Nanomaterials-induced toxicity on cardiac myocytes and tissues, and emerging toxicity assessment techniques

Yan-ping, Cheng; Chen, Zaozao; Yang, Sheng; Liu, Tong; Yin, Lihong; Pu, Yuepu; Liang, Geyu

doi:10.1016/j.scitotenv.2021.149584

Cited by 24 publications

(12 citation statements)

References 112 publications

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“…242 More and more studies have found that NPs can affect mitochondrial function or cause mitochondrial damage to cause apoptosis. 243 Recent studies have shown that nanocomposites disrupt the Ca+ buffering function of mitochondria in tumor-associated macrophages, triggering calcium overload and causing mitochondrial damage. Huang et al 244 showed that decabromodiphenylethane and ZnO-NPs reduced mitochondrial membrane potential (MMP), increased cytochrome C release, and modulated Bax/Bcl-2 and cysteine by disrupting mitochondrial kinetic homeostasis Apoptosis was induced by the expression of dp-3 mRNA and protein.…”

Section: Studies Between Nps and Mitochondrial Damagementioning

confidence: 99%

“…These include mitochondrial proteases, proteasome‐mediated outer mitochondrial membrane protein degradation, mitochondrial‐derived vesicle degradation, and mitophagy 242 . More and more studies have found that NPs can affect mitochondrial function or cause mitochondrial damage to cause apoptosis 243 . Recent studies have shown that nanocomposites disrupt the Ca+ buffering function of mitochondria in tumor‐associated macrophages, triggering calcium overload and causing mitochondrial damage.…”

Section: Toxicological Mechanisms Of Npsmentioning

confidence: 99%

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Nanoparticles‐induced potential toxicity on human health: Applications, toxicity mechanisms, and evaluation models

Xuan

Zhao

Skonieczna

et al. 2023

MedComm

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Nanoparticles (NPs) have become one of the most popular objects of scientific study during the past decades. However, despite wealth of study reports, still there is a gap, particularly in health toxicology studies, underlying mechanisms, and related evaluation models to deeply understanding the NPs risk effects. In this review, we first present a comprehensive landscape of the applications of NPs on health, especially addressing the role of NPs in medical diagnosis, therapy. Then, the toxicity of NPs on health systems is introduced. We describe in detail the effects of NPs on various systems, including respiratory, nervous, endocrine, immune, and reproductive systems, and the carcinogenicity of NPs. Furthermore, we unravels the underlying mechanisms of NPs including ROS accumulation, mitochondrial damage, inflammatory reaction, apoptosis, DNA damage, cell cycle, and epigenetic regulation. In addition, the classical study models such as cell lines and mice and the emerging models such as 3D organoids used for evaluating the toxicity or scientific study are both introduced. Overall, this review presents a critical summary and evaluation of the state of understanding of NPs, giving readers more better understanding of the NPs toxicology to remedy key gaps in knowledge and techniques.

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Section: Studies Between Nps and Mitochondrial Damagementioning

confidence: 99%

Section: Toxicological Mechanisms Of Npsmentioning

confidence: 99%

Nanoparticles‐induced potential toxicity on human health: Applications, toxicity mechanisms, and evaluation models

Xuan

Zhao

Skonieczna

et al. 2023

MedComm

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“…Current research in the field suggests that long-term exposure to a relatively high dose of NPs impairs cardiovascular electrophysiology and damages mitochondria and cardiomyocytes via oxidative stress, apoptosis, and inflammatory responses. 70 Despite the remarkable influence of CNTs on the electrical activity and mechanical properties of composite CPs, clinical advancement of the systems is impeded by the possibility of atherosclerotic plaque, vasomotor dysfunction, and a change in blood pressure or heart rate. However, these problems can be mitigated by controlling certain factors such as the lengths, diameters, and surface chemistry of the tubes.…”

Section: Safety Aspects Of Nanoparticlesmentioning

confidence: 99%

“…Nonetheless, some reports indicate that the electrical charge of the particles is also a crucial factor. Current research in the field suggests that long‐term exposure to a relatively high dose of NPs impairs cardiovascular electrophysiology and damages mitochondria and cardiomyocytes via oxidative stress, apoptosis, and inflammatory responses 70 . Despite the remarkable influence of CNTs on the electrical activity and mechanical properties of composite CPs, clinical advancement of the systems is impeded by the possibility of atherosclerotic plaque, vasomotor dysfunction, and a change in blood pressure or heart rate.…”

Section: Safety Aspects Of Nanoparticlesmentioning

confidence: 99%

Conductive polymers for cardiac tissue engineering and regeneration

et al. 2023

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Cardiovascular diseases, such as myocardial infarction, are considered a significant global burden and the leading cause of death. Given the inability of damaged cardiac tissue to self‐repair, cell‐based tissue engineering and regeneration may be the only viable option for restoring normal heart function. To maintain the normal excitation‐contraction coupling function of cardiac tissue, uniform electronic and ionic conductance properties are required. To transport cells to damaged cardiac tissues, several techniques, including the incorporation of cells into conductive polymers (CPs) and biomaterials, have been utilized. Due to the complexity of cardiac tissues, the success of tissue engineering for the damaged heart is highly dependent on several variables, such as the cell source, growth factors, and scaffolds. In this review, we sought to provide a comprehensive overview of the electro CPs and biomaterials used in the engineering and regeneration of heart tissue.

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“…Due to their small size and high permeability, CNTs can penetrate biological barriers and enter the blood. They can also enter the body’s circulation directly by injection into a vein or by surgery, thus reaching the heart [ 101 ]. Studies reported that ultrafine particles can translocate from the lungs to the systemic circulation by crossing the alveolar–capillary barrier [ 102 ].…”

Section: Cardiovascular Toxicitymentioning

confidence: 99%

Assessment of Pristine Carbon Nanotubes Toxicity in Rodent Models

Witkowska

Florek

Mrówczyński

2022

IJMS

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Carbon nanotubes are increasingly used in nanomedicine and material chemistry research, mostly because of their small size over a large surface area. Due to their properties, they are very attractive candidates for use in medicine and as drug carriers, contrast agents, biological platforms, and so forth. Carbon nanotubes (CNTs) may affect many organs, directly or indirectly, so there is a need for toxic effects evaluation. The main mechanisms of toxicity include oxidative stress, inflammation, the ability to damage DNA and cell membrane, as well as necrosis and apoptosis. The research concerning CNTs focuses on different animal models, functionalization, ways of administration, concentrations, times of exposure, and a variety of properties, which have a significant effect on toxicity. The impact of pristine CNTs on toxicity in rodent models is being increasingly studied. However, it is immensely difficult to compare obtained results since there are no standardized tests. This review summarizes the toxicity issues of pristine CNTs in rodent models, as they are often the preferred model for human disease studies, in different organ systems, while considering the various factors that affect them. Regardless, the results showed that the majority of toxicological studies using rodent models revealed some toxic effects. Even with different properties, carbon nanotubes were able to generate inflammation, fibrosis, or biochemical changes in different organs. The problem is that there are only a small amount of long-term toxicity studies, which makes it impossible to obtain a good understanding of later effects. This article will give a greater overview of the situation on toxicity in many organs. It will allow researchers to look at the toxicity of carbon nanotubes in a broader context and help to identify studies that are missing to properly assess toxicity.

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Nanomaterials-induced toxicity on cardiac myocytes and tissues, and emerging toxicity assessment techniques

Cited by 24 publications

References 112 publications

Nanoparticles‐induced potential toxicity on human health: Applications, toxicity mechanisms, and evaluation models

Nanoparticles‐induced potential toxicity on human health: Applications, toxicity mechanisms, and evaluation models

Conductive polymers for cardiac tissue engineering and regeneration

Assessment of Pristine Carbon Nanotubes Toxicity in Rodent Models

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