms ( Figure 3 ) [ 20 , 29 , 41 , 62 , 63 , 64 , 65 ]. Moreover, NPs allow for an improved drug loading and delivery of both hydrophilic and lipophilic molecules as they are able to pass the reticuloendothelial system and internalize the antimicrobials [ 20 ].…”

Section: Inorganic Nanoparticles With Antimicrobial Propertiesmentioning

confidence: 99%

Inorganic Nanoparticles and Composite Films for Antimicrobial Therapies

Spirescu

Chircov

Grumezescu

et al. 2021

IJMS

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The development of drug-resistant microorganisms has become a critical issue for modern medicine and drug discovery and development with severe socio-economic and ecological implications. Since standard and conventional treatment options are generally inefficient, leading to infection persistence and spreading, novel strategies are fundamentally necessary in order to avoid serious global health problems. In this regard, both metal and metal oxide nanoparticles (NPs) demonstrated increased effectiveness as nanobiocides due to intrinsic antimicrobial properties and as nanocarriers for antimicrobial drugs. Among them, gold, silver, copper, zinc oxide, titanium oxide, magnesium oxide, and iron oxide NPs are the most preferred, owing to their proven antimicrobial mechanisms and bio/cytocompatibility. Furthermore, inorganic NPs can be incorporated or attached to organic/inorganic films, thus broadening their application within implant or catheter coatings and wound dressings. In this context, this paper aims to provide an up-to-date overview of the most recent studies investigating inorganic NPs and their integration into composite films designed for antimicrobial therapies.

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Section: Inorganic Nanoparticles With Antimicrobial Propertiesmentioning

confidence: 99%

Inorganic Nanoparticles and Composite Films for Antimicrobial Therapies

Spirescu

Chircov

Grumezescu

et al. 2021

IJMS

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“…[252][253][254] Currently, there are no established global rules regarding the applications of food nanotechnology, however, the Organization for Economic Cooperation and Development (OECD) launched a sponsorship program for testing of nanomaterials in 2007, and the FDA issued four guidance documents on the use of nanotechnology in animal products, cosmetics, food, and other products in 2014-2015. 253 In the field of food nanotechnology, the approach of nanoparticles is considered to have the potential to be applied in various technologies, such as pesticides, 255 antimicrobial, 256 anti-solidification, 257 plant genetic engineering, 258 detection of foodborne pathogens, 259 food processing, 260 development of functional foods, 261 purification of drinking water, 262 extension of food preservation, 263 and texture improvement [252][253][254]264,265 (Figure 6). Surfactant-coated nanoparticles have been widely used in the field of food nanotechnology.…”

Section: Food Nanotechnologymentioning

confidence: 99%

A Critical Review of the Use of Surfactant-Coated Nanoparticles in Nanomedicine and Food Nanotechnology

Miyazawa¹,

Itaya²,

Burdeos³

et al. 2021

IJN

104

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Surfactants, whose existence has been recognized as early as 2800 BC, have had a long history with the development of human civilization. With the rapid development of nanotechnology in the latter half of the 20th century, breakthroughs in nanomedicine and food nanotechnology using nanoparticles have been remarkable, and new applications have been developed. The technology of surfactant-coated nanoparticles, which provides new functions to nanoparticles for use in the fields of nanomedicine and food nanotechnology, is attracting a lot of attention in the fields of basic research and industry. This review systematically describes these "surfactant-coated nanoparticles" through various sections in order: 1) surfactants, 2) surfactant-coated nanoparticles, application of surfactant-coated nanoparticles to 3) nanomedicine, and 4) food nanotechnology. Furthermore, current progress and problems of the technology using surfactant-coated nanoparticles through recent research reports have been discussed.

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“…One of the promising approaches for the smart delivery of antibacterial compounds is the use of nanocarriers ( Din et al, 2017 ). Several studies have demonstrated the advantage of antimicrobial NPs over free antimicrobial compounds ( Beyth et al, 2015 ; Wang Y. et al, 2017 ; Varier et al, 2019 ). Stability, solubility, and side effects are the important issues of pesticide use which are reduced by nanocarriers.…”

Section: Role Of Nanotechnology In Crop Protectionmentioning

confidence: 99%

Endophytic Nanotechnology: An Approach to Study Scope and Potential Applications

et al. 2021

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Nanotechnology has become a very advanced and popular form of technology with huge potentials. Nanotechnology has been very well explored in the fields of electronics, automobiles, construction, medicine, and cosmetics, but the exploration of nanotecnology’s use in agriculture is still limited. Due to climate change, each year around 40% of crops face abiotic and biotic stress; with the global demand for food increasing, nanotechnology is seen as the best method to mitigate challenges in disease management in crops by reducing the use of chemical inputs such as herbicides, pesticides, and fungicides. The use of these toxic chemicals is potentially harmful to humans and the environment. Therefore, using NPs as fungicides/ bactericides or as nanofertilizers, due to their small size and high surface area with high reactivity, reduces the problems in plant disease management. There are several methods that have been used to synthesize NPs, such as physical and chemical methods. Specially, we need ecofriendly and nontoxic methods for the synthesis of NPs. Some biological organisms like plants, algae, yeast, bacteria, actinomycetes, and fungi have emerged as superlative candidates for the biological synthesis of NPs (also considered as green synthesis). Among these biological methods, endophytic microorganisms have been widely used to synthesize NPs with low metallic ions, which opens a new possibility on the edge of biological nanotechnology. In this review, we will have discussed the different methods of synthesis of NPs, such as top-down, bottom-up, and green synthesis (specially including endophytic microorganisms) methods, their mechanisms, different forms of NPs, such as magnesium oxide nanoparticles (MgO-NPs), copper nanoparticles (Cu-NPs), chitosan nanoparticles (CS-NPs), β-d-glucan nanoparticles (GNPs), and engineered nanoparticles (quantum dots, metalloids, nonmetals, carbon nanomaterials, dendrimers, and liposomes), and their molecular approaches in various aspects. At the molecular level, nanoparticles, such as mesoporous silica nanoparticles (MSN) and RNA-interference molecules, can also be used as molecular tools to carry genetic material during genetic engineering of plants. In plant disease management, NPs can be used as biosensors to diagnose the disease.

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Nanoparticles: Antimicrobial Applications and Its Prospects

Cited by 44 publications

References 144 publications

Inorganic Nanoparticles and Composite Films for Antimicrobial Therapies

Inorganic Nanoparticles and Composite Films for Antimicrobial Therapies

A Critical Review of the Use of Surfactant-Coated Nanoparticles in Nanomedicine and Food Nanotechnology

Endophytic Nanotechnology: An Approach to Study Scope and Potential Applications

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