Nanoparticle‐Mediated Immunogenic Cell Death Enables and Potentiates Cancer Immunotherapy

Duan, Xiaopin; Chan, Cheeling; Lin, Wenbin

doi:10.1002/anie.201804882

Cited by 757 publications

(522 citation statements)

References 125 publications

Supporting

Mentioning

489

Contrasting

Unclassified

Order By: Relevance

“…[16] Unfortunately, the development of ICB therapy is compro mised with the immunosuppressive TME. [17][18][19] Recently, many researchers have proposed that the immunogenic death effect resulting from the traditional treatments, and innate immu nity elicited by immune agonists or microorganisms could efficiently improve the antitumor effect of ICB therapy. [20][21][22][23] However, the immune system damage induced by tradi tional treatments and autoimmunity evoked by agonists or microorganisms cannot be ignored.…”

mentioning

confidence: 99%

Intra/Extracellular Lactic Acid Exhaustion for Synergistic Metabolic Therapy and Immunotherapy of Tumors

et al. 2019

View full text Add to dashboard Cite

Regulating the tumor microenvironment (TME) has been a promising strategy to improve antitumor therapy. Here, a red blood cell membrane (mRBC)‐camouflaged hollow MnO2 (HMnO2) catalytic nanosystem embedded with lactate oxidase (LOX) and a glycolysis inhibitor (denoted as PMLR) is constructed for intra/extracellular lactic acid exhaustion as well as synergistic metabolic therapy and immunotherapy of tumor. Benefiting from the long‐circulation property of the mRBC, the nanosystem can gradually accumulate in a tumor site through the enhanced permeability and retention (EPR) effect. The extracellular nanosystem consumes lactic acid in the TME by catalyzing its oxidation reaction via LOX. Meanwhile, the intracellular nanosystem releases the glycolysis inhibitor to cut off the source of lactic acid, as well as achieve antitumor metabolic therapy through the blockade of the adenosine triphosphate (ATP) supply. Both the extracellular and intracellular processes can be sensitized by O2, which can be produced during the decomposition of endogenous H2O2 catalyzed by the PMLR nanosystem. The results show that the PMLR nanosystem can ceaselessly remove lactic acid, and then lead to an immunocompetent TME. Moreover, this TME regulation strategy can effectively improve the antitumor effect of anti‐PDL1 therapy without the employment of any immune agonists to avoid the autoimmunity.

show abstract

mentioning

confidence: 99%

Intra/Extracellular Lactic Acid Exhaustion for Synergistic Metabolic Therapy and Immunotherapy of Tumors

et al. 2019

View full text Add to dashboard Cite

show abstract

“…[38][39][40] To this end, we herein reported a robust approach, so called indocyanine green (ICG)templated selfassembly strategy for preparing twoinone nanomedicine and combination immuno therapy. [41][42][43][44] Tumor cells undergoing ICD expose the calreticulin (CRT) For proofofconcept, we focused on the development of ICGtemplated selfassemble of Pacli taxel (PTX) nanoparticles (termed as ISPN) for combination immunotherapy of TNBC (Figure 1b).…”

mentioning

confidence: 99%

“…ICG can perform PDT to induce immunogenic cell death (ICD) of the tumor cells. [41][42][43][44] Tumor cells undergoing ICD expose the calreticulin (CRT)…”

mentioning

confidence: 99%

Enhancing Triple Negative Breast Cancer Immunotherapy by ICG‐Templated Self‐Assembly of Paclitaxel Nanoparticles

Feng

Niu

Hou

et al. 2019

Adv Funct Materials

155

115

View full text Add to dashboard Cite

Combination cancer immunotherapy has shown promising potential for simultaneously eliciting antitumor immunity and modulating the immunosuppressive tumor microenvironment (ITM). However, combination immunotherapy with multiple regimens suffers from the varied chemophysical properties and inconsistent pharmacokinetic profiles of the different therapeutics. To achieve tumor-specific codelivery of the immune modulators, an indocyanine green (ICG)-templated self-assembly strategy for preparing dual drug-loaded two-in-one nanomedicine is reported. ICG-templated self-assembly of paclitaxel (PTX) nanoparticles (ISPN), and the application of ISPN for combination immunotherapy of the triple negative breast cancer (TNBC) are demonstrated. The ISPN show satisfied colloidal stability and high efficacy for tumor-specific codelivery of ICG and PTX through the enhanced tumor permeability and retention effect. Upon laser irradiation, the ICG component of ISPN highly efficiently induces immunogenic cell death of the tumor cells via activating antitumor immune response through photodynamic therapy. Meanwhile, PTX delivered by ISPN suppresses the regulatory T lymphocytes (T regs ) to combat ITM. The combination treatment of TNBCwith ISPN and αPD-L1-medaited immune checkpoint blockade therapy displays a synergistic effect on tumor regression, metastasis inhibition, and recurrence prevention. Overall, the ICG-templated nanomedicine may represent a robust nanoplatform for combination immunotherapy.

show abstract

“…Photodynamic therapy (PDT), which relies the cytotoxic reactive oxygen species generated from the molecular oxygen in the presence of photosensitizer and suitable light for cancer cell killing, has emerged as a promising therapeutic modality for cancer. [1][2][3][4][5][6][7] However, owing to the insufficient oxygen supply, also known as tumor hypoxia, originating from the abnormal shrinkable nano-PS by using tamoxifen (TAM), a hydrophobic antiestrogenic drug, to induce the self-assembly of chlorin e6 (Ce6)-conjugated HSA (HSA-Ce6), via the similar strategy for the preparation of Abraxane and other HSA-drug nanocomplexes. [35] Upon exposure to the slightly acidic pH similar to that in the tumor microenvironment (e.g., pH 6.5), such HSA-Ce6/TAM nanoparticles would undergo rapid structure dissociation owing to the protonation of TAM to induce its pH-responsive hydrophobic to hydrophilic transition with its pKa at 8.69.…”

Section: Introductionmentioning

confidence: 99%

Tumor‐pH‐Responsive Dissociable Albumin–Tamoxifen Nanocomplexes Enabling Efficient Tumor Penetration and Hypoxia Relief for Enhanced Cancer Photodynamic Therapy

Yang

Chen

et al. 2018

Small

104

View full text Add to dashboard Cite

Despite the promises of applying nano‐photosensitizers (nano‐PSs) for photodynamic therapy (PDT) against cancer, severe tumor hypoxia and limited tumor penetration of nano‐PSs would lead to nonoptimized therapeutic outcomes of PDT. Therefore, herein a biocompatible nano‐PS is prepared by using tamoxifen (TAM), an anti‐estrogen compound, to induce self‐assembly of chlorin e6 (Ce6) modified human serum albumin (HSA). The formed HSA–Ce6/TAM nanocomplexes, which are stable under neutral pH with a diameter of ≈130 nm, would be dissociated into individual HSA–Ce6 and TAM molecules under the acidic tumor microenvironment, owing to the pH responsive transition of TAM from hydrophobic to hydrophilic. Upon systemic administration, such HSA–Ce6/TAM nanoparticles exhibit prolonged blood circulation and high accumulation in the tumor, where it would undergo rapid pH responsive dissociation to enable obviously enhanced intratumoral penetration of HSA–Ce6. Furthermore, utilizing the ability of TAM in reducing the oxygen consumption of cancer cells, it is found that HSA–Ce6/TAM after systemic administration could efficiently attenuate the tumor hypoxia status. Those effects acting together lead to remarkably enhanced PDT treatment. This work presents a rather simple approach to fabricate smart nano‐PSs with multiple functions integrated into a single system via self‐assembly of all‐biocompatible components, promising for the next generation cancer PDT.

show abstract

Nanoparticle‐Mediated Immunogenic Cell Death Enables and Potentiates Cancer Immunotherapy

Cited by 757 publications

References 125 publications

Intra/Extracellular Lactic Acid Exhaustion for Synergistic Metabolic Therapy and Immunotherapy of Tumors

Intra/Extracellular Lactic Acid Exhaustion for Synergistic Metabolic Therapy and Immunotherapy of Tumors

Enhancing Triple Negative Breast Cancer Immunotherapy by ICG‐Templated Self‐Assembly of Paclitaxel Nanoparticles

Tumor‐pH‐Responsive Dissociable Albumin–Tamoxifen Nanocomplexes Enabling Efficient Tumor Penetration and Hypoxia Relief for Enhanced Cancer Photodynamic Therapy

Contact Info

Product

Resources

About