2008
DOI: 10.1073/pnas.0807296105
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: The nonspecific adsorption of charged nanoparticles onto singlecomponent phospholipid bilayers bearing phosphocholine headgroups is shown, from fluorescence and calorimetry experiments, to cause surface reconstruction at the points where nanoparticles adsorb. Nanoparticles of negative charge induce local gelation in otherwise fluid bilayers; nanoparticles of positive charge induce otherwise gelled membranes to fluidize locally. Through this mechanism, the phase state deviates from the nominal phase transition … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

20
441
7
2

Year Published

2010
2010
2021
2021

Publication Types

Select...
6
2

Relationship

0
8

Authors

Journals

citations
Cited by 437 publications
(470 citation statements)
references
References 27 publications
20
441
7
2
Order By: Relevance
“…22 Superparamagnetic iron oxide (SPIO) and gold (Au) nanoparticles have been reported in the field of tumor disgnostics and cancer treatment. [9][10][16][17][18][19][20][21] Semiconducting nanocrystals, e.g. quantum dots, were used to improve biological imaging for medical diagnostics, 14 and these crystals were able to offer resolutions up to 1,000 times better than conventional dyes used in many biological tests.…”
Section: Nanoparticle -Membrane Interactionmentioning
confidence: 99%
“…22 Superparamagnetic iron oxide (SPIO) and gold (Au) nanoparticles have been reported in the field of tumor disgnostics and cancer treatment. [9][10][16][17][18][19][20][21] Semiconducting nanocrystals, e.g. quantum dots, were used to improve biological imaging for medical diagnostics, 14 and these crystals were able to offer resolutions up to 1,000 times better than conventional dyes used in many biological tests.…”
Section: Nanoparticle -Membrane Interactionmentioning
confidence: 99%
“…The interaction between cell membranes and nanocarriers, such as dendrimers, is very important, because in the most cases carriers have to get across the lipid bilayer without disrupting it. Previous studies based on atomic force microscopy (AFM) [12][13][14][15][16][17] isothermal titration calorimetry (ITC), fluorescence correlated spectroscopy (FCS) [17][18], in vitro experiments [13,[19][20] and molecular dynamics simulations (MD) [14,17,[21][22][23][24] showed that cationic dendrimers disrupt lipid bilayers by forming holes on the bilayer surface and may remove lipids from it. The degree of the disruption depends on the size and charge of the dendrimer.…”
Section: Introductionmentioning
confidence: 99%
“…In fluid-phase membrane, P − N + dipole is nearly parallel to the local bilayer plane with an average angel of 0-3 • [33]. Anionic NPs interact preferentially with N + terminus and raise the tilt angle of P − N + dipole, increase lipid density and induce membrane gelation [15]. Such explanation focuses the effect of electrostatic forces and in our study fits the performance of anionic silicon NPs (AS/LS/DP1/DS1) very well.…”
Section: Influence On Membrane Fluidity Studied By Fluorescence Spectramentioning
confidence: 99%
“…Cell membrane is a phospholipid bilayer with the main roles of separating intracellular and extracellular environments, and providing an anisotropic fluid phase to support proteins and to regulate molecular transport. The membrane integrity and fluidity are essential and important to cell physiological activities, which may be affected by NP attachments [12,15]. NP-induced plasma membrane disruption has been suggested for a wide range of NPs through lactate dehydrogenase (LDH) assay [16].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation